dbPTM

PHC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHC3_HUMAN
UniProt AC	Q8NDX5
Protein Name	Polyhomeotic-like protein 3
Gene Name	PHC3
Organism	Homo sapiens (Human).
Sequence Length	983
Subcellular Localization	Nucleus .
Protein Description	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility..
Protein Sequence	MDTEPNPGTSSVSTTTSSTTTTTITTSSSRMQQPQISVYSGSDRHAVQVIQQALHRPPSSAAQYLQQMYAAQQQHLMLHTAALQQQHLSSSQLQSLAAVQASLSSGRPSTSPTGSVTQQSSMSQTSINLSTSPTPAQLISRSQASSSTSGSITQQTMLLGSTSPTLTASQAQMYLRAQMLIFTPATTVAAVQSDIPVVSSSSSSSCQSAATQVQNLTLRSQKLGVLSSSQNGPPKSTSQTQSLTICHNKTTVTSSKISQRDPSPESNKKGESPSLESRSTAVTRTSSIHQLIAPASYSPIQPHSLIKHQQIPLHSPPSKVSHHQLILQQQQQQIQPITLQNSTQDPPPSQHCIPLQNHGLPPAPSNAQSQHCSPIQSHPSPLTVSPNQSQSAQQSVVVSPPPPHSPSQSPTIIIHPQALIQPHPLVSSALQPGPNLQQSTANQVQATAQLNLPSHLPLPASPVVHIGPVQQSALVSPGQQIVSPSHQQYSSLQSSPIPIASPPQMSTSPPAQIPPLPLQSMQSLQVQPEILSQGQVLVQNALVSEEELPAAEALVQLPFQTLPPPQTVAVNLQVQPPAPVDPPVVYQVEDVCEEEMPEESDECVRMDRTPPPPTLSPAAITVGRGEDLTSEHPLLEQVELPAVASVSASVIKSPSDPSHVSVPPPPLLLPAATTRSNSTSMHSSIPSIENKPPQAIVKPQILTHVIEGFVIQEGLEPFPVSRSSLLIEQPVKKRPLLDNQVINSVCVQPELQNNTKHADNSSDTEMEDMIAEETLEEMDSELLKCEFCGKMGYANEFLRSKRFCTMSCAKRYNVSCSKKFALSRWNRKPDNQSLGHRGRRPSGPDGAAREHILRQLPITYPSAEEDLASHEDSVPSAMTTRLRRQSERERERELRDVRIRKMPENSDLLPVAQTEPSIWTVDDVWAFIHSLPGCQDIADEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICARINSLKES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	O-linked_Glycosylation	RMQQPQISVYSGSDR CCCCCEEEEECCCCH	15.12	20068230
37	Phosphorylation	RMQQPQISVYSGSDR CCCCCEEEEECCCCH	15.12	20068231
39	Phosphorylation	QQPQISVYSGSDRHA CCCEEEEECCCCHHH	10.67	20068231
40	Phosphorylation	QPQISVYSGSDRHAV CCEEEEECCCCHHHH	29.66	20068231
42	Phosphorylation	QISVYSGSDRHAVQV EEEEECCCCHHHHHH	26.07	20068231
59	O-linked_Glycosylation	QALHRPPSSAAQYLQ HHHCCCCCHHHHHHH	34.98	20068230
60	O-linked_Glycosylation	ALHRPPSSAAQYLQQ HHCCCCCHHHHHHHH	33.14	20068230
113	Phosphorylation	GRPSTSPTGSVTQQS CCCCCCCCCCCCCCC	41.68	30576142
113 (in isoform 2)	Phosphorylation	-	41.68	22210691
117	Phosphorylation	TSPTGSVTQQSSMSQ CCCCCCCCCCCCCCC	23.69	30576142
120	Phosphorylation	TGSVTQQSSMSQTSI CCCCCCCCCCCCEEE	20.42	30576142
125	Phosphorylation	QQSSMSQTSINLSTS CCCCCCCEEEECCCC	25.03	30576142
131	Phosphorylation	QTSINLSTSPTPAQL CEEEECCCCCCHHHH	41.72	30576142
146 (in isoform 2)	Phosphorylation	-	40.42	22210691
147	Phosphorylation	SRSQASSSTSGSITQ HHHHCCCCCCCCEEH	24.89	22210691
155 (in isoform 2)	Phosphorylation	-	21.89	22210691
161	Phosphorylation	QQTMLLGSTSPTLTA HHEEECCCCCCCCCH	26.19	26074081
162	Phosphorylation	QTMLLGSTSPTLTAS HEEECCCCCCCCCHH	36.61	26074081
163	Phosphorylation	TMLLGSTSPTLTASQ EEECCCCCCCCCHHH	19.99	26074081
165	Phosphorylation	LLGSTSPTLTASQAQ ECCCCCCCCCHHHHH	36.19	26074081
167	Phosphorylation	GSTSPTLTASQAQMY CCCCCCCCHHHHHHH	27.09	26074081
169	Phosphorylation	TSPTLTASQAQMYLR CCCCCCHHHHHHHHH	22.33	22210691
175	Phosphorylation	ASQAQMYLRAQMLIF HHHHHHHHHHCEECC	2.84	27251275
217	Phosphorylation	ATQVQNLTLRSQKLG HHHHHHHHHHHHHHC	27.89	24719451
222	Sumoylation	NLTLRSQKLGVLSSS HHHHHHHHHCCCCCC	48.75	-
222	Acetylation	NLTLRSQKLGVLSSS HHHHHHHHHCCCCCC	48.75	25953088
222	Sumoylation	NLTLRSQKLGVLSSS HHHHHHHHHCCCCCC	48.75	-
222	Ubiquitination	NLTLRSQKLGVLSSS HHHHHHHHHCCCCCC	48.75	-
227	Phosphorylation	SQKLGVLSSSQNGPP HHHHCCCCCCCCCCC	26.07	23186163
228	Phosphorylation	QKLGVLSSSQNGPPK HHHCCCCCCCCCCCC	31.61	25159151
229	Phosphorylation	KLGVLSSSQNGPPKS HHCCCCCCCCCCCCC	25.04	17525332
234 (in isoform 7)	Ubiquitination	-	44.63	-
235	Ubiquitination	SSQNGPPKSTSQTQS CCCCCCCCCCCCCEE	70.29	-
236	O-linked_Glycosylation	SQNGPPKSTSQTQSL CCCCCCCCCCCCEEE	38.78	20068230
236	Phosphorylation	SQNGPPKSTSQTQSL CCCCCCCCCCCCEEE	38.78	29083192
237	O-linked_Glycosylation	QNGPPKSTSQTQSLT CCCCCCCCCCCEEEE	30.86	20068230
237	Phosphorylation	QNGPPKSTSQTQSLT CCCCCCCCCCCEEEE	30.86	29083192
238	O-linked_Glycosylation	NGPPKSTSQTQSLTI CCCCCCCCCCEEEEE	38.02	20068230
238	Phosphorylation	NGPPKSTSQTQSLTI CCCCCCCCCCEEEEE	38.02	29083192
240	O-linked_Glycosylation	PPKSTSQTQSLTICH CCCCCCCCEEEEEEE	21.64	20068230
240	Phosphorylation	PPKSTSQTQSLTICH CCCCCCCCEEEEEEE	21.64	29083192
242	O-linked_Glycosylation	KSTSQTQSLTICHNK CCCCCCEEEEEEECC	30.76	20068230
242	Phosphorylation	KSTSQTQSLTICHNK CCCCCCEEEEEEECC	30.76	29083192
244	O-linked_Glycosylation	TSQTQSLTICHNKTT CCCCEEEEEEECCCE	27.14	20068230
244	Phosphorylation	TSQTQSLTICHNKTT CCCCEEEEEEECCCE	27.14	29083192
250	O-linked_Glycosylation	LTICHNKTTVTSSKI EEEEECCCEECCCCC	31.64	20068230
250	Phosphorylation	LTICHNKTTVTSSKI EEEEECCCEECCCCC	31.64	28060719
251	Phosphorylation	TICHNKTTVTSSKIS EEEECCCEECCCCCC	24.32	28060719
253	O-linked_Glycosylation	CHNKTTVTSSKISQR EECCCEECCCCCCCC	25.78	20068230
253	Phosphorylation	CHNKTTVTSSKISQR EECCCEECCCCCCCC	25.78	28060719
254	O-linked_Glycosylation	HNKTTVTSSKISQRD ECCCEECCCCCCCCC	25.87	20068230
254	Phosphorylation	HNKTTVTSSKISQRD ECCCEECCCCCCCCC	25.87	28060719
255	Phosphorylation	NKTTVTSSKISQRDP CCCEECCCCCCCCCC	25.33	28060719
256	Acetylation	KTTVTSSKISQRDPS CCEECCCCCCCCCCC	46.25	25953088
256	Ubiquitination	KTTVTSSKISQRDPS CCEECCCCCCCCCCC	46.25	-
258	Phosphorylation	TVTSSKISQRDPSPE EECCCCCCCCCCCCC	23.93	28176443
263	Phosphorylation	KISQRDPSPESNKKG CCCCCCCCCCCCCCC	45.66	25159151
266	Phosphorylation	QRDPSPESNKKGESP CCCCCCCCCCCCCCC	58.28	28176443
269	Ubiquitination	PSPESNKKGESPSLE CCCCCCCCCCCCCHH	72.64	-
272	Phosphorylation	ESNKKGESPSLESRS CCCCCCCCCCHHHHC	28.58	23401153
274	Phosphorylation	NKKGESPSLESRSTA CCCCCCCCHHHHCCC	54.79	30108239
275	Phosphorylation	KKGESPSLESRSTAV CCCCCCCHHHHCCCC	8.65	24719451
277	Phosphorylation	GESPSLESRSTAVTR CCCCCHHHHCCCCCC	36.50	24702127
279	O-linked_Glycosylation	SPSLESRSTAVTRTS CCCHHHHCCCCCCCC	29.96	20068230
281 (in isoform 7)	Ubiquitination	-	11.26	-
283	O-linked_Glycosylation	ESRSTAVTRTSSIHQ HHHCCCCCCCCCCHH	26.26	20068230
283	O-linked_Glycosylation	ESRSTAVTRTSSIHQ HHHCCCCCCCCCCHH	26.26	20068230
284	Phosphorylation	SRSTAVTRTSSIHQL HHCCCCCCCCCCHHH	26.47	24719451
285	Phosphorylation	RSTAVTRTSSIHQLI HCCCCCCCCCCHHHH	19.91	25159151
286	Phosphorylation	STAVTRTSSIHQLIA CCCCCCCCCCHHHHC	24.81	25159151
287	Phosphorylation	TAVTRTSSIHQLIAP CCCCCCCCCHHHHCC	24.39	25159151
296	Phosphorylation	HQLIAPASYSPIQPH HHHHCCCCCCCCCCC	25.69	25159151
297	Phosphorylation	QLIAPASYSPIQPHS HHHCCCCCCCCCCCC	22.14	24732914
298	Phosphorylation	LIAPASYSPIQPHSL HHCCCCCCCCCCCCC	17.03	25159151
299	Phosphorylation	IAPASYSPIQPHSLI HCCCCCCCCCCCCCC	22.47	27251275
304	Phosphorylation	YSPIQPHSLIKHQQI CCCCCCCCCCCCCCC	38.17	24732914
308	Phosphorylation	QPHSLIKHQQIPLHS CCCCCCCCCCCCCCC	20.13	24719451
310	Phosphorylation	HSLIKHQQIPLHSPP CCCCCCCCCCCCCCC	38.70	27251275
315	Phosphorylation	HQQIPLHSPPSKVSH CCCCCCCCCCCCCCH	46.30	25159151
318	Phosphorylation	IPLHSPPSKVSHHQL CCCCCCCCCCCHHHH	49.42	30266825
327	Phosphorylation	VSHHQLILQQQQQQI CCHHHHHHHHHHHHC	5.24	24719451
383	Phosphorylation	QSHPSPLTVSPNQSQ CCCCCCCCCCCCCCC	23.48	26074081
385	Phosphorylation	HPSPLTVSPNQSQSA CCCCCCCCCCCCCCC	16.94	26074081
389	Phosphorylation	LTVSPNQSQSAQQSV CCCCCCCCCCCCCCE	32.51	26074081
391	Phosphorylation	VSPNQSQSAQQSVVV CCCCCCCCCCCCEEE	33.04	26074081
395	Phosphorylation	QSQSAQQSVVVSPPP CCCCCCCCEEECCCC	12.56	26074081
399	Phosphorylation	AQQSVVVSPPPPHSP CCCCEEECCCCCCCC	21.78	26074081
405	Phosphorylation	VSPPPPHSPSQSPTI ECCCCCCCCCCCCEE	31.83	26074081
407	Phosphorylation	PPPPHSPSQSPTIII CCCCCCCCCCCEEEE	46.43	26074081
409	Phosphorylation	PPHSPSQSPTIIIHP CCCCCCCCCEEEECC	28.48	26074081
411	Phosphorylation	HSPSQSPTIIIHPQA CCCCCCCEEEECCCC	30.01	26074081
609	Phosphorylation	ECVRMDRTPPPPTLS CCCCCCCCCCCCCCC	35.56	22322096
614	Phosphorylation	DRTPPPPTLSPAAIT CCCCCCCCCCCCEEE	45.71	22322096
616	Phosphorylation	TPPPPTLSPAAITVG CCCCCCCCCCEEEEC	18.25	22322096
621	Phosphorylation	TLSPAAITVGRGEDL CCCCCEEEECCCCCC	16.51	30266825
626	Phosphorylation	AITVGRGEDLTSEHP EEEECCCCCCCCCCC	48.78	24719451
628	Phosphorylation	TVGRGEDLTSEHPLL EECCCCCCCCCCCCH	5.03	27251275
629	Phosphorylation	VGRGEDLTSEHPLLE ECCCCCCCCCCCCHH	44.37	26074081
630	Phosphorylation	GRGEDLTSEHPLLEQ CCCCCCCCCCCCHHC	41.00	26074081
645	Phosphorylation	VELPAVASVSASVIK CCCCCEEEEEEECCC	15.25	20068231
647	Phosphorylation	LPAVASVSASVIKSP CCCEEEEEEECCCCC	16.60	20068231
649	Phosphorylation	AVASVSASVIKSPSD CEEEEEEECCCCCCC	19.50	20068231
653	Phosphorylation	VSASVIKSPSDPSHV EEEECCCCCCCCCCC	20.64	25159151
655	Phosphorylation	ASVIKSPSDPSHVSV EECCCCCCCCCCCCC	70.06	25159151
658	Phosphorylation	IKSPSDPSHVSVPPP CCCCCCCCCCCCCCC	41.32	25159151
661	Phosphorylation	PSDPSHVSVPPPPLL CCCCCCCCCCCCCCC	24.39	25159151
665	Phosphorylation	SHVSVPPPPLLLPAA CCCCCCCCCCCCCCC	26.54	27251275
673	O-linked_Glycosylation	PLLLPAATTRSNSTS CCCCCCCCCCCCCCC	25.50	20068230
674	O-linked_Glycosylation	LLLPAATTRSNSTSM CCCCCCCCCCCCCCC	27.63	20068230
676	Phosphorylation	LPAATTRSNSTSMHS CCCCCCCCCCCCCCC	32.80	23090842
678	Phosphorylation	AATTRSNSTSMHSSI CCCCCCCCCCCCCCC	24.09	25849741
679	Phosphorylation	ATTRSNSTSMHSSIP CCCCCCCCCCCCCCC	34.03	23090842
680	Phosphorylation	TTRSNSTSMHSSIPS CCCCCCCCCCCCCCC	17.83	23090842
683	Phosphorylation	SNSTSMHSSIPSIEN CCCCCCCCCCCCCCC	22.71	23090842
684	Phosphorylation	NSTSMHSSIPSIENK CCCCCCCCCCCCCCC	24.68	23090842
687	Phosphorylation	SMHSSIPSIENKPPQ CCCCCCCCCCCCCCC	40.64	23090842
691	Phosphorylation	SIPSIENKPPQAIVK CCCCCCCCCCCCCCC	45.33	27251275
691	Sumoylation	SIPSIENKPPQAIVK CCCCCCCCCCCCCCC	45.33	28112733
721	O-linked_Glycosylation	GLEPFPVSRSSLLIE CCCCCCCCHHHEEEE	27.04	20068230
723	Phosphorylation	EPFPVSRSSLLIEQP CCCCCCHHHEEEECC	20.17	19691289
724	Phosphorylation	PFPVSRSSLLIEQPV CCCCCHHHEEEECCC	26.53	25159151
732	Acetylation	LLIEQPVKKRPLLDN EEEECCCCCCCCCCC	50.15	25953088
732	Sumoylation	LLIEQPVKKRPLLDN EEEECCCCCCCCCCC	50.15	28112733
732	Ubiquitination	LLIEQPVKKRPLLDN EEEECCCCCCCCCCC	50.15	-
733	Ubiquitination	LIEQPVKKRPLLDNQ EEECCCCCCCCCCCH	60.53	-
736	Phosphorylation	QPVKKRPLLDNQVIN CCCCCCCCCCCHHEE	12.46	27251275
744	O-linked_Glycosylation	LDNQVINSVCVQPEL CCCHHEEEEECCHHH	13.03	20068230
761	Phosphorylation	NTKHADNSSDTEMED CCCCCCCCCCHHHHH	30.09	30278072
762	Phosphorylation	TKHADNSSDTEMEDM CCCCCCCCCHHHHHH	55.60	30278072
764	Phosphorylation	HADNSSDTEMEDMIA CCCCCCCHHHHHHHH	38.90	30278072
773	Phosphorylation	MEDMIAEETLEEMDS HHHHHHHHHHHHHCH	50.07	27251275
774	Phosphorylation	EDMIAEETLEEMDSE HHHHHHHHHHHHCHH	30.86	23403867
776	Phosphorylation	MIAEETLEEMDSELL HHHHHHHHHHCHHHH	59.71	27251275
780	Phosphorylation	ETLEEMDSELLKCEF HHHHHHCHHHHHCCC	28.91	23403867
807	Phosphorylation	SKRFCTMSCAKRYNV CCCCCCHHHHHHHCC	7.86	25627689
810	Sumoylation	FCTMSCAKRYNVSCS CCCHHHHHHHCCCCC	60.79	28112733
815	Phosphorylation	CAKRYNVSCSKKFAL HHHHHCCCCCCCCHH	14.72	-
817	Phosphorylation	KRYNVSCSKKFALSR HHHCCCCCCCCHHHH	31.23	-
828	Acetylation	ALSRWNRKPDNQSLG HHHHCCCCCCCCCCC	54.21	155409
837	Methylation	DNQSLGHRGRRPSGP CCCCCCCCCCCCCCC	38.22	26493849
839	Methylation	QSLGHRGRRPSGPDG CCCCCCCCCCCCCCH	47.49	115487371
842	Phosphorylation	GHRGRRPSGPDGAAR CCCCCCCCCCCHHHH	62.23	27273156
854	Phosphorylation	AAREHILRQLPITYP HHHHHHHHHCCCCCC	35.07	24719451
859	Phosphorylation	ILRQLPITYPSAEED HHHHCCCCCCCHHHH	27.69	28450419
860	Phosphorylation	LRQLPITYPSAEEDL HHHCCCCCCCHHHHH	8.91	26074081
862	Phosphorylation	QLPITYPSAEEDLAS HCCCCCCCHHHHHHC	37.59	28450419
869	Phosphorylation	SAEEDLASHEDSVPS CHHHHHHCCCCCCCH	34.41	28450419
873	Phosphorylation	DLASHEDSVPSAMTT HHHCCCCCCCHHHHH	32.70	26074081
874	Phosphorylation	LASHEDSVPSAMTTR HHCCCCCCCHHHHHH	7.21	24719451
876	Phosphorylation	SHEDSVPSAMTTRLR CCCCCCCHHHHHHHH	28.63	26074081
879	Phosphorylation	DSVPSAMTTRLRRQS CCCCHHHHHHHHHHH	14.42	26074081
880	Phosphorylation	SVPSAMTTRLRRQSE CCCHHHHHHHHHHHH	18.02	26074081
881	Phosphorylation	VPSAMTTRLRRQSER CCHHHHHHHHHHHHH	19.61	27251275
886	Phosphorylation	TTRLRRQSERERERE HHHHHHHHHHHHHHH	36.49	-
906	Phosphorylation	IRKMPENSDLLPVAQ HHCCCCCCCCCCCCC	28.15	28787133
914	Phosphorylation	DLLPVAQTEPSIWTV CCCCCCCCCCCCEEH	39.88	28787133
917	Phosphorylation	PVAQTEPSIWTVDDV CCCCCCCCCEEHHHH	25.24	28787133
920	Phosphorylation	QTEPSIWTVDDVWAF CCCCCCEEHHHHHHH	16.64	28787133
966	Sumoylation	LMSAMNIKLGPALKI HHHHHCCCHHHHHHH	42.24	-
966	Sumoylation	LMSAMNIKLGPALKI HHHHHCCCHHHHHHH	42.24	-
979	Phosphorylation	KICARINSLKES--- HHHHHHHHHCCC---	38.15	24719451
983	Phosphorylation	RINSLKES------- HHHHHCCC-------	0.00	27251275
991	Phosphorylation	--------------- ---------------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PHC3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RING2_HUMAN	RNF2	physical	22325352
PCGF2_HUMAN	PCGF2	physical	22325352
BMI1_HUMAN	BMI1	physical	22325352
RING1_HUMAN	RING1	physical	22325352
PHC1_HUMAN	PHC1	physical	22325352
PHC2_HUMAN	PHC2	physical	22325352
CBX2_HUMAN	CBX2	physical	22325352
CBX4_HUMAN	CBX4	physical	22325352
CBX6_HUMAN	CBX6	physical	22325352
CBX8_HUMAN	CBX8	physical	22325352
SCMH1_HUMAN	SCMH1	physical	22325352
SCML1_HUMAN	SCML1	physical	22325352

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHC3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-609; SER-616 ANDSER-762, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-315; THR-609; SER-616;SER-761 AND SER-762, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-609; THR-614 ANDSER-616, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-272 AND SER-274, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263; THR-609 ANDSER-616, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263; THR-609 ANDSER-616, AND MASS SPECTROMETRY.	15302935 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-609, AND MASSSPECTROMETRY.	16565220 [Abstract]