SERPH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SERPH_HUMAN
• UniProt AC: P50454
• Protein Name: Serpin H1
• Gene Name: SERPINH1
• Organism: Homo sapiens (Human).
• Sequence Length: 418
• Subcellular Localization: Endoplasmic reticulum lumen.
• Protein Description: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen..
• Protein Sequence: MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	ALAAEVKKPAAAAAP HHHHHCCCCHHHCCC	45.10	-
32	Phosphorylation	AAAAAPGTAEKLSPK HHHCCCCCHHHHCHH	30.50	25159151
35	Ubiquitination	AAPGTAEKLSPKAAT CCCCCHHHHCHHHHH	52.37	-
35	2-Hydroxyisobutyrylation	AAPGTAEKLSPKAAT CCCCCHHHHCHHHHH	52.37	-
37	Phosphorylation	PGTAEKLSPKAATLA CCCHHHHCHHHHHHH	35.11	25159151
39	Ubiquitination	TAEKLSPKAATLAER CHHHHCHHHHHHHHH	47.48	21890473
39	2-Hydroxyisobutyrylation	TAEKLSPKAATLAER CHHHHCHHHHHHHHH	47.48	-
39	Malonylation	TAEKLSPKAATLAER CHHHHCHHHHHHHHH	47.48	26320211
47	Phosphorylation	AATLAERSAGLAFSL HHHHHHHHHHHHHHH	20.42	20068231
53	Phosphorylation	RSAGLAFSLYQAMAK HHHHHHHHHHHHHHH	22.14	22210691
53	O-linked_Glycosylation	RSAGLAFSLYQAMAK HHHHHHHHHHHHHHH	22.14	23301498
55	Phosphorylation	AGLAFSLYQAMAKDQ HHHHHHHHHHHHHCH	7.94	20068231
70	Phosphorylation	AVENILVSPVVVASS HHHHHCCCHHHHHHH	14.45	20068231
76	Phosphorylation	VSPVVVASSLGLVSL CCHHHHHHHCCCEEC	17.93	20068231
77	Phosphorylation	SPVVVASSLGLVSLG CHHHHHHHCCCEECC	19.40	20068231
82	Phosphorylation	ASSLGLVSLGGKATT HHHCCCEECCCCCCH	26.75	20068231
94	Succinylation	ATTASQAKAVLSAEQ CCHHHHHHHHHCHHH	31.24	-
94	Ubiquitination	ATTASQAKAVLSAEQ CCHHHHHHHHHCHHH	31.24	21890473
94	2-Hydroxyisobutyrylation	ATTASQAKAVLSAEQ CCHHHHHHHHHCHHH	31.24	-
94	Succinylation	ATTASQAKAVLSAEQ CCHHHHHHHHHCHHH	31.24	21890473
98	Phosphorylation	SQAKAVLSAEQLRDE HHHHHHHCHHHHCHH	24.14	20068231
120	N-linked_Glycosylation	ELLRSLSNSTARNVT HHHHHHCCCCCCCCC	48.99	20068230
120	N-linked_Glycosylation	ELLRSLSNSTARNVT HHHHHHCCCCCCCCC	48.99	20068230
125	N-linked_Glycosylation	LSNSTARNVTWKLGS HCCCCCCCCCEECCC	32.86	UniProtKB CARBOHYD
129	Ubiquitination	TARNVTWKLGSRLYG CCCCCCEECCCCCCC	33.34	-
132	Phosphorylation	NVTWKLGSRLYGPSS CCCEECCCCCCCCCC	29.55	26434776
135	Phosphorylation	WKLGSRLYGPSSVSF EECCCCCCCCCCCHH	26.36	28152594
138	Phosphorylation	GSRLYGPSSVSFADD CCCCCCCCCCHHHHH	38.72	28152594
139	Phosphorylation	SRLYGPSSVSFADDF CCCCCCCCCHHHHHH	25.55	28152594
141	Phosphorylation	LYGPSSVSFADDFVR CCCCCCCHHHHHHHH	19.37	21712546
149	Phosphorylation	FADDFVRSSKQHYNC HHHHHHHHCCCHHCC	36.26	27251275
150	Phosphorylation	ADDFVRSSKQHYNCE HHHHHHHCCCHHCCC	26.27	-
151	Ubiquitination	DDFVRSSKQHYNCEH HHHHHHCCCHHCCCC	42.20	-
151	2-Hydroxyisobutyrylation	DDFVRSSKQHYNCEH HHHHHHCCCHHCCCC	42.20	-
154	Phosphorylation	VRSSKQHYNCEHSKI HHHCCCHHCCCCCCC	21.00	-
159	Phosphorylation	QHYNCEHSKINFRDK CHHCCCCCCCCHHHH	16.97	-
160	Ubiquitination	HYNCEHSKINFRDKR HHCCCCCCCCHHHHH	43.51	-
160	Acetylation	HYNCEHSKINFRDKR HHCCCCCCCCHHHHH	43.51	26051181
172	Phosphorylation	DKRSALQSINEWAAQ HHHHHHHHHHHHHCC	28.38	30257219
180	Phosphorylation	INEWAAQTTDGKLPE HHHHHCCCCCCCCCC	23.33	30257219
181	Phosphorylation	NEWAAQTTDGKLPEV HHHHCCCCCCCCCCC	30.58	30257219
184	Ubiquitination	AAQTTDGKLPEVTKD HCCCCCCCCCCCCCC	64.77	21890473
184	2-Hydroxyisobutyrylation	AAQTTDGKLPEVTKD HCCCCCCCCCCCCCC	64.77	-
190	Ubiquitination	GKLPEVTKDVERTDG CCCCCCCCCCHHCCC	66.02	-
190	2-Hydroxyisobutyrylation	GKLPEVTKDVERTDG CCCCCCCCCCHHCCC	66.02	-
190	Acetylation	GKLPEVTKDVERTDG CCCCCCCCCCHHCCC	66.02	27452117
204	Sulfoxidation	GALLVNAMFFKPHWD CEEEEEEEEECCCCC	3.24	30846556
207	Acetylation	LVNAMFFKPHWDEKF EEEEEEECCCCCHHH	25.38	26051181
207	Ubiquitination	LVNAMFFKPHWDEKF EEEEEEECCCCCHHH	25.38	21890473
213	Ubiquitination	FKPHWDEKFHHKMVD ECCCCCHHHHHHEEC	47.74	-
217	Ubiquitination	WDEKFHHKMVDNRGF CCHHHHHHEECCCCE	31.86	-
217	2-Hydroxyisobutyrylation	WDEKFHHKMVDNRGF CCHHHHHHEECCCCE	31.86	-
217	Acetylation	WDEKFHHKMVDNRGF CCHHHHHHEECCCCE	31.86	26210075
230	Phosphorylation	GFMVTRSYTVGVMMM CEEEECEEEEEEEEE	11.36	-
240	Phosphorylation	GVMMMHRTGLYNYYD EEEEEECCCCCCCCC	19.50	26356563
243	Phosphorylation	MMHRTGLYNYYDDEK EEECCCCCCCCCCHH	11.49	28152594
245	Phosphorylation	HRTGLYNYYDDEKEK ECCCCCCCCCCHHHH	8.50	28152594
246	Phosphorylation	RTGLYNYYDDEKEKL CCCCCCCCCCHHHHE	17.18	28152594
250	Ubiquitination	YNYYDDEKEKLQIVE CCCCCCHHHHEEEEE	68.12	21906983
250	Sumoylation	YNYYDDEKEKLQIVE CCCCCCHHHHEEEEE	68.12	-
250	Acetylation	YNYYDDEKEKLQIVE CCCCCCHHHHEEEEE	68.12	23236377
252	Ubiquitination	YYDDEKEKLQIVEMP CCCCHHHHEEEEECH	57.68	-
252	2-Hydroxyisobutyrylation	YYDDEKEKLQIVEMP CCCCHHHHEEEEECH	57.68	-
258	Sulfoxidation	EKLQIVEMPLAHKLS HHEEEEECHHHHHHH	1.98	30846556
263	Methylation	VEMPLAHKLSSLIIL EECHHHHHHHHHHHH	44.44	115981473
271	Sulfoxidation	LSSLIILMPHHVEPL HHHHHHHCCCCCCHH	1.77	30846556
283	Ubiquitination	EPLERLEKLLTKEQL CHHHHHHHHCCHHHH	54.08	-
283	Acetylation	EPLERLEKLLTKEQL CHHHHHHHHCCHHHH	54.08	27452117
287	Ubiquitination	RLEKLLTKEQLKIWM HHHHHCCHHHHHHHH	43.35	-
287	2-Hydroxyisobutyrylation	RLEKLLTKEQLKIWM HHHHHCCHHHHHHHH	43.35	-
287	Malonylation	RLEKLLTKEQLKIWM HHHHHCCHHHHHHHH	43.35	26320211
287	Acetylation	RLEKLLTKEQLKIWM HHHHHCCHHHHHHHH	43.35	25953088
287	Succinylation	RLEKLLTKEQLKIWM HHHHHCCHHHHHHHH	43.35	23954790
291	Ubiquitination	LLTKEQLKIWMGKMQ HCCHHHHHHHHHHCC	33.73	-
291	2-Hydroxyisobutyrylation	LLTKEQLKIWMGKMQ HCCHHHHHHHHHHCC	33.73	-
291	Malonylation	LLTKEQLKIWMGKMQ HCCHHHHHHHHHHCC	33.73	30639696
296	Succinylation	QLKIWMGKMQKKAVA HHHHHHHHCCCCEEE	23.27	-
296	Ubiquitination	QLKIWMGKMQKKAVA HHHHHHHHCCCCEEE	23.27	-
296	2-Hydroxyisobutyrylation	QLKIWMGKMQKKAVA HHHHHHHHCCCCEEE	23.27	-
296	Malonylation	QLKIWMGKMQKKAVA HHHHHHHHCCCCEEE	23.27	30639696
296	Succinylation	QLKIWMGKMQKKAVA HHHHHHHHCCCCEEE	23.27	-
300	Ubiquitination	WMGKMQKKAVAISLP HHHHCCCCEEEEECC	31.07	-
300	2-Hydroxyisobutyrylation	WMGKMQKKAVAISLP HHHHCCCCEEEEECC	31.07	-
305	Phosphorylation	QKKAVAISLPKGVVE CCCEEEEECCCCCEE	28.96	24719451
308	Ubiquitination	AVAISLPKGVVEVTH EEEEECCCCCEEHHH	70.41	-
308	2-Hydroxyisobutyrylation	AVAISLPKGVVEVTH EEEEECCCCCEEHHH	70.41	-
319	Acetylation	EVTHDLQKHLAGLGL EHHHHHHHHHCCCCH	48.13	26210075
319	Ubiquitination	EVTHDLQKHLAGLGL EHHHHHHHHHCCCCH	48.13	21890473
319	2-Hydroxyisobutyrylation	EVTHDLQKHLAGLGL EHHHHHHHHHCCCCH	48.13	-
332	Ubiquitination	GLTEAIDKNKADLSR CHHHHHHHCHHHHHH	54.99	-
332	2-Hydroxyisobutyrylation	GLTEAIDKNKADLSR CHHHHHHHCHHHHHH	54.99	-
332	Acetylation	GLTEAIDKNKADLSR CHHHHHHHCHHHHHH	54.99	26051181
334	Ubiquitination	TEAIDKNKADLSRMS HHHHHHCHHHHHHHC	49.36	-
334	2-Hydroxyisobutyrylation	TEAIDKNKADLSRMS HHHHHHCHHHHHHHC	49.36	-
334	Malonylation	TEAIDKNKADLSRMS HHHHHHCHHHHHHHC	49.36	26320211
380	Ubiquitination	REELRSPKLFYADHP CHHHCCCCEEECCCC	53.10	21890473
380	Ubiquitination	REELRSPKLFYADHP CHHHCCCCEEECCCC	53.10	22053931
383	Phosphorylation	LRSPKLFYADHPFIF HCCCCEEECCCCEEE	22.89	-
395	Phosphorylation	FIFLVRDTQSGSLLF EEEEEECCCCCCEEE	17.67	21712546
397	Phosphorylation	FLVRDTQSGSLLFIG EEEECCCCCCEEEEE	32.23	21712546
399	Phosphorylation	VRDTQSGSLLFIGRL EECCCCCCEEEEEEE	27.44	23911959

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SERPH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SERPH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SERPH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBQL4_HUMAN	UBQLN4	physical	11162551
KLF13_HUMAN	KLF13	physical	11748222
S35F6_HUMAN	SLC35F6	physical	16169070
P53_HUMAN	TP53	physical	17977830
H15_HUMAN	HIST1H1B	physical	11581402
BRCA2_HUMAN	BRCA2	physical	19578754
ZEB1_HUMAN	ZEB1	physical	17546044
RCOR1_HUMAN	RCOR1	physical	17546044
HDAC2_HUMAN	HDAC2	physical	17546044
CTBP1_HUMAN	CTBP1	physical	17546044
FEZ1_HUMAN	FEZ1	physical	21900206
NSG2_HUMAN	HMP19	physical	21900206
CEP70_HUMAN	CEP70	physical	21900206
BAG6_HUMAN	BAG6	physical	21900206
UBL4A_HUMAN	UBL4A	physical	22939629
STX7_HUMAN	STX7	physical	22939629
TBL2_HUMAN	TBL2	physical	22939629
SUGP1_HUMAN	SUGP1	physical	22939629
YTHD1_HUMAN	YTHDF1	physical	22939629
TMED9_HUMAN	TMED9	physical	22939629
STAM1_HUMAN	STAM	physical	22939629
TIM44_HUMAN	TIMM44	physical	22939629
MPLKI_HUMAN	MPLKIP	physical	22939629
SOSB1_HUMAN	NABP2	physical	22939629
TPX2_HUMAN	TPX2	physical	22939629
ZC11A_HUMAN	ZC3H11A	physical	22939629
TPM4_HUMAN	TPM4	physical	22939629
UBE2B_HUMAN	UBE2B	physical	22939629
TRIP6_HUMAN	TRIP6	physical	22939629
VDAC3_HUMAN	VDAC3	physical	22939629
TM1L2_HUMAN	TOM1L2	physical	22939629
TOM40_HUMAN	TOMM40	physical	22939629
ZFR_HUMAN	ZFR	physical	22939629
SPEB_HUMAN	AGMAT	physical	22939629
ATX10_HUMAN	ATXN10	physical	22863883
VIME_HUMAN	VIM	physical	22863883
COF1_HUMAN	CFL1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613848: Osteogenesis imperfecta 10 (OI10)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.