T126A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: T126A_HUMAN
• UniProt AC: Q9H061
• Protein Name: Transmembrane protein 126A
• Gene Name: TMEM126A
• Organism: Homo sapiens (Human).
• Sequence Length: 195
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Sequence: MENHKSNNKENITIVDISRKINQLPEAERNLLENGSVYVGLNAALCGLIANSLFRRILNVTKARIAAGLPMAGIPFLTTDLTYRCFVSFPLNTGDLDCETCTITRSGLTGLVIGGLYPVFLAIPVNGGLAARYQSALLPHKGNILSYWIRTSKPVFRKMLFPILLQTMFSAYLGSEQYKLLIKALQLSEPGKEIH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MENHKSNNKENIT --CCCCCCCCCCCEE	37.78	28102081
9	Malonylation	ENHKSNNKENITIVD CCCCCCCCCCEEEEE	57.28	26320211
9	Ubiquitination	ENHKSNNKENITIVD CCCCCCCCCCEEEEE	57.28	29967540
20	Ubiquitination	TIVDISRKINQLPEA EEEEHHHHHHCCCHH	38.94	-
52	Phosphorylation	LCGLIANSLFRRILN HHHHHHHHHHHHHHH	21.62	24719451
62	Malonylation	RRILNVTKARIAAGL HHHHHHHHHHHHCCC	31.24	26320211
62	2-Hydroxyisobutyrylation	RRILNVTKARIAAGL HHHHHHHHHHHHCCC	31.24	-
62	Ubiquitination	RRILNVTKARIAAGL HHHHHHHHHHHHCCC	31.24	-
109	Ubiquitination	TITRSGLTGLVIGGL EEECCCCCEEEECCE	31.81	22817900
113	Ubiquitination	SGLTGLVIGGLYPVF CCCCEEEECCEEEEE	4.33	21890473
122	Ubiquitination	GLYPVFLAIPVNGGL CEEEEEEEEEECCCH	7.80	21890473
153	Malonylation	SYWIRTSKPVFRKML HHHHHCCCHHHHHHH	44.58	32601280
167	Phosphorylation	LFPILLQTMFSAYLG HHHHHHHHHHHHHHC	21.83	25072903
170	Phosphorylation	ILLQTMFSAYLGSEQ HHHHHHHHHHHCCHH	12.75	25072903
172	Phosphorylation	LQTMFSAYLGSEQYK HHHHHHHHHCCHHHH	15.48	25072903
175	Phosphorylation	MFSAYLGSEQYKLLI HHHHHHCCHHHHHHH	20.94	25072903
178	Phosphorylation	AYLGSEQYKLLIKAL HHHCCHHHHHHHHHH	10.27	25072903
179	Ubiquitination	YLGSEQYKLLIKALQ HHCCHHHHHHHHHHH	36.19	22817900
183	Ubiquitination	EQYKLLIKALQLSEP HHHHHHHHHHHCCCC	42.91	22817900
188	Phosphorylation	LIKALQLSEPGKEIH HHHHHHCCCCCCCCC	28.87	24641631
192	Ubiquitination	LQLSEPGKEIH---- HHCCCCCCCCC----	65.30	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of T126A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of T126A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of T126A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of T126A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• H01020: Optic atrophy (OPA)
• OMIM Disease
• 612989: Optic atrophy 7 with or without auditory neuropathy (OPA7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.