dbPTM

TECT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TECT2_HUMAN
UniProt AC	Q96GX1
Protein Name	Tectonic-2
Gene Name	TCTN2
Organism	Homo sapiens (Human).
Sequence Length	697
Subcellular Localization	Membrane Single-pass type I membrane protein . Cytoplasm, cytoskeleton, cilium basal body. Localizes at the transition zone, a region between the basal body and the ciliary axoneme..
Protein Description	Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for hedgehog signaling transduction (By similarity)..
Protein Sequence	MGFQPPAALLLRLFLLQGILRLLWGDLAFIPPFIRMSGPAVSASLVGDTEGVTVSLAVLQDEAGILPIPTCGVLNNETEDWSVTVIPGAKVLEVTVRWKRGLDWCSSNETDSFSESPCILQTLLVSASHNSSCSAHLLIQVEIYANSSLTHNASENVTVIPNQVYQPLGPCPCNLTAGACDVRCCCDQECSSNLTTLFRRSCFTGVFGGDVNPPFDQLCSAGTTTRGVPDWFPFLCVQSPLANTPFLGYFYHGAVSPKQDSSFEVYVDTDAKDFADFGYKQGDPIMTVKKAYFTIPQVSLAGQCMQNAPVAFLHNFDVKCVTNLELYQERDGIINAKIKNVALGGIVTPKVIYEEATDLDKFITNTETPLNNGSTPRIVNVEEHYIFKWNNNTISEINVKIFRAEINAHQKGIMTQRFVVKFLSYNSGNEEELSGNPGYQLGKPVRALNINRMNNVTTLHLWQSAGRGLCTSATFKPILFGENVLSGCLLEVGINENCTQLRENAVERLDSLIQATHVAMRGNSDYADLSDGWLEIIRVDAPDPGADPLASSVNGMCLDIPAHLSIRILISDAGAVEGITQQEILGVETRFSSVNWQYQCGLTCEHKADLLPISASVQFIKIPAQLPHPLTRFQINYTEYDCNRNEVCWPQLLYPWTQYYQGELHSQCVAKGLLLLLFLTLALFLSNPWTRICKAYS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
139	Ubiquitination	SCSAHLLIQVEIYAN CCCEEEEEEEEEEEC	5.62	22817900
146	N-linked_Glycosylation	IQVEIYANSSLTHNA EEEEEEECCCCCCCC	18.37	UniProtKB CARBOHYD
156	N-linked_Glycosylation	LTHNASENVTVIPNQ CCCCCCCCEEECCCC	32.06	UniProtKB CARBOHYD
279	Ubiquitination	KDFADFGYKQGDPIM HHHHHCCCCCCCCEE	10.51	29967540
280	Ubiquitination	DFADFGYKQGDPIMT HHHHCCCCCCCCEEE	48.46	29967540
327	Phosphorylation	CVTNLELYQERDGII ECCCCHHHHHCCCCH	10.04	-
349	Ubiquitination	ALGGIVTPKVIYEEA EECCCCCCHHHEEEC	20.30	29967540
350	Ubiquitination	LGGIVTPKVIYEEAT ECCCCCCHHHEEECC	31.72	29967540
391	N-linked_Glycosylation	HYIFKWNNNTISEIN EEEEEECCCCEEEEE	46.00	UniProtKB CARBOHYD
397	Ubiquitination	NNNTISEINVKIFRA CCCCEEEEEEEEEHH	6.00	22817900
398	Ubiquitination	NNTISEINVKIFRAE CCCEEEEEEEEEHHH	25.61	22817900
411	Ubiquitination	AEINAHQKGIMTQRF HHHHHHHCCCCHHHH	40.30	-
442	Ubiquitination	GNPGYQLGKPVRALN CCCCCCCCCCEEEEC	19.39	22817900
443	Ubiquitination	NPGYQLGKPVRALNI CCCCCCCCCEEEECC	49.27	22817900
497	N-linked_Glycosylation	LEVGINENCTQLREN EEEECCCCCHHHHHH	29.64	UniProtKB CARBOHYD
565	Phosphorylation	LDIPAHLSIRILISD CCCCCCEEEEEEECC	10.43	24719451
621	Ubiquitination	SASVQFIKIPAQLPH ECEEEEEECCCCCCC	43.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TECT2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TECT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TECT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AAAS_HUMAN	AAAS	physical	26638075
ABD12_HUMAN	ABHD12	physical	26638075
ACSL3_HUMAN	ACSL3	physical	26638075
PAQR1_HUMAN	ADIPOR1	physical	26638075
PAQR2_HUMAN	ADIPOR2	physical	26638075
PLCA_HUMAN	AGPAT1	physical	26638075
GPAT4_HUMAN	AGPAT6	physical	26638075
GPAT3_HUMAN	AGPAT9	physical	26638075
AL3A2_HUMAN	ALDH3A2	physical	26638075
ALG3_HUMAN	ALG3	physical	26638075
ALG9_HUMAN	ALG9	physical	26638075
ANO10_HUMAN	ANO10	physical	26638075
ANO6_HUMAN	ANO6	physical	26638075
APOL2_HUMAN	APOL2	physical	26638075
ARF5_HUMAN	ARF5	physical	26638075
RHG01_HUMAN	ARHGAP1	physical	26638075
PRAF3_HUMAN	ARL6IP5	physical	26638075
AT131_HUMAN	ATP13A1	physical	26638075
AT2A2_HUMAN	ATP2A2	physical	26638075
VAS1_HUMAN	ATP6AP1	physical	26638075
RENR_HUMAN	ATP6AP2	physical	26638075
VATF_HUMAN	ATP6V1F	physical	26638075
AUP1_HUMAN	AUP1	physical	26638075
BAP31_HUMAN	BCAP31	physical	26638075
BET1_HUMAN	BET1	physical	26638075
SEC20_HUMAN	BNIP1	physical	26638075
BRI3B_HUMAN	BRI3BP	physical	26638075
EMC7_HUMAN	EMC7	physical	26638075
EMC10_HUMAN	EMC10	physical	26638075
C1QBP_HUMAN	C1QBP	physical	26638075
TM230_HUMAN	TMEM230	physical	26638075
CAC1A_HUMAN	CACNA1A	physical	26638075
CAMLG_HUMAN	CAMLG	physical	26638075
CALX_HUMAN	CANX	physical	26638075
CC115_HUMAN	CCDC115	physical	26638075
CCD47_HUMAN	CCDC47	physical	26638075
CDKAL_HUMAN	CDKAL1	physical	26638075
CERS2_HUMAN	CERS2	physical	26638075
CISD2_HUMAN	CISD2	physical	26638075
CKAP4_HUMAN	CKAP4	physical	26638075
CLCC1_HUMAN	CLCC1	physical	26638075
CLGN_HUMAN	CLGN	physical	26638075
CLP1L_HUMAN	CLPTM1L	physical	26638075
EMC8_HUMAN	EMC8	physical	26638075
NB5R3_HUMAN	CYB5R3	physical	26638075
DAD1_HUMAN	DAD1	physical	26638075
OST48_HUMAN	DDOST	physical	26638075
DDRGK_HUMAN	DDRGK1	physical	26638075
DEP1B_HUMAN	DEPDC1B	physical	26638075
DGKE_HUMAN	DGKE	physical	26638075
DHCR7_HUMAN	DHCR7	physical	26638075
DHRS7_HUMAN	DHRS7	physical	26638075
DRS7B_HUMAN	DHRS7B	physical	26638075
DJB11_HUMAN	DNAJB11	physical	26638075
DNJC1_HUMAN	DNAJC1	physical	26638075
DJC16_HUMAN	DNAJC16	physical	26638075
DOPP1_HUMAN	DOLPP1	physical	26638075
EBP_HUMAN	EBP	physical	26638075
EMD_HUMAN	EMD	physical	26638075
ESYT1_HUMAN	ESYT1	physical	26638075
FADS2_HUMAN	FADS2	physical	26638075
FAF2_HUMAN	FAF2	physical	26638075
FKBP8_HUMAN	FKBP8	physical	26638075
GOSR2_HUMAN	GOSR2	physical	26638075
HM13_HUMAN	HM13	physical	26638075
HMOX2_HUMAN	HMOX2	physical	26638075
DHB12_HUMAN	HSD17B12	physical	26638075
ENPL_HUMAN	HSP90B1	physical	26638075
GRP78_HUMAN	HSPA5	physical	26638075
HYOU1_HUMAN	HYOU1	physical	26638075
IKIP_HUMAN	IKBIP	physical	26638075
ITB1_HUMAN	ITGB1	physical	26638075
JAGN1_HUMAN	JAGN1	physical	26638075
EMC1_HUMAN	EMC1	physical	26638075
LNP_HUMAN	KIAA1715	physical	26638075
KTAP2_HUMAN	KRTCAP2	physical	26638075
LBR_HUMAN	LBR	physical	26638075
MAN1_HUMAN	LEMD3	physical	26638075
LMAN1_HUMAN	LMAN1	physical	26638075
LMBRL_HUMAN	LMBR1L	physical	26638075
LMF2_HUMAN	LMF2	physical	26638075
LRC59_HUMAN	LRRC59	physical	26638075
MAGT1_HUMAN	MAGT1	physical	26638075
MBOA2_HUMAN	MBOAT2	physical	26638075
MBOA7_HUMAN	MBOAT7	physical	26638075
MFS10_HUMAN	MFSD10	physical	26638075
MKS1_HUMAN	MKS1	physical	26638075
MLEC_HUMAN	MLEC	physical	26638075
MMGT1_HUMAN	MMGT1	physical	26638075
NCOA2_HUMAN	NCOA2	physical	26638075
NDUA5_HUMAN	NDUFA5	physical	26638075
NDUS8_HUMAN	NDUFS8	physical	26638075
NSDHL_HUMAN	NSDHL	physical	26638075
NGBR_HUMAN	NUS1	physical	26638075
OSBL8_HUMAN	OSBPL8	physical	26638075
PDIA4_HUMAN	PDIA4	physical	26638075
PDIA6_HUMAN	PDIA6	physical	26638075
PGRC2_HUMAN	PGRMC2	physical	26638075
PIGS_HUMAN	PIGS	physical	26638075
PIGU_HUMAN	PIGU	physical	26638075
PLOD3_HUMAN	PLOD3	physical	26638075
NCPR_HUMAN	POR	physical	26638075
PRAF2_HUMAN	PRAF2	physical	26638075
PREB_HUMAN	PREB	physical	26638075
PTSS1_HUMAN	PTDSS1	physical	26638075
PTN1_HUMAN	PTPN1	physical	26638075
RAB10_HUMAN	RAB10	physical	26638075
RAB1A_HUMAN	RAB1A	physical	26638075
RAB31_HUMAN	RAB31	physical	26638075
RAB7A_HUMAN	RAB7A	physical	26638075
RABL3_HUMAN	RABL3	physical	26638075
REEP2_HUMAN	REEP2	physical	26638075
RER1_HUMAN	RER1	physical	26638075
RFT1_HUMAN	RFT1	physical	26638075
RHBD2_HUMAN	RHBDD2	physical	26638075
RPN1_HUMAN	RPN1	physical	26638075
RPN2_HUMAN	RPN2	physical	26638075
RTN3_HUMAN	RTN3	physical	26638075
SC11A_HUMAN	SEC11A	physical	26638075
SC11C_HUMAN	SEC11C	physical	26638075
SC22B_HUMAN	SEC22B	physical	26638075
SEC62_HUMAN	SEC62	physical	26638075
SEC63_HUMAN	SEC63	physical	26638075
SGPL1_HUMAN	SGPL1	physical	26638075
ACATN_HUMAN	SLC33A1	physical	26638075
S39A7_HUMAN	SLC39A7	physical	26638075
SNP47_HUMAN	SNAP47	physical	26638075
SNX19_HUMAN	SNX19	physical	26638075
SOAT1_HUMAN	SOAT1	physical	26638075
SPCS1_HUMAN	SPCS1	physical	26638075
SPCS2_HUMAN	SPCS2	physical	26638075
SPCS3_HUMAN	SPCS3	physical	26638075
SRPRA_HUMAN	SRPR	physical	26638075
SRPRB_HUMAN	SRPRB	physical	26638075
SSRG_HUMAN	SSR3	physical	26638075
STIM1_HUMAN	STIM1	physical	26638075
STT3B_HUMAN	STT3B	physical	26638075
SURF4_HUMAN	SURF4	physical	26638075
TAP2_HUMAN	TAP2	physical	26638075
TBL2_HUMAN	TBL2	physical	26638075
TECR_HUMAN	TECR	physical	26638075
TX264_HUMAN	TEX264	physical	26638075
TLCD1_HUMAN	TLCD1	physical	26638075
TLCD2_HUMAN	TLCD2	physical	26638075
TMCO1_HUMAN	TMCO1	physical	26638075
TM109_HUMAN	TMEM109	physical	26638075
EMC3_HUMAN	EMC3	physical	26638075
T120B_HUMAN	TMEM120B	physical	26638075
T161A_HUMAN	TMEM161A	physical	26638075
TM199_HUMAN	TMEM199	physical	26638075
TM209_HUMAN	TMEM209	physical	26638075
TM214_HUMAN	TMEM214	physical	26638075
TM222_HUMAN	TMEM222	physical	26638075
TM38B_HUMAN	TMEM38B	physical	26638075
TMM43_HUMAN	TMEM43	physical	26638075
NDC1_HUMAN	NDC1	physical	26638075
EMC4_HUMAN	EMC4	physical	26638075
EMC6_HUMAN	EMC6	physical	26638075
LAP2A_HUMAN	TMPO	physical	26638075
LAP2B_HUMAN	TMPO	physical	26638075
TMX1_HUMAN	TMX1	physical	26638075
TMX3_HUMAN	TMX3	physical	26638075
TOIP1_HUMAN	TOR1AIP1	physical	26638075
EMC2_HUMAN	EMC2	physical	26638075
UB2J1_HUMAN	UBE2J1	physical	26638075
UBXN4_HUMAN	UBXN4	physical	26638075
VAMP2_HUMAN	VAMP2	physical	26638075
VAMP3_HUMAN	VAMP3	physical	26638075
VAPA_HUMAN	VAPA	physical	26638075
VAPB_HUMAN	VAPB	physical	26638075
VEZA_HUMAN	VEZT	physical	26638075
VKORL_HUMAN	VKORC1L1	physical	26638075
VMA21_HUMAN	VMA21	physical	26638075
VMP1_HUMAN	VMP1	physical	26638075
VRK2_HUMAN	VRK2	physical	26638075
WDR41_HUMAN	WDR41	physical	26638075
WLS_HUMAN	WLS	physical	26638075
YKT6_HUMAN	YKT6	physical	26638075
FACE1_HUMAN	ZMPSTE24	physical	26638075
TM35B_HUMAN	ZMYM6NB	physical	26638075
AGK_HUMAN	AGK	physical	26638075
RUS1_HUMAN	C16orf58	physical	26638075
CR032_HUMAN	C18orf32	physical	26638075
CHMP7_HUMAN	CHMP7	physical	26638075
CNIH4_HUMAN	CNIH4	physical	26638075
DDX47_HUMAN	DDX47	physical	26638075
DHX30_HUMAN	DHX30	physical	26638075
JPH1_HUMAN	JPH1	physical	26638075
MBOA5_HUMAN	LPCAT3	physical	26638075
PLD3_HUMAN	PLD3	physical	26638075
PTN2_HUMAN	PTPN2	physical	26638075
ACOD_HUMAN	SCD	physical	26638075
SCD5_HUMAN	SCD5	physical	26638075
STX5_HUMAN	STX5	physical	26638075
P5I11_HUMAN	TP53I11	physical	26638075
TRI13_HUMAN	TRIM13	physical	26638075
HACD3_HUMAN	PTPLAD1	physical	26638075
HACD2_HUMAN	PTPLB	physical	26638075
PIGB_HUMAN	PIGB	physical	28514442
ALG12_HUMAN	ALG12	physical	28514442
GLRB_HUMAN	GLRB	physical	28514442
JMJD8_HUMAN	JMJD8	physical	28514442
NXPE3_HUMAN	NXPE3	physical	28514442
TMM8A_HUMAN	TMEM8A	physical	28514442
DMB_HUMAN	HLA-DMB	physical	28514442
GRID1_HUMAN	GRID1	physical	28514442
JAG2_HUMAN	JAG2	physical	28514442
EPHB4_HUMAN	EPHB4	physical	28514442
DCBD2_HUMAN	DCBLD2	physical	28514442
DYR2_HUMAN	DHFRL1	physical	28514442
B4GN1_HUMAN	B4GALNT1	physical	28514442
GALT7_HUMAN	GALNT7	physical	28514442
LRP12_HUMAN	LRP12	physical	28514442
DAG1_HUMAN	DAG1	physical	28514442
POMT2_HUMAN	POMT2	physical	28514442
ALG9_HUMAN	ALG9	physical	28514442
CNNM1_HUMAN	CNNM1	physical	28514442
LMF2_HUMAN	LMF2	physical	28514442
IMPA3_HUMAN	IMPAD1	physical	28514442
SLMAP_HUMAN	SLMAP	physical	28514442
TPST2_HUMAN	TPST2	physical	28514442
ATS2_HUMAN	ADAMTS2	physical	28514442
S47A1_HUMAN	SLC47A1	physical	28514442
PLXA2_HUMAN	PLXNA2	physical	28514442
GAS6_HUMAN	GAS6	physical	28514442
BACE2_HUMAN	BACE2	physical	28514442
ABCA3_HUMAN	ABCA3	physical	28514442
DNJA4_HUMAN	DNAJA4	physical	28514442
PGAP1_HUMAN	PGAP1	physical	28514442
ENTP7_HUMAN	ENTPD7	physical	28514442
GLBL2_HUMAN	GLB1L2	physical	28514442
NGBR_HUMAN	NUS1	physical	28514442
PIGQ_HUMAN	PIGQ	physical	28514442
KCNJ8_HUMAN	KCNJ8	physical	28514442
WNT5A_HUMAN	WNT5A	physical	28514442
IPRI_HUMAN	ITPRIP	physical	28514442
CGAT2_HUMAN	CSGALNACT2	physical	28514442
MKS3_HUMAN	TMEM67	physical	28514442
B4GT1_HUMAN	B4GALT1	physical	28514442
SL9A1_HUMAN	SLC9A1	physical	28514442
TM219_HUMAN	TMEM219	physical	28514442
HYAL2_HUMAN	HYAL2	physical	28514442
PTN1_HUMAN	PTPN1	physical	28514442
POMT1_HUMAN	POMT1	physical	28514442
D19L1_HUMAN	DPY19L1	physical	28514442
GLT12_HUMAN	GALNT12	physical	28514442
ITAV_HUMAN	ITGAV	physical	28514442
ABHEA_HUMAN	ABHD14A	physical	28514442
CQ080_HUMAN	C17orf80	physical	28514442
1B07_HUMAN	HLA-B	physical	28514442
1B18_HUMAN	HLA-B	physical	28514442
SGCB_HUMAN	SGCB	physical	28514442
MTCH1_HUMAN	MTCH1	physical	28514442
PROS_HUMAN	PROS1	physical	28514442
1A02_HUMAN	HLA-A	physical	28514442
1A03_HUMAN	HLA-A	physical	28514442
1A01_HUMAN	HLA-A	physical	28514442
1A26_HUMAN	HLA-A	physical	28514442
TM39A_HUMAN	TMEM39A	physical	28514442
LARG2_HUMAN	GYLTL1B	physical	28514442
CSTN3_HUMAN	CLSTN3	physical	28514442
FA69B_HUMAN	FAM69B	physical	28514442
SPCS2_HUMAN	SPCS2	physical	28514442
HMR1_HUMAN	MR1	physical	28514442
MGAT1_HUMAN	MGAT1	physical	28514442
TECT1_HUMAN	TCTN1	physical	27173435
TECT3_HUMAN	TCTN3	physical	27173435
STT3B_HUMAN	STT3B	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
613885	Meckel syndrome 8 (MKS8)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TECT2_HUMAN

Related Literatures of Post-Translational Modification