SPCS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPCS1_HUMAN
• UniProt AC: Q9Y6A9
• Protein Name: Signal peptidase complex subunit 1
• Gene Name: SPCS1
• Organism: Homo sapiens (Human).
• Sequence Length: 102
• Subcellular Localization: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum..
• Protein Sequence: MLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYVAEQFGWTVYIVMAGFAFSCLLTLPPWPIYRRHPLKWLPVQESSTDDKKPGERKIKRHAKNN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	SLPTQMDYKGQKLAE CCCCCCCHHCHHHHH	50.33	-
15	Acetylation	LPTQMDYKGQKLAEQ CCCCCCHHCHHHHHH	33.65	26051181
15	Ubiquitination	LPTQMDYKGQKLAEQ CCCCCCHHCHHHHHH	33.65	-
18	Ubiquitination	QMDYKGQKLAEQMFQ CCCHHCHHHHHHHHH	28.82	-
76	Ubiquitination	IYRRHPLKWLPVQES CCCCCCCCCCCCCCC	23.64	-
82	Ubiquitination	LKWLPVQESSTDDKK CCCCCCCCCCCCCCC	51.07	21890473
83	Phosphorylation	KWLPVQESSTDDKKP CCCCCCCCCCCCCCC	24.51	30266825
84	Phosphorylation	WLPVQESSTDDKKPG CCCCCCCCCCCCCCC	33.18	30266825
85	Ubiquitination	LPVQESSTDDKKPGE CCCCCCCCCCCCCCH	59.33	22817900
85	Phosphorylation	LPVQESSTDDKKPGE CCCCCCCCCCCCCCH	59.33	30266825
88	2-Hydroxyisobutyrylation	QESSTDDKKPGERKI CCCCCCCCCCCHHHH	53.68	-
88	Malonylation	QESSTDDKKPGERKI CCCCCCCCCCCHHHH	53.68	26320211
89	Ubiquitination	ESSTDDKKPGERKIK CCCCCCCCCCHHHHH	32.17	-
89	Acetylation	ESSTDDKKPGERKIK CCCCCCCCCCHHHHH	32.17	25953088
89	Malonylation	ESSTDDKKPGERKIK CCCCCCCCCCHHHHH	32.17	26320211
94	Acetylation	DKKPGERKIKRHAKN CCCCCHHHHHHHHHC	1.39	7290171
100	Acetylation	RKIKRHAKNN----- HHHHHHHHCC-----	2.78	7290181
143	Ubiquitination	------------------------------------------------ ------------------------------------------------	51.65	23000965
150	Phosphorylation	------------------------------------------------------- -------------------------------------------------------	22.80	24719451
151	Phosphorylation	-------------------------------------------------------- --------------------------------------------------------	34.79	27251275
155	Malonylation	------------------------------------------------------------ ------------------------------------------------------------	64.77	26320211
156	Malonylation	------------------------------------------------------------- -------------------------------------------------------------	66.31	26320211
156	Ubiquitination	------------------------------------------------------------- -------------------------------------------------------------	66.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPCS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPCS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPCS1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SPCS1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.