SPEB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPEB_HUMAN
• UniProt AC: Q9BSE5
• Protein Name: Agmatinase, mitochondrial
• Gene Name: AGMAT
• Organism: Homo sapiens (Human).
• Sequence Length: 352
• Subcellular Localization: Mitochondrion.
• Protein Sequence: MLRLLASGCARGPGPGVGARPAAGLFHPGRRQSRQASDAPRNQPPSPEFVARPVGVCSMMRLPVQTSPEGLDAAFIGVPLDTGTSNRPGARFGPRRIREESVMLGTVNPSTGALPFQSLMVADLGDVNVNLYNLQDSCRRIQEAYEKIVAAGCIPLTLGGDHTITYPILQAMAKKHGPVGLLHVDAHTDTTDKALGEKLYHGAPFRRCVDEGLLDCKRVVQIGIRGSSTTLDPYRYNRSQGFRVVLAEDCWMKSLVPLMGEVRQQMGGKPIYISFDIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVMGCDLVEVSPPYDLSGNTALLAANLLFEMLCALPKVTTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	APRNQPPSPEFVARP CCCCCCCCHHHHCCC	43.68	20873877
67	Phosphorylation	MRLPVQTSPEGLDAA EECCCCCCCCCCCEE	12.12	28857561
188	Phosphorylation	LLHVDAHTDTTDKAL EEEEECCCCCCCHHH	36.44	20068231
190	Phosphorylation	HVDAHTDTTDKALGE EEECCCCCCCHHHHH	37.74	20068231
191	Phosphorylation	VDAHTDTTDKALGEK EECCCCCCCHHHHHH	38.01	20068231
193	Acetylation	AHTDTTDKALGEKLY CCCCCCCHHHHHHHC	43.34	-
217	Acetylation	DEGLLDCKRVVQIGI CCCCCCCCEEEEEEC	48.14	70971
217	Succinylation	DEGLLDCKRVVQIGI CCCCCCCCEEEEEEC	48.14	-
217	Succinylation	DEGLLDCKRVVQIGI CCCCCCCCEEEEEEC	48.14	-
227	Phosphorylation	VQIGIRGSSTTLDPY EEEECCCCCCCCCCC	18.05	28857561
230	Phosphorylation	GIRGSSTTLDPYRYN ECCCCCCCCCCCCCC	30.98	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPEB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPEB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPEB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLPX_HUMAN	CLPX	physical	26186194
RMD5A_HUMAN	RMND5A	physical	26186194
B3GL2_HUMAN	B3GALNT2	physical	26186194
BTBD1_HUMAN	BTBD1	physical	28514442
ACAD9_HUMAN	ACAD9	physical	28514442
SEC20_HUMAN	BNIP1	physical	27173435
WDR5_HUMAN	WDR5	physical	27173435
UGGG2_HUMAN	UGGT2	physical	27173435
TRI56_HUMAN	TRIM56	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.