MAGT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGT1_HUMAN
• UniProt AC: Q9H0U3
• Protein Name: Magnesium transporter protein 1
• Gene Name: MAGT1
• Organism: Homo sapiens (Human).
• Sequence Length: 335
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum . Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.; May be involved in Mg(2+) transport in epithelial cells..
• Protein Sequence: MAARWRFWCVSVTMVVALLIVCDVPSASAQRKKEMVLSEKVSQLMEWTNKRPVIRMNGDKFRRLVKAPPRNYSVIVMFTALQLHRQCVVCKQADEEFQILANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRGDTYELQVRGFSAEQIARWIADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNMEFLFNKTGWAFAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGHVNYIHGSSQAQFVAETHIVLLFNGGVTLGMVLLCEAATSDMDIGKRKIMCVAGIGLVVLFFSWMLSIFRSKYHGYPYSFLMS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Ubiquitination	KEMVLSEKVSQLMEW HHHHHHHHHHHHHHH	43.75	-
50	2-Hydroxyisobutyrylation	QLMEWTNKRPVIRMN HHHHHHCCCCEEEEC	51.18	-
50	Ubiquitination	QLMEWTNKRPVIRMN HHHHHHCCCCEEEEC	51.18	21890473
50	Ubiquitination	QLMEWTNKRPVIRMN HHHHHHCCCCEEEEC	51.18	-
65	Ubiquitination	GDKFRRLVKAPPRNY HHHHHHHHCCCCCCC	4.75	-
66	Ubiquitination	DKFRRLVKAPPRNYS HHHHHHHCCCCCCCE	60.82	-
71	N-linked_Glycosylation	LVKAPPRNYSVIVMF HHCCCCCCCEEEEEE	38.92	UniProtKB CARBOHYD
72	Phosphorylation	VKAPPRNYSVIVMFT HCCCCCCCEEEEEEE	12.95	-
72	Ubiquitination	VKAPPRNYSVIVMFT HCCCCCCCEEEEEEE	12.95	-
73	Phosphorylation	KAPPRNYSVIVMFTA CCCCCCCEEEEEEEH	14.66	-
79	Phosphorylation	YSVIVMFTALQLHRQ CEEEEEEEHHHHHHH	14.36	-
82	Ubiquitination	IVMFTALQLHRQCVV EEEEEHHHHHHHCEE	32.53	-
91	Ubiquitination	HRQCVVCKQADEEFQ HHHCEEECCCCHHHH	36.59	2190698
91	Ubiquitination	HRQCVVCKQADEEFQ HHHCEEECCCCHHHH	36.59	21890473
106	Phosphorylation	ILANSWRYSSAFTNR HHHHCCCCCHHHCCC	10.75	26437602
107	Phosphorylation	LANSWRYSSAFTNRI HHHCCCCCHHHCCCE	13.45	-
108	Phosphorylation	ANSWRYSSAFTNRIF HHCCCCCHHHCCCEE	20.61	26437602
111	Phosphorylation	WRYSSAFTNRIFFAM CCCCHHHCCCEEEEE	24.25	-
123	Ubiquitination	FAMVDFDEGSDVFQM EEEEECCCCCCHHHH	61.67	21890473
153	Phosphorylation	GKPKRGDTYELQVRG CCCCCCCEEEEEECC	23.01	-
162	Phosphorylation	ELQVRGFSAEQIARW EEEECCCCHHHHHHH	33.45	20860994
185	Phosphorylation	IRVIRPPNYAGPLML EEEECCCCCCHHHHH	41.80	-
194	Phosphorylation	AGPLMLGLLLAVIGG CHHHHHHHHHHHHHH	2.89	-
324	Ubiquitination	MLSIFRSKYHGYPYS HHHHHHHHHCCCCHH	36.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OST48_HUMAN	DDOST	physical	22939629
STT3B_HUMAN	STT3B	physical	22939629
RL6_HUMAN	RPL6	physical	22939629
PPIB_HUMAN	PPIB	physical	22939629
COX41_HUMAN	COX4I1	physical	26344197
SSRA_HUMAN	SSR1	physical	26344197
STT3B_HUMAN	STT3B	physical	26344197
TECR_HUMAN	TECR	physical	26344197
TECT2_HUMAN	TCTN2	physical	27173435
STT3B_HUMAN	STT3B	physical	28720733

Drug and Disease Associations

• Kegg Disease
• H00480: Non-syndromic X-linked mental retardation
• OMIM Disease
• 300853: Immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia (XMEN)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.