B3GL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B3GL2_HUMAN
• UniProt AC: Q8NCR0
• Protein Name: UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2
• Gene Name: B3GALNT2
• Organism: Homo sapiens (Human).
• Sequence Length: 500
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein. Endoplasmic reticulum .
• Protein Description: Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O-glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O-mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan, which is required for binding laminin G-like domain-containing extracellular proteins with high affinity..
• Protein Sequence: MRNWLVLLCPCVLGAALHLWLRLRSPPPACASGAGPADQLALFPQWKSTHYDVVVGVLSARNNHELRNVIRSTWMRHLLQHPTLSQRVLVKFIIGAHGCEVPVEDREDPYSCKLLNITNPVLNQEIEAFSLSEDTSSGLPEDRVVSVSFRVLYPIVITSLGVFYDANDVGFQRNITVKLYQAEQEEALFIARFSPPSCGVQVNKLWYKPVEQFILPESFEGTIVWESQDLHGLVSRNLHKVTVNDGGGVLRVITAGEGALPHEFLEGVEGVAGGFIYTIQEGDALLHNLHSRPQRLIDHIRNLHEEDALLKEESSIYDDIVFVDVVDTYRNVPAKLLNFYRWTVETTSFNLLLKTDDDCYIDLEAVFNRIVQKNLDGPNFWWGNFRLNWAVDRTGKWQELEYPSPAYPAFACGSGYVISKDIVKWLASNSGRLKTYQGEDVSMGIWMAAIGPKRYQDSLWLCEKTCETGMLSSPQYSPWELTELWKLKERCGDPCRCQAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
116	N-linked_Glycosylation	PYSCKLLNITNPVLN CCCCEEEECCCCCCC	49.85	UniProtKB CARBOHYD
146	Phosphorylation	LPEDRVVSVSFRVLY CCCCCEEEEEEEEHH	14.80	26074081
148	Phosphorylation	EDRVVSVSFRVLYPI CCCEEEEEEEEHHHH	10.38	24719451
153	Phosphorylation	SVSFRVLYPIVITSL EEEEEEHHHHEEEEE	6.51	26074081
158	Phosphorylation	VLYPIVITSLGVFYD EHHHHEEEEEEEEEC	13.65	26074081
159	Phosphorylation	LYPIVITSLGVFYDA HHHHEEEEEEEEECC	16.41	26074081
164	Phosphorylation	ITSLGVFYDANDVGF EEEEEEEECCCCCCC	16.25	26074081
174	N-linked_Glycosylation	NDVGFQRNITVKLYQ CCCCCCCCEEEEEEE	24.41	UniProtKB CARBOHYD
240	Ubiquitination	LVSRNLHKVTVNDGG HHCCCCEEEEEECCC	42.65	27667366
281	Ubiquitination	GFIYTIQEGDALLHN EEEEEEECCCHHHHC	56.01	27667366
335	Ubiquitination	TYRNVPAKLLNFYRW HCCCCCHHHHHEEEE	47.65	22817900
335 (in isoform 1)	Ubiquitination	-	47.65	21890473
376	Ubiquitination	RIVQKNLDGPNFWWG HHHHHCCCCCCCCCC	78.77	21890473
376 (in isoform 2)	Ubiquitination	-	78.77	21890473
428	Phosphorylation	DIVKWLASNSGRLKT HHHHHHHHCCCCCCE	29.38	26699800
430	Phosphorylation	VKWLASNSGRLKTYQ HHHHHHCCCCCCEEC	23.85	26699800

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B3GL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B3GL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B3GL2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of B3GL2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615181: Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A11 (MDDGA11)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.