dbPTM

ANO10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ANO10_HUMAN
UniProt AC	Q9NW15
Protein Name	Anoctamin-10
Gene Name	ANO10
Organism	Homo sapiens (Human).
Sequence Length	660
Subcellular Localization	Cell membrane Multi-pass membrane protein . Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Protein Description	Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1..
Protein Sequence	MKVTLSALDTSESSFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLNKYEQETLENQNLYLVGASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAECQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPLHDSEALKKLEDTWYTRFALKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAVIGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMKRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNRLYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKDMKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKADIDATLYEQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNAVFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESLEALKQQQMKLVTENLKEEPMESGKEKAT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MKVTLSALDTSES --CCEEECCCCCCCC	19.88	28348404
13	Phosphorylation	SALDTSESSFTPLVV CCCCCCCCCCCCEEE	30.44	26657352
44	Malonylation	NRIIAKKKDGGAQLL HCHHEECCCCCCHHH	61.98	26320211
58 (in isoform 2)	Ubiquitination	-	50.57	-
58	Ubiquitination	LFRPLLNKYEQETLE HHHHHCHHHHHHHHC	50.57	-
82 (in isoform 4)	Ubiquitination	-	19.87	21890473
127 (in isoform 3)	Ubiquitination	-	1.37	21890473
127	Ubiquitination	TMAECQFIIKHELEN HHHHHHHHHHHHHHH	1.37	21890473
127	Ubiquitination	TMAECQFIIKHELEN HHHHHHHHHHHHHHH	1.37	21890473
141	Malonylation	NLRAKDEKMIPGYPQ HCHHCCCCCCCCCCC	52.87	32601280
155	Malonylation	QAKLYPGKSLLRRLL CHHCCCCHHHHHHHH	33.17	26320211
156	Phosphorylation	AKLYPGKSLLRRLLT HHCCCCHHHHHHHHH	38.25	24719451
163	Phosphorylation	SLLRRLLTSGIVIQV HHHHHHHHCCCEEEE	29.51	110759231
181	Ubiquitination	HDSEALKKLEDTWYT CCHHHHHHHHHCCCC	58.94	-
193	Ubiquitination	WYTRFALKYQPIDSI CCCEEEEECCCCCHH	38.11	21890473
193	Ubiquitination	WYTRFALKYQPIDSI CCCEEEEECCCCCHH	38.11	21890473
193 (in isoform 1)	Ubiquitination	-	38.11	21890473
193	Ubiquitination	WYTRFALKYQPIDSI CCCEEEEECCCCCHH	38.11	21890473
432	Phosphorylation	DMKLLRQSLATLLIT HHHHHHHHHHHHHHH	17.34	24043423
435	Phosphorylation	LLRQSLATLLITSQI HHHHHHHHHHHHHHH	27.65	24043423
439	Phosphorylation	SLATLLITSQILNQI HHHHHHHHHHHHHHH	17.97	24043423
440	Phosphorylation	LATLLITSQILNQIM HHHHHHHHHHHHHHH	14.29	24043423
449	Phosphorylation	ILNQIMESFLPYWLQ HHHHHHHHHHHHHHH	18.07	24043423
453	Phosphorylation	IMESFLPYWLQRKHG HHHHHHHHHHHHHHC	22.39	24043423
546	Phosphorylation	RVFKRPFSEPSANIG HHHCCCCCCCCCCCC	51.81	22210691
549	Phosphorylation	KRPFSEPSANIGVWQ CCCCCCCCCCCCHHH	29.87	22210691
587	Phosphorylation	VNAVFPESKADLILI CCCCCCCCCCCCHHH	33.12	22210691
636 (in isoform 1)	Ubiquitination	-	53.78	21890473
636	Ubiquitination	FESLEALKQQQMKLV HHHHHHHHHHHHHHH	53.78	21906983
641	Malonylation	ALKQQQMKLVTENLK HHHHHHHHHHHHCHH	35.15	26320211
648	Malonylation	KLVTENLKEEPMESG HHHHHCHHHCCCCCC	72.16	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ANO10_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ANO10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ANO10_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ANO10_HUMAN !!

Drug and Disease Associations

Kegg Disease
H00063	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
OMIM Disease
613728	Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ANO10_HUMAN

Related Literatures of Post-Translational Modification