B4GN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: B4GN1_HUMAN
• UniProt AC: Q00973
• Protein Name: Beta-1,4 N-acetylgalactosaminyltransferase 1
• Gene Name: B4GALNT1
• Organism: Homo sapiens (Human).
• Sequence Length: 533
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Involved in the biosynthesis of gangliosides GM2, GD2 and GA2..
• Protein Sequence: MWLGRRALCALVLLLACASLGLLYASTRDAPGLRLPLAPWAPPQSPRRPELPDLAPEPRYAHIPVRIKEQVVGLLAWNNCSCESSGGGLPLPFQKQVRAIDLTKAFDPAELRAASATREQEFQAFLSRSQSPADQLLIAPANSPLQYPLQGVEVQPLRSILVPGLSLQAASGQEVYQVNLTASLGTWDVAGEVTGVTLTGEGQADLTLVSPGLDQLNRQLQLVTYSSRSYQTNTADTVRFSTEGHEAAFTIRIRHPPNPRLYPPGSLPQGAQYNISALVTIATKTFLRYDRLRALITSIRRFYPTVTVVIADDSDKPERVSGPYVEHYLMPFGKGWFAGRNLAVSQVTTKYVLWVDDDFVFTARTRLERLVDVLERTPLDLVGGAVREISGFATTYRQLLSVEPGAPGLGNCLRQRRGFHHELVGFPGCVVTDGVVNFFLARTDKVREVGFDPRLSRVAHLEFFLDGLGSLRVGSCSDVVVDHASKLKLPWTSRDAGAETYARYRYPGSLDESQMAKHRLLFFKHRLQCMTSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	N-linked_Glycosylation	VGLLAWNNCSCESSG HEEEEECCCCCCCCC	14.37	UniProtKB CARBOHYD
104	Ubiquitination	VRAIDLTKAFDPAEL EEEEECCCCCCHHHH	55.12	21906983
104	Ubiquitination	VRAIDLTKAFDPAEL EEEEECCCCCCHHHH	55.12	21906983
179	N-linked_Glycosylation	GQEVYQVNLTASLGT CCEEEEEEEEEEECC	19.02	UniProtKB CARBOHYD
224	Phosphorylation	NRQLQLVTYSSRSYQ HHHHEEEEECCCCCC	26.69	30576142
250	Phosphorylation	EGHEAAFTIRIRHPP CCCEEEEEEEECCCC	12.48	24719451
274	N-linked_Glycosylation	LPQGAQYNISALVTI CCCCCCCCHHHHHHH	15.06	UniProtKB CARBOHYD
297	Phosphorylation	DRLRALITSIRRFYP HHHHHHHHHHHHHCC	20.96	22468782
298	Phosphorylation	RLRALITSIRRFYPT HHHHHHHHHHHHCCE	13.70	22468782
303	Phosphorylation	ITSIRRFYPTVTVVI HHHHHHHCCEEEEEE	9.00	25907765
305	Phosphorylation	SIRRFYPTVTVVIAD HHHHHCCEEEEEEEC	19.89	25907765
307	Phosphorylation	RRFYPTVTVVIADDS HHHCCEEEEEEECCC	16.13	25907765
314	Phosphorylation	TVVIADDSDKPERVS EEEEECCCCCCCCCC	48.35	25907765
377	Phosphorylation	LVDVLERTPLDLVGG HHHHHHHCCHHHHHH	20.87	-
470	Phosphorylation	FFLDGLGSLRVGSCS HHHHCCCCCCCCCCC	20.32	24719451
501	Phosphorylation	RDAGAETYARYRYPG CCCCCCEEEECCCCC	4.79	-
517	"N6,N6-dimethyllysine"	LDESQMAKHRLLFFK CCHHHHHHHHHHHHH	24.74	-
517	Methylation	LDESQMAKHRLLFFK CCHHHHHHHHHHHHH	24.74	-
524	"N6,N6-dimethyllysine"	KHRLLFFKHRLQCMT HHHHHHHHHHHHHHC	22.08	-
524	Methylation	KHRLLFFKHRLQCMT HHHHHHHHHHHHHHC	22.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of B4GN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of B4GN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of B4GN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
B4GN1_HUMAN	B4GALNT1	physical	11018043

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 609195: Spastic paraplegia 26, autosomal recessive (SPG26)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.