ALG9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALG9_HUMAN
• UniProt AC: Q9H6U8
• Protein Name: Alpha-1,2-mannosyltransferase ALG9 {ECO:0000305}
• Gene Name: ALG9 {ECO:0000312|HGNC:HGNC:15672}
• Organism: Homo sapiens (Human).
• Sequence Length: 611
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides..
• Protein Sequence: MASRGARQRLKGSGASSGDTAPAADKLRELLGSREAGGAEHRTELSGNKAGQVWAPEGSTAFKCLLSARLCAALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPAAFHARILQTNKILVFYFLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYMDKTSIAVLGVAAGAILGWPFSAALGLPIAFDLLVMKHRWKSFFHWSLMALILFLVPVVVIDSYYYGKLVIAPLNIVLYNVFTPHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLTLAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQKCYHFVFQRYRLEHYTVTSNWLALGTVFLFGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKEWYRFPSSFLLPDNWQLQFIPSEFRGQLPKPFAEGPLATRIVPTDMNDQNLEEPSRYIDISKCHYLVDLDTMRETPREPKYSSNKEEWISLAYRPFLDASRSSKLLRAFYVPFLSDQYTVYVNYTILKPRKAKQIRKKSGG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Methylation	RGARQRLKGSGASSG HHHHHHHCCCCCCCC	53.90	-
13	Phosphorylation	ARQRLKGSGASSGDT HHHHHCCCCCCCCCC	29.60	26657352
16	Phosphorylation	RLKGSGASSGDTAPA HHCCCCCCCCCCCCH	38.08	29255136
17	Phosphorylation	LKGSGASSGDTAPAA HCCCCCCCCCCCCHH	39.90	22798277
26	2-Hydroxyisobutyrylation	DTAPAADKLRELLGS CCCCHHHHHHHHHCC	44.72	-
26 (in isoform 1)	Ubiquitination	-	44.72	21906983
26	Ubiquitination	DTAPAADKLRELLGS CCCCHHHHHHHHHCC	44.72	21906983
49 (in isoform 1)	Ubiquitination	-	58.37	21906983
49	Ubiquitination	RTELSGNKAGQVWAP CCCCCCCCCCCEECC	58.37	2190698
49 (in isoform 3)	Ubiquitination	-	58.37	-
63	Ubiquitination	PEGSTAFKCLLSARL CCCCHHHHHHHHHHH	22.85	-
63 (in isoform 3)	Ubiquitination	-	22.85	-
67	Phosphorylation	TAFKCLLSARLCAAL HHHHHHHHHHHHHHH	9.82	24719451
77	N-linked_Glycosylation	LCAALLSNISDCDET HHHHHHHCCCCCCHH	37.44	UniProtKB CARBOHYD
180	Phosphorylation	MLAFLVLSTGMFCSS HHHHHHHHCCCCCCC	18.55	24043423
181	Phosphorylation	LAFLVLSTGMFCSSS HHHHHHHCCCCCCCC	28.62	24043423
186	Phosphorylation	LSTGMFCSSSAFLPS HHCCCCCCCCCCCCH	18.96	24043423
187	Phosphorylation	STGMFCSSSAFLPSS HCCCCCCCCCCCCHH	27.20	24043423
188	Phosphorylation	TGMFCSSSAFLPSSF CCCCCCCCCCCCHHH	13.52	24043423
193	Phosphorylation	SSSAFLPSSFCMYTT CCCCCCCHHHHHHHH	37.89	24043423
194	Phosphorylation	SSAFLPSSFCMYTTL CCCCCCHHHHHHHHH	22.11	24043423
198	Phosphorylation	LPSSFCMYTTLIAMT CCHHHHHHHHHHHHH	9.58	24043423
199	Phosphorylation	PSSFCMYTTLIAMTG CHHHHHHHHHHHHHC	6.56	24043423
200	Phosphorylation	SSFCMYTTLIAMTGW HHHHHHHHHHHHHCC	9.93	24043423
205	Phosphorylation	YTTLIAMTGWYMDKT HHHHHHHHCCCCCHH	18.62	24043423
208	Phosphorylation	LIAMTGWYMDKTSIA HHHHHCCCCCHHHHH	9.22	24043423
259 (in isoform 3)	Ubiquitination	-	1.86	21906983
282 (in isoform 3)	Ubiquitination	-	5.16	21906983
343	Ubiquitination	QRFHVQNLGHPYWLT HHHCHHCCCCCHHHH	3.59	21963094
359	Ubiquitination	APMYIWFIIFFIQPH HHHHHHHHHHHCCCC	1.29	21963094
384	Ubiquitination	PLICLCGAVALSALQ HHHHHHHHHHHHHHH	5.17	21963094
391	Ubiquitination	AVALSALQKCYHFVF HHHHHHHHHHHHHHH	33.23	21963094
451	Phosphorylation	PEFYRIATDPTIHTV HHHHHHCCCCCCEEC	39.89	12302391
457	Phosphorylation	ATDPTIHTVPEGRPV CCCCCCEECCCCCCE	33.63	12302401
470	Ubiquitination	PVNVCVGKEWYRFPS CEEEEECCCEEECCC	25.36	-
477 (in isoform 3)	Ubiquitination	-	30.89	-
514	Ubiquitination	LATRIVPTDMNDQNL CCEEECCCCCCCCCC	36.67	21963094
521	Ubiquitination	TDMNDQNLEEPSRYI CCCCCCCCCCCHHEE	7.01	21963094
525	Phosphorylation	DQNLEEPSRYIDISK CCCCCCCHHEEEHHH	40.78	22210691
532	Ubiquitination	SRYIDISKCHYLVDL HHEEEHHHCCEEEEH	25.93	-
539 (in isoform 3)	Ubiquitination	-	4.62	-
551	Phosphorylation	ETPREPKYSSNKEEW CCCCCCCCCCCHHHH	28.22	28258704
555	Ubiquitination	EPKYSSNKEEWISLA CCCCCCCHHHHHHHH	59.98	21963094
562 (in isoform 3)	Ubiquitination	-	7.47	-
562	Ubiquitination	KEEWISLAYRPFLDA HHHHHHHHHHHHHCC	7.47	21963094
593	N-linked_Glycosylation	DQYTVYVNYTILKPR CCEEEEEEEEEECCH	15.56	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALG9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALG9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALG9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BHMT1_HUMAN	BHMT	physical	21988832
COR1C_HUMAN	CORO1C	physical	26344197
HNRPF_HUMAN	HNRNPF	physical	26344197

Drug and Disease Associations

• Kegg Disease
• H00118: Congenital disorders of glycosylation (CDG) type I
• OMIM Disease
• : Note=A chromosomal aberration involving ALG9 is found in a family with bipolar affective disorder. Translocation t(9
• : 11)(p24
• : q23). However, common variations in ALG9 do not play a major role in predisposition to bipolar affective disorder.
• 608776:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.