DDI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDI1_HUMAN
• UniProt AC: Q8WTU0
• Protein Name: Protein DDI1 homolog 1
• Gene Name: DDI1
• Organism: Homo sapiens (Human).
• Sequence Length: 396
• Protein Description: Probable aspartic protease..
• Protein Sequence: MLITVYCVRRDLSEVTFSLQVSPDFELRNFKVLCEAESRVPVEEIQIIHMERLLIEDHCSLGSYGLKDGDIVVLLQKDNVGPRAPGRAPNQPRVDFSGIAVPGTSSSRPQHPGQQQQRTPAAQRSQGLASGEKVAGLQGLGSPALIRSMLLSNPHDLSLLKERNPPLAEALLSGSLETFSQVLMEQQREKALREQERLRLYTADPLDREAQAKIEEEIRQQNIEENMNIAIEEAPESFGQVTMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIIGRVHLAQIQIEGDFLQCSFSILEDQPMDMLLGLDMLRRHQCSIDLKKNVLVIGTTGTQTYFLPEGELPLCSRMVSGQDESSDKEITHSVMDSGRKEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	YCVRRDLSEVTFSLQ EEEECCHHCCEEEEE	34.02	29978859
16	Phosphorylation	RRDLSEVTFSLQVSP ECCHHCCEEEEEECC	11.94	29978859
18	Phosphorylation	DLSEVTFSLQVSPDF CHHCCEEEEEECCCC	14.45	29978859
22	Phosphorylation	VTFSLQVSPDFELRN CEEEEEECCCCEECC	13.04	29978859
107	Phosphorylation	AVPGTSSSRPQHPGQ ECCCCCCCCCCCCCC	47.98	-
142	Phosphorylation	AGLQGLGSPALIRSM CCCCCCCCHHHHHHH	16.43	25693802
158	Phosphorylation	LSNPHDLSLLKERNP HCCHHHHHHHHHHCC	37.40	24719451
173	Phosphorylation	PLAEALLSGSLETFS HHHHHHHHCCHHHHH	27.47	25693802
175	Phosphorylation	AEALLSGSLETFSQV HHHHHHCCHHHHHHH	21.47	25693802
178	Phosphorylation	LLSGSLETFSQVLME HHHCCHHHHHHHHHH	33.60	25693802
180	Phosphorylation	SGSLETFSQVLMEQQ HCCHHHHHHHHHHHH	27.14	25693802
201	Phosphorylation	EQERLRLYTADPLDR HHHHHHHHCCCCCCH	8.08	-
202	Phosphorylation	QERLRLYTADPLDRE HHHHHHHCCCCCCHH	29.22	-
341	Phosphorylation	MLRRHQCSIDLKKNV HHHHHCCCCCCCCCE	16.74	24961811
345	Ubiquitination	HQCSIDLKKNVLVIG HCCCCCCCCCEEEEE	38.26	29901268
346	Ubiquitination	QCSIDLKKNVLVIGT CCCCCCCCCEEEEEC	60.63	-
379	Phosphorylation	MVSGQDESSDKEITH ECCCCCCCCCHHHCH	52.72	-
380	Phosphorylation	VSGQDESSDKEITHS CCCCCCCCCHHHCHH	51.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	UBE3A	Q05086	PMID:31130875

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	16007098
UBP47_HUMAN	USP47	physical	26186194
NRIP3_HUMAN	NRIP3	physical	26186194
RSCA1_HUMAN	RSC1A1	physical	26186194
PHC3_HUMAN	PHC3	physical	26186194
CCL28_HUMAN	CCL28	physical	21516116
NRIP3_HUMAN	NRIP3	physical	28514442
UBP47_HUMAN	USP47	physical	28514442
PHC3_HUMAN	PHC3	physical	28514442
RSCA1_HUMAN	RSC1A1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.