TMX3_HUMAN - dbPTM
TMX3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TMX3_HUMAN
UniProt AC Q96JJ7
Protein Name Protein disulfide-isomerase TMX3
Gene Name TMX3
Organism Homo sapiens (Human).
Sequence Length 454
Subcellular Localization Endoplasmic reticulum membrane
Single-pass membrane protein .
Protein Description Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase..
Protein Sequence MAAWKSWTALRLCATVVVLDMVVCKGFVEDLDESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVARDYRDLFHRDFQFGHMDGNDYINTLLMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIVFDAKSTIVSIFKSSPLMGCFLFGLPLGVISIMCYGIYTADTDGGYIEERYEVSKSENENQEQIEESKEQQEPSSGGSVVPTVQEPKDVLEKKKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationTALRLCATVVVLDMV
HHHHHHHHHHHHHHH		16.9128387310
58UbiquitinationPWCGHCKKLEPIWNE
CCCCCCCCCCCCHHH		64.57-
71UbiquitinationNEVGLEMKSIGSPVK
HHHCCEEECCCCCEE		29.55-
78UbiquitinationKSIGSPVKVGKMDAT
ECCCCCEEECCCCCC		48.9621906983
78 (in isoform 2)Ubiquitination-48.9621906983
78 (in isoform 1)Ubiquitination-48.9621906983
81UbiquitinationGSPVKVGKMDATSYS
CCCEEECCCCCCCHH		36.2722817900
106UbiquitinationYPTIKLLKGDLAYNY
CCEEEEEECCCCCCC		61.90-
111PhosphorylationLLKGDLAYNYRGPRT
EEECCCCCCCCCCCC		21.74-
119UbiquitinationNYRGPRTKDDIIEFA
CCCCCCCHHHHHHHH		55.4724816145
126UbiquitinationKDDIIEFAHRVSGAL
HHHHHHHHHHHCCCC		4.1024816145
1482-HydroxyisobutyrylationQMFEHMQKRHRVFFV
HHHHHHHHHCCEEEE		42.47-
161PhosphorylationFVYVGGESPLKEKYI
EEEECCCCCCHHHHH		38.5224719451
166UbiquitinationGESPLKEKYIDAASE
CCCCCHHHHHHHHHH		46.01-
223UbiquitinationDGDLSSWINRERFQN
CCCHHHHHCHHHHHH		3.6322817900
258N-linked_GlycosylationLAVIDEKNTSVEHTR
EEEECCCCCCCCHHH		35.2219159218
2672-HydroxyisobutyrylationSVEHTRLKSIIQEVA
CCCHHHHHHHHHHHH		36.00-
267UbiquitinationSVEHTRLKSIIQEVA
CCCHHHHHHHHHHHH		36.0024816145
268PhosphorylationVEHTRLKSIIQEVAR
CCHHHHHHHHHHHHH		29.5222817900
273UbiquitinationLKSIIQEVARDYRDL
HHHHHHHHHHHHHHH		2.8021963094
313N-linked_GlycosylationVPTVVVLNTSNQQYF
CCEEEEEECCCCEEE		29.83UniProtKB CARBOHYD
364UbiquitinationKRIVFDAKSTIVSIF
HHHHHCCCCHHHHHH		50.4022817900
364 (in isoform 1)Ubiquitination-50.4021906983
369PhosphorylationDAKSTIVSIFKSSPL
CCCCHHHHHHCCCCC		20.6124719451
387UbiquitinationFLFGLPLGVISIMCY
HHHCCCHHHHHHHHE		16.8733845483
393S-palmitoylationLGVISIMCYGIYTAD
HHHHHHHHEEEEECC		2.4129575903
410PhosphorylationGGYIEERYEVSKSEN
CCCEEEEEEECCCCC		24.7828796482
413PhosphorylationIEERYEVSKSENENQ
EEEEEEECCCCCCCH		20.6529507054
414 (in isoform 1)Ubiquitination-67.9521906983
414UbiquitinationEERYEVSKSENENQE
EEEEEECCCCCCCHH		67.9521963094
415PhosphorylationERYEVSKSENENQEQ
EEEEECCCCCCCHHH		37.8430576142
426PhosphorylationNQEQIEESKEQQEPS
CHHHHHHHHHHCCCC		28.8020639409
433PhosphorylationSKEQQEPSSGGSVVP
HHHHCCCCCCCCCCC		40.6428355574
434PhosphorylationKEQQEPSSGGSVVPT
HHHCCCCCCCCCCCC		58.8721815630
437PhosphorylationQEPSSGGSVVPTVQE
CCCCCCCCCCCCCCC		24.3825850435
441PhosphorylationSGGSVVPTVQEPKDV
CCCCCCCCCCCCHHH		24.1820639409
446UbiquitinationVPTVQEPKDVLEKKK
CCCCCCCHHHHHHCC		60.7729967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TMX3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TMX3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TMX3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TMX3_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-258, AND MASSSPECTROMETRY.
Phosphorylation
ReferencePubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, AND MASSSPECTROMETRY.

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