VEZA_HUMAN - dbPTM
VEZA_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VEZA_HUMAN
UniProt AC Q9HBM0
Protein Name Vezatin
Gene Name VEZT
Organism Homo sapiens (Human).
Sequence Length 779
Subcellular Localization Cell membrane
Multi-pass membrane protein. Cell junction, adherens junction. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome.
Protein Description Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in myosin VIIa recruitment to the entry site..
Protein Sequence MTPEFDEEVVFENSPLYQYLQDLGHTDFEICSSLSPKTEKCTTEGQQKPPTRVLPKQGILLKVAETIKSWIFFSQCNKKDDLLHKLDIGFRLDSLHTILQQEVLLQEDVELIELLDPSILSAGQSQQQENGHLPTLCSLATPNIWDLSMLFAFISLLVMLPTWWIVSSWLVWGVILFVYLVIRALRLWRTAKLQVTLKKYSVHLEDMATNSRAFTNLVRKALRLIQETEVISRGFTLVSAACPFNKAGQHPSQHLIGLRKAVYRTLRANFQAARLATLYMLKNYPLNSESDNVTNYICVVPFKELGLGLSEEQISEEEAHNFTDGFSLPALKVLFQLWVAQSSEFFRRLALLLSTANSPPGPLLTPALLPHRILSDVTQGLPHAHSACLEELKRSYEFYRYFETQHQSVPQCLSKTQQKSRELNNVHTAVRSLQLHLKALLNEVIILEDELEKLVCTKETQELVSEAYPILEQKLKLIQPHVQASNNCWEEAISQVDKLLRRNTDKKGKPEIACENPHCTVVPLKQPTLHIADKDPIPEEQELEAYVDDIDIDSDFRKDDFYYLSQEDKERQKREHEESKRVLQELKSVLGFKASEAERQKWKQLLFSDHAVLKSLSPVDPVEPISNSEPSMNSDMGKVSKNDTEEESNKSATTDNEISRTEYLCENSLEGKNKDNSSNEVFPQGAEERMCYQCESEDEPQADGSGLTTAPPTPRDSLQPSIKQRLARLQLSPDFTFTAGLAAEVAARSLSFTTMQEQTFGGEEEEQIIEENKNEIEEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
33PhosphorylationTDFEICSSLSPKTEK
CCHHHHHCCCCCCCC		28.5824719451
35PhosphorylationFEICSSLSPKTEKCT
HHHHHCCCCCCCCCC		26.7124719451
40UbiquitinationSLSPKTEKCTTEGQQ
CCCCCCCCCCCCCCC		41.9529967540
56UbiquitinationPPTRVLPKQGILLKV
CCCCCCCCCCCHHHH		57.9329967540
62AcetylationPKQGILLKVAETIKS
CCCCCHHHHHHHHHH		35.6370907
68UbiquitinationLKVAETIKSWIFFSQ
HHHHHHHHHHHHHHH		47.3533845483
69PhosphorylationKVAETIKSWIFFSQC
HHHHHHHHHHHHHHC		22.8929255136
74PhosphorylationIKSWIFFSQCNKKDD
HHHHHHHHHCCCCCH		24.0729255136
200PhosphorylationLQVTLKKYSVHLEDM
HEEEEEEEEEEHHHH		17.8425262027
201PhosphorylationQVTLKKYSVHLEDMA
EEEEEEEEEEHHHHH		16.3725262027
209PhosphorylationVHLEDMATNSRAFTN
EEHHHHHCCCHHHHH		27.3925262027
228PhosphorylationALRLIQETEVISRGF
HHHHHHHHCHHHCCE		21.12-
232PhosphorylationIQETEVISRGFTLVS
HHHHCHHHCCEEEEE		31.37-
267UbiquitinationKAVYRTLRANFQAAR
HHHHHHHHHHHHHHH		27.2021963094
271UbiquitinationRTLRANFQAARLATL
HHHHHHHHHHHHHHH		33.6421963094
322UbiquitinationSEEEAHNFTDGFSLP
CHHHHHCCCCCCCHH		4.7721963094
326UbiquitinationAHNFTDGFSLPALKV
HHCCCCCCCHHHHHH		8.2521963094
337UbiquitinationALKVLFQLWVAQSSE
HHHHHHHHHHHCCHH		2.8821963094
341UbiquitinationLFQLWVAQSSEFFRR
HHHHHHHCCHHHHHH		37.5621963094
367UbiquitinationPGPLLTPALLPHRIL
CCCCCCHHHCCHHHH		19.2521963094
371UbiquitinationLTPALLPHRILSDVT
CCHHHCCHHHHHHHH		29.4021963094
375PhosphorylationLLPHRILSDVTQGLP
HCCHHHHHHHHCCCC		27.88-
378PhosphorylationHRILSDVTQGLPHAH
HHHHHHHHCCCCCHH		23.16-
379 (in isoform 5)Ubiquitination-51.8021906983
385UbiquitinationTQGLPHAHSACLEEL
HCCCCCHHHHHHHHH		16.9421963094
386PhosphorylationQGLPHAHSACLEELK
CCCCCHHHHHHHHHH		22.8128348404
389UbiquitinationPHAHSACLEELKRSY
CCHHHHHHHHHHHHH		5.9921963094
404UbiquitinationEFYRYFETQHQSVPQ
HHHHHHHHHCCCHHH		22.8121963094
408UbiquitinationYFETQHQSVPQCLSK
HHHHHCCCHHHHHHH		33.3721963094
415UbiquitinationSVPQCLSKTQQKSRE
CHHHHHHHHHHHHHH		37.0921963094
419UbiquitinationCLSKTQQKSRELNNV
HHHHHHHHHHHHCCH		41.4821963094
421UbiquitinationSKTQQKSRELNNVHT
HHHHHHHHHHCCHHH		60.5024816145
425UbiquitinationQKSRELNNVHTAVRS
HHHHHHCCHHHHHHH		39.3024816145
426 (in isoform 2)Ubiquitination-4.0621906983
426 (in isoform 6)Ubiquitination-4.0621906983
434UbiquitinationHTAVRSLQLHLKALL
HHHHHHHHHHHHHHH		28.2521963094
438UbiquitinationRSLQLHLKALLNEVI
HHHHHHHHHHHHCCC		26.6621963094
445UbiquitinationKALLNEVIILEDELE
HHHHHCCCCCHHHHH		2.1327667366
449UbiquitinationNEVIILEDELEKLVC
HCCCCCHHHHHHHHC		63.4427667366
458UbiquitinationLEKLVCTKETQELVS
HHHHHCCHHHHHHHH		54.3529967540
474UbiquitinationAYPILEQKLKLIQPH
HHHHHHHHHHHHHHH		37.9129967540
474 (in isoform 1)Ubiquitination-37.9121906983
476UbiquitinationPILEQKLKLIQPHVQ
HHHHHHHHHHHHHHH		51.0524816145
480UbiquitinationQKLKLIQPHVQASNN
HHHHHHHHHHHHCCC		23.7124816145
491UbiquitinationASNNCWEEAISQVDK
HCCCHHHHHHHHHHH		27.1424816145
495UbiquitinationCWEEAISQVDKLLRR
HHHHHHHHHHHHHHH		41.1224816145
500UbiquitinationISQVDKLLRRNTDKK
HHHHHHHHHHCCCCC		6.2727667366
504UbiquitinationDKLLRRNTDKKGKPE
HHHHHHCCCCCCCCC		47.5927667366
515UbiquitinationGKPEIACENPHCTVV
CCCCCCCCCCCCEEE		65.8527667366
519UbiquitinationIACENPHCTVVPLKQ
CCCCCCCCEEEECCC		3.0527667366
521UbiquitinationCENPHCTVVPLKQPT
CCCCCCEEEECCCCC		5.2024816145
525UbiquitinationHCTVVPLKQPTLHIA
CCEEEECCCCCEEEC		48.4324816145
539UbiquitinationADKDPIPEEQELEAY
CCCCCCCHHHHHHHH		73.3824816145
543UbiquitinationPIPEEQELEAYVDDI
CCCHHHHHHHHHCCC		4.5724816145
545UbiquitinationPEEQELEAYVDDIDI
CHHHHHHHHHCCCCC		23.4427667366
549UbiquitinationELEAYVDDIDIDSDF
HHHHHHCCCCCCCCC		30.3427667366
558UbiquitinationDIDSDFRKDDFYYLS
CCCCCCCCCCCEECC		62.7424816145
562PhosphorylationDFRKDDFYYLSQEDK
CCCCCCCEECCHHHH		15.5328796482
562UbiquitinationDFRKDDFYYLSQEDK
CCCCCCCEECCHHHH		15.5324816145
563PhosphorylationFRKDDFYYLSQEDKE
CCCCCCEECCHHHHH		10.4028796482
563UbiquitinationFRKDDFYYLSQEDKE
CCCCCCEECCHHHHH		10.4027667366
565PhosphorylationKDDFYYLSQEDKERQ
CCCCEECCHHHHHHH		18.5327642862
567UbiquitinationDFYYLSQEDKERQKR
CCEECCHHHHHHHHH		68.6127667366
569UbiquitinationYYLSQEDKERQKREH
EECCHHHHHHHHHHH		54.7824816145
573UbiquitinationQEDKERQKREHEESK
HHHHHHHHHHHHHHH		67.0124816145
582UbiquitinationEHEESKRVLQELKSV
HHHHHHHHHHHHHHH		8.1127667366
586UbiquitinationSKRVLQELKSVLGFK
HHHHHHHHHHHHCCC		3.0227667366
587UbiquitinationKRVLQELKSVLGFKA
HHHHHHHHHHHCCCC		37.4529967540
588UbiquitinationRVLQELKSVLGFKAS
HHHHHHHHHHCCCCC		34.8924816145
592UbiquitinationELKSVLGFKASEAER
HHHHHHCCCCCHHHH		5.3724816145
593MethylationLKSVLGFKASEAERQ
HHHHHCCCCCHHHHH		49.56115978809
593UbiquitinationLKSVLGFKASEAERQ
HHHHHCCCCCHHHHH		49.5633845483
597UbiquitinationLGFKASEAERQKWKQ
HCCCCCHHHHHHHHH		18.1227667366
601UbiquitinationASEAERQKWKQLLFS
CCHHHHHHHHHHHHC		63.6829967540
612UbiquitinationLLFSDHAVLKSLSPV
HHHCCHHHHHCCCCC		6.5827667366
615PhosphorylationSDHAVLKSLSPVDPV
CCHHHHHCCCCCCCC		29.8922199227
616UbiquitinationDHAVLKSLSPVDPVE
CHHHHHCCCCCCCCC		6.8427667366
617PhosphorylationHAVLKSLSPVDPVEP
HHHHHCCCCCCCCCC		29.9321815630
626PhosphorylationVDPVEPISNSEPSMN
CCCCCCCCCCCCCCC		45.0528102081
628PhosphorylationPVEPISNSEPSMNSD
CCCCCCCCCCCCCCC		44.0628102081
631PhosphorylationPISNSEPSMNSDMGK
CCCCCCCCCCCCCCC		26.9228102081
644PhosphorylationGKVSKNDTEEESNKS
CCCCCCCCHHHHHCC		55.4823663014
648PhosphorylationKNDTEEESNKSATTD
CCCCHHHHHCCCCCC		53.4923663014
651PhosphorylationTEEESNKSATTDNEI
CHHHHHCCCCCCCHH		34.7923663014
653PhosphorylationEESNKSATTDNEISR
HHHHCCCCCCCHHHH		41.6023663014
654PhosphorylationESNKSATTDNEISRT
HHHCCCCCCCHHHHH		36.2222199227
659PhosphorylationATTDNEISRTEYLCE
CCCCCHHHHHHHHHH		27.2921815630
661PhosphorylationTDNEISRTEYLCENS
CCCHHHHHHHHHHHC		23.3822199227
663PhosphorylationNEISRTEYLCENSLE
CHHHHHHHHHHHCCC		18.9528796482
668PhosphorylationTEYLCENSLEGKNKD
HHHHHHHCCCCCCCC		12.9021815630
672UbiquitinationCENSLEGKNKDNSSN
HHHCCCCCCCCCCCC		51.9929967540
677PhosphorylationEGKNKDNSSNEVFPQ
CCCCCCCCCCCCCCC		44.6821815630
678PhosphorylationGKNKDNSSNEVFPQG
CCCCCCCCCCCCCCC		43.1721815630
692PhosphorylationGAEERMCYQCESEDE
CHHHHEEEECCCCCC		13.5730108239
696PhosphorylationRMCYQCESEDEPQAD
HEEEECCCCCCCCCC		58.9630278072
705PhosphorylationDEPQADGSGLTTAPP
CCCCCCCCCCCCCCC		31.0430108239
708PhosphorylationQADGSGLTTAPPTPR
CCCCCCCCCCCCCCH		25.1629978859
709PhosphorylationADGSGLTTAPPTPRD
CCCCCCCCCCCCCHH		42.0628111955
713PhosphorylationGLTTAPPTPRDSLQP
CCCCCCCCCHHHCCH		29.8726657352
721PhosphorylationPRDSLQPSIKQRLAR
CHHHCCHHHHHHHHH		29.47-
723UbiquitinationDSLQPSIKQRLARLQ
HHCCHHHHHHHHHCC		33.4329967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VEZA_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VEZA_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VEZA_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CTNA1_HUMANCTNNA1physical
11080149
CTNB1_HUMANCTNNB1physical
11080149
CADH1_HUMANCDH1physical
11080149
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VEZA_HUMAN

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Related Literatures of Post-Translational Modification

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