VDAC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VDAC3_HUMAN
• UniProt AC: Q9Y277
• Protein Name: Voltage-dependent anion-selective channel protein 3
• Gene Name: VDAC3
• Organism: Homo sapiens (Human).
• Sequence Length: 283
• Subcellular Localization: Mitochondrion outer membrane.
• Protein Description: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules..
• Protein Sequence: MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYKRDCFSVGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNEKIETSINLAWTAGSNNTRFGIAAKYMLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFSAGGHKVGLGFELEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MCNTPTYCD ------CCCCCCCCC	8.58	25944712
4	Phosphorylation	----MCNTPTYCDLG ----CCCCCCCCCHH	16.45	23401153
6	Phosphorylation	--MCNTPTYCDLGKA --CCCCCCCCCHHHH	34.44	23663014
7	Phosphorylation	-MCNTPTYCDLGKAA -CCCCCCCCCHHHHH	5.79	23663014
12	Acetylation	PTYCDLGKAAKDVFN CCCCCHHHHHHHHHH	53.09	23749302
12	Ubiquitination	PTYCDLGKAAKDVFN CCCCCHHHHHHHHHH	53.09	23000965
12	Malonylation	PTYCDLGKAAKDVFN CCCCCHHHHHHHHHH	53.09	26320211
15	Acetylation	CDLGKAAKDVFNKGY CCHHHHHHHHHHCCC	60.32	23749302
15	Ubiquitination	CDLGKAAKDVFNKGY CCHHHHHHHHHHCCC	60.32	23000965
15	Malonylation	CDLGKAAKDVFNKGY CCHHHHHHHHHHCCC	60.32	26320211
20	Acetylation	AAKDVFNKGYGFGMV HHHHHHHCCCCCEEE	41.88	19608861
20	Succinylation	AAKDVFNKGYGFGMV HHHHHHHCCCCCEEE	41.88	-
20	Ubiquitination	AAKDVFNKGYGFGMV HHHHHHHCCCCCEEE	41.88	23000965
20 (in isoform 2)	Ubiquitination	-	41.88	21890473
20	Malonylation	AAKDVFNKGYGFGMV HHHHHHHCCCCCEEE	41.88	26320211
20 (in isoform 1)	Ubiquitination	-	41.88	21890473
21	Ubiquitination	AKDVFNKGYGFGMVK HHHHHHCCCCCEEEE	28.97	22817900
22	Phosphorylation	KDVFNKGYGFGMVKI HHHHHCCCCCEEEEE	15.76	-
28	Acetylation	GYGFGMVKIDLKTKS CCCCEEEEEEECCCC	22.93	19608861
28	Ubiquitination	GYGFGMVKIDLKTKS CCCCEEEEEEECCCC	22.93	22817900
28	Malonylation	GYGFGMVKIDLKTKS CCCCEEEEEEECCCC	22.93	26320211
28 (in isoform 1)	Ubiquitination	-	22.93	21890473
28 (in isoform 2)	Ubiquitination	-	22.93	21890473
29	Ubiquitination	YGFGMVKIDLKTKSC CCCEEEEEEECCCCC	5.22	27667366
32	Ubiquitination	GMVKIDLKTKSCSGV EEEEEEECCCCCCCC	50.59	22817900
33	Phosphorylation	MVKIDLKTKSCSGVE EEEEEECCCCCCCCE	35.17	23312004
34	Ubiquitination	VKIDLKTKSCSGVEF EEEEECCCCCCCCEE	48.13	33845483
34	Acetylation	VKIDLKTKSCSGVEF EEEEECCCCCCCCEE	48.13	26051181
35	Phosphorylation	KIDLKTKSCSGVEFS EEEECCCCCCCCEEE	20.81	26437602
35 (in isoform 2)	Phosphorylation	-	20.81	26437602
37	Phosphorylation	DLKTKSCSGVEFSTS EECCCCCCCCEEECC	53.62	23312004
42	Phosphorylation	SCSGVEFSTSGHAYT CCCCCEEECCCEEEE	14.25	28152594
43	Phosphorylation	CSGVEFSTSGHAYTD CCCCEEECCCEEEEC	44.01	28152594
43 (in isoform 2)	Phosphorylation	-	44.01	-
44	Phosphorylation	SGVEFSTSGHAYTDT CCCEEECCCEEEECC	27.64	28152594
44 (in isoform 2)	Phosphorylation	-	27.64	-
45 (in isoform 2)	Phosphorylation	-	14.99	20833797
48	Phosphorylation	FSTSGHAYTDTGKAS EECCCEEEECCCCCC	10.24	28152594
49	Phosphorylation	STSGHAYTDTGKASG ECCCEEEECCCCCCC	28.06	28152594
49 (in isoform 2)	Phosphorylation	-	28.06	26437602
50 (in isoform 2)	Phosphorylation	-	40.56	-
51	Phosphorylation	SGHAYTDTGKASGNL CCEEEECCCCCCCCC	32.55	28152594
53	Ubiquitination	HAYTDTGKASGNLET EEEECCCCCCCCCCC	41.28	21906983
53	Neddylation	HAYTDTGKASGNLET EEEECCCCCCCCCCC	41.28	32015554
53	Acetylation	HAYTDTGKASGNLET EEEECCCCCCCCCCC	41.28	26051181
53 (in isoform 1)	Ubiquitination	-	41.28	21890473
54	Ubiquitination	AYTDTGKASGNLETK EEECCCCCCCCCCCE	24.82	22817900
55	Phosphorylation	YTDTGKASGNLETKY EECCCCCCCCCCCEE	31.53	26437602
56 (in isoform 2)	Phosphorylation	-	47.83	26437602
61	Acetylation	ASGNLETKYKVCNYG CCCCCCCEEEEECCC	33.43	25825284
61	Ubiquitination	ASGNLETKYKVCNYG CCCCCCCEEEEECCC	33.43	25621951
62	Ubiquitination	SGNLETKYKVCNYGL CCCCCCEEEEECCCC	18.97	32142685
62	Phosphorylation	SGNLETKYKVCNYGL CCCCCCEEEEECCCC	18.97	29496907
62	Acetylation	SGNLETKYKVCNYGL CCCCCCEEEEECCCC	18.97	19608861
63	Acetylation	GNLETKYKVCNYGLT CCCCCEEEEECCCCE	41.70	23954790
63	Ubiquitination	GNLETKYKVCNYGLT CCCCCEEEEECCCCE	41.70	33845483
63	Malonylation	GNLETKYKVCNYGLT CCCCCEEEEECCCCE	41.70	26320211
64	Ubiquitination	NLETKYKVCNYGLTF CCCCEEEEECCCCEE	2.02	33845483
64	Acetylation	NLETKYKVCNYGLTF CCCCEEEEECCCCEE	2.02	19608861
65	S-nitrosocysteine	LETKYKVCNYGLTFT CCCEEEEECCCCEEE	2.58	-
65	S-nitrosylation	LETKYKVCNYGLTFT CCCEEEEECCCCEEE	2.58	20140087
67	Phosphorylation	TKYKVCNYGLTFTQK CEEEEECCCCEEEEE	14.37	28152594
70	Phosphorylation	KVCNYGLTFTQKWNT EEECCCCEEEEEECC	21.92	28152594
72	Phosphorylation	CNYGLTFTQKWNTDN ECCCCEEEEEECCCC	24.81	28152594
77	Ubiquitination	TFTQKWNTDNTLGTE EEEEEECCCCCCCCE	29.52	21890473
78	Ubiquitination	FTQKWNTDNTLGTEI EEEEECCCCCCCCEE	42.79	22817900
81	Ubiquitination	KWNTDNTLGTEISWE EECCCCCCCCEEEEC	11.37	22817900
83	Ubiquitination	NTDNTLGTEISWENK CCCCCCCCEEEECHH	33.00	27667366
86	Phosphorylation	NTLGTEISWENKLAE CCCCCEEEECHHHHH	23.31	30387612
90	Acetylation	TEISWENKLAEGLKL CEEEECHHHHHCCEE	37.24	19608861
90	Ubiquitination	TEISWENKLAEGLKL CEEEECHHHHHCCEE	37.24	29967540
91	Ubiquitination	EISWENKLAEGLKLT EEEECHHHHHCCEEE	8.71	29967540
91	Acetylation	EISWENKLAEGLKLT EEEECHHHHHCCEEE	8.71	19608861
96	Acetylation	NKLAEGLKLTLDTIF HHHHHCCEEEEEEEE	50.73	25953088
98	Phosphorylation	LAEGLKLTLDTIFVP HHHCCEEEEEEEECC	22.47	24641631
107	Phosphorylation	DTIFVPNTGKKSGKL EEEECCCCCCCCCCE	44.29	28555341
109	Acetylation	IFVPNTGKKSGKLKA EECCCCCCCCCCEEE	41.55	25953088
109	Ubiquitination	IFVPNTGKKSGKLKA EECCCCCCCCCCEEE	41.55	21906983
109	Malonylation	IFVPNTGKKSGKLKA EECCCCCCCCCCEEE	41.55	26320211
109 (in isoform 1)	Ubiquitination	-	41.55	21890473
110	Acetylation	FVPNTGKKSGKLKAS ECCCCCCCCCCEEEE	66.83	30583797
110	Ubiquitination	FVPNTGKKSGKLKAS ECCCCCCCCCCEEEE	66.83	32142685
110 (in isoform 2)	Ubiquitination	-	66.83	21890473
111	Ubiquitination	VPNTGKKSGKLKASY CCCCCCCCCCEEEEE	44.65	22817900
113	Acetylation	NTGKKSGKLKASYKR CCCCCCCCEEEEEEC	54.64	30583803
113	Ubiquitination	NTGKKSGKLKASYKR CCCCCCCCEEEEEEC	54.64	22817900
114	Ubiquitination	TGKKSGKLKASYKRD CCCCCCCEEEEEECC	6.81	22817900
115	Acetylation	GKKSGKLKASYKRDC CCCCCCEEEEEECCC	38.48	7706155
115	Ubiquitination	GKKSGKLKASYKRDC CCCCCCEEEEEECCC	38.48	27667366
116	Ubiquitination	KKSGKLKASYKRDCF CCCCCEEEEEECCCE	28.64	27667366
117	Phosphorylation	KSGKLKASYKRDCFS CCCCEEEEEECCCEE	29.60	26437602
119	Acetylation	GKLKASYKRDCFSVG CCEEEEEECCCEECC	38.99	25953088
124	Phosphorylation	SYKRDCFSVGSNVDI EEECCCEECCCCEEE	31.72	23403867
127	Phosphorylation	RDCFSVGSNVDIDFS CCCEECCCCEEEECC	31.37	23403867
129	Ubiquitination	CFSVGSNVDIDFSGP CEECCCCEEEECCCC	7.95	22817900
131	Ubiquitination	SVGSNVDIDFSGPTI ECCCCEEEECCCCCE	5.12	21890473
134	Phosphorylation	SNVDIDFSGPTIYGW CCEEEECCCCCEEEE	39.86	26552605
137	Phosphorylation	DIDFSGPTIYGWAVL EEECCCCCEEEEEEE	30.29	26552605
139	Phosphorylation	DFSGPTIYGWAVLAF ECCCCCEEEEEEEEC	14.75	26552605
153	Phosphorylation	FEGWLAGYQMSFDTA CHHHHHHEEEEHHHH	8.74	26552605
156	Phosphorylation	WLAGYQMSFDTAKSK HHHHEEEEHHHHHHH	12.40	26552605
159	Phosphorylation	GYQMSFDTAKSKLSQ HEEEEHHHHHHHHHC	33.69	23403867
161	Ubiquitination	QMSFDTAKSKLSQNN EEEHHHHHHHHHCCC	50.66	22817900
162	Phosphorylation	MSFDTAKSKLSQNNF EEHHHHHHHHHCCCC	36.04	26437602
162	Ubiquitination	MSFDTAKSKLSQNNF EEHHHHHHHHHCCCC	36.04	22817900
163	Acetylation	SFDTAKSKLSQNNFA EHHHHHHHHHCCCCC	51.99	23954790
163	Ubiquitination	SFDTAKSKLSQNNFA EHHHHHHHHHCCCCC	51.99	22817900
163	Neddylation	SFDTAKSKLSQNNFA EHHHHHHHHHCCCCC	51.99	32015554
163	Malonylation	SFDTAKSKLSQNNFA EHHHHHHHHHCCCCC	51.99	26320211
163 (in isoform 1)	Ubiquitination	-	51.99	21890473
164	Ubiquitination	FDTAKSKLSQNNFAL HHHHHHHHHCCCCCC	9.10	22817900
164	Neddylation	FDTAKSKLSQNNFAL HHHHHHHHHCCCCCC	9.10	32015554
164 (in isoform 2)	Ubiquitination	-	9.10	21890473
165	Phosphorylation	DTAKSKLSQNNFALG HHHHHHHHCCCCCCE	34.30	26437602
173	Phosphorylation	QNNFALGYKAADFQL CCCCCCEEEEEEEEE	9.78	30377224
174	Acetylation	NNFALGYKAADFQLH CCCCCEEEEEEEEEE	34.99	23954790
174	Malonylation	NNFALGYKAADFQLH CCCCCEEEEEEEEEE	34.99	26320211
182	Phosphorylation	AADFQLHTHVNDGTE EEEEEEEEECCCCCC	35.79	29396449
188	Phosphorylation	HTHVNDGTEFGGSIY EEECCCCCCCCCHHH	30.88	26437602
195	Phosphorylation	TEFGGSIYQKVNEKI CCCCCHHHHHHHHHC	12.18	22817900
197	Ubiquitination	FGGSIYQKVNEKIET CCCHHHHHHHHHCCE	30.01	29967540
197	Acetylation	FGGSIYQKVNEKIET CCCHHHHHHHHHCCE	30.01	26051181
198	Ubiquitination	GGSIYQKVNEKIETS CCHHHHHHHHHCCEE	7.07	29967540
201	Acetylation	IYQKVNEKIETSINL HHHHHHHHCCEEEEE	40.41	26051181
211	Phosphorylation	TSINLAWTAGSNNTR EEEEEEEECCCCCCE	18.61	23090842
214	Phosphorylation	NLAWTAGSNNTRFGI EEEEECCCCCCEEEE	25.17	23090842
217	Phosphorylation	WTAGSNNTRFGIAAK EECCCCCCEEEEEEE	31.46	23090842
224	Acetylation	TRFGIAAKYMLDCRT CEEEEEEEHHHHCCC	23.36	25825284
234	Ubiquitination	LDCRTSLSAKVNNAS HHCCCCEEEEECCEE	26.30	21890473
236	Malonylation	CRTSLSAKVNNASLI CCCCEEEEECCEEEE	41.96	26320211
236	Acetylation	CRTSLSAKVNNASLI CCCCEEEEECCEEEE	41.96	26051181
241	Phosphorylation	SAKVNNASLIGLGYT EEEECCEEEEECCCC	23.73	28152594
242	Ubiquitination	AKVNNASLIGLGYTQ EEECCEEEEECCCCC	3.15	21890473
247	Phosphorylation	ASLIGLGYTQTLRPG EEEEECCCCCCCCCC	10.75	28152594
248	Phosphorylation	SLIGLGYTQTLRPGV EEEECCCCCCCCCCC	17.18	28152594
250	Phosphorylation	IGLGYTQTLRPGVKL EECCCCCCCCCCCEE	19.55	25159151
258	Phosphorylation	LRPGVKLTLSALIDG CCCCCEEEEEEEECC	16.98	21712546
260	Phosphorylation	PGVKLTLSALIDGKN CCCEEEEEEEECCCC	18.78	21712546
266	Acetylation	LSALIDGKNFSAGGH EEEEECCCCCCCCCC	51.58	26051181
266	Ubiquitination	LSALIDGKNFSAGGH EEEEECCCCCCCCCC	51.58	32015554
266	Malonylation	LSALIDGKNFSAGGH EEEEECCCCCCCCCC	51.58	26320211
266 (in isoform 1)	Ubiquitination	-	51.58	21890473
267	Ubiquitination	SALIDGKNFSAGGHK EEEECCCCCCCCCCE	41.45	21890473
267 (in isoform 2)	Ubiquitination	-	41.45	21890473
274	Ubiquitination	NFSAGGHKVGLGFEL CCCCCCCEEECEEEE	41.07	32142685
274	Neddylation	NFSAGGHKVGLGFEL CCCCCCCEEECEEEE	41.07	32015554
274	Acetylation	NFSAGGHKVGLGFEL CCCCCCCEEECEEEE	41.07	26051181
274 (in isoform 1)	Ubiquitination	-	41.07	21890473
275	Ubiquitination	FSAGGHKVGLGFELE CCCCCCEEECEEEEE	6.76	32142685
275	Neddylation	FSAGGHKVGLGFELE CCCCCCEEECEEEEE	6.76	32015554
275 (in isoform 2)	Ubiquitination	-	6.76	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VDAC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VDAC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VDAC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YMEL1_HUMAN	YME1L1	physical	22939629
ATPA_HUMAN	ATP5A1	physical	26344197
ATPB_HUMAN	ATP5B	physical	26344197
ATPG_HUMAN	ATP5C1	physical	26344197
ATPD_HUMAN	ATP5D	physical	26344197
ATP5H_HUMAN	ATP5H	physical	26344197
ATP5I_HUMAN	ATP5I	physical	26344197
ATPO_HUMAN	ATP5O	physical	26344197
VA0D1_HUMAN	ATP6V0D1	physical	26344197
VATA_HUMAN	ATP6V1A	physical	26344197
BAP31_HUMAN	BCAP31	physical	26344197
CISD1_HUMAN	CISD1	physical	26344197
CISD2_HUMAN	CISD2	physical	26344197
CLH1_HUMAN	CLTC	physical	26344197
COX41_HUMAN	COX4I1	physical	26344197
COX5A_HUMAN	COX5A	physical	26344197
OST48_HUMAN	DDOST	physical	26344197
ILVBL_HUMAN	ILVBL	physical	26344197
MIC60_HUMAN	IMMT	physical	26344197
MAGT1_HUMAN	MAGT1	physical	26344197
NDUA9_HUMAN	NDUFA9	physical	26344197
NDUB7_HUMAN	NDUFB7	physical	26344197
NDUB8_HUMAN	NDUFB8	physical	26344197
NDUS4_HUMAN	NDUFS4	physical	26344197
NDUS8_HUMAN	NDUFS8	physical	26344197
PHB_HUMAN	PHB	physical	26344197
PHB2_HUMAN	PHB2	physical	26344197
RPN1_HUMAN	RPN1	physical	26344197
SGPL1_HUMAN	SGPL1	physical	26344197
SSRA_HUMAN	SSR1	physical	26344197
SSRG_HUMAN	SSR3	physical	26344197
STX12_HUMAN	STX12	physical	26344197
STX7_HUMAN	STX7	physical	26344197
TECR_HUMAN	TECR	physical	26344197
TOM22_HUMAN	TOMM22	physical	26344197
TOM40_HUMAN	TOMM40	physical	26344197
TSPO_HUMAN	TSPO	physical	26344197
VAPA_HUMAN	VAPA	physical	26344197
APOE_HUMAN	APOE	physical	28514442
SRC_HUMAN	SRC	physical	28514442
RASH_HUMAN	HRAS	physical	28514442
ERIC5_HUMAN	ERICH5	physical	28514442
FA8A1_HUMAN	FAM8A1	physical	28514442
RAP2A_HUMAN	RAP2A	physical	28514442
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01375: Dihydroxyaluminium

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT CYS-2; LYS-20; LYS-28; LYS-61;LYS-63 AND LYS-90, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-195, AND MASSSPECTROMETRY.
PubMed: 15592455