BHMT1_HUMAN - dbPTM
BHMT1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BHMT1_HUMAN
UniProt AC Q93088
Protein Name Betaine--homocysteine S-methyltransferase 1
Gene Name BHMT
Organism Homo sapiens (Human).
Sequence Length 406
Subcellular Localization Cytoplasm.
Protein Description Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline..
Protein Sequence MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
40SuccinylationLEKRGYVKAGPWTPE
EEECCCEECCCCCHH		38.86-
40SuccinylationLEKRGYVKAGPWTPE
EEECCCEECCCCCHH		38.86-
45PhosphorylationYVKAGPWTPEAAVEH
CEECCCCCHHHHHHC		17.8728857561
73PhosphorylationAGSNVMQTFTFYASE
CCCCEEEEEEEEECH		13.4228857561
75PhosphorylationSNVMQTFTFYASEDK
CCEEEEEEEEECHHH		21.0828857561
77PhosphorylationVMQTFTFYASEDKLE
EEEEEEEEECHHHHH		13.2228857561
79PhosphorylationQTFTFYASEDKLENR
EEEEEEECHHHHHHC		34.6428857561
93SuccinylationRGNYVLEKISGQEVN
CCCEEEEECCCCHHH		37.70-
93SuccinylationRGNYVLEKISGQEVN
CCCEEEEECCCCHHH		37.70-
130PhosphorylationSQTPSYLSCKSETEV
CCCCCCCCCCCHHHH		15.9728857561
133PhosphorylationPSYLSCKSETEVKKV
CCCCCCCCHHHHHHH		54.8228857561
135PhosphorylationYLSCKSETEVKKVFL
CCCCCCHHHHHHHHH		53.8428857561
232SuccinylationLKTVKLMKEGLEAAR
HHHHHHHHHHHHHHH		60.09-
232SuccinylationLKTVKLMKEGLEAAR
HHHHHHHHHHHHHHH		60.09-
241SuccinylationGLEAARLKAHLMSQP
HHHHHHHHHHHHHCC		28.36-
241SuccinylationGLEAARLKAHLMSQP
HHHHHHHHHHHHHCC		28.36-
277PhosphorylationGLEPRVATRWDIQKY
CCCCCCCCHHHHHHH		29.4524043423
289PhosphorylationQKYAREAYNLGVRYI
HHHHHHHHHCCCCCC		13.23-
305PhosphorylationGCCGFEPYHIRAIAE
CCCCCCHHHHHHHHH		11.59-
330PhosphorylationPASEKHGSWGSGLDM
CHHHCCCCCCCCCCC		28.1628192239
333PhosphorylationEKHGSWGSGLDMHTK
HCCCCCCCCCCCCCC		29.8925072903
340MethylationSGLDMHTKPWVRARA
CCCCCCCCHHHHHHH		23.39-
340SuccinylationSGLDMHTKPWVRARA
CCCCCCCCHHHHHHH		23.39-
340SuccinylationSGLDMHTKPWVRARA
CCCCCCCCHHHHHHH		23.39-
351PhosphorylationRARARKEYWENLRIA
HHHHHHHHHHHCEEC		22.5128102081
363PhosphorylationRIASGRPYNPSMSKP
EECCCCCCCCCCCCC		38.0421253578
366PhosphorylationSGRPYNPSMSKPDGW
CCCCCCCCCCCCCCC		31.86-
369AcetylationPYNPSMSKPDGWGVT
CCCCCCCCCCCCCCC		38.1920167786
377SuccinylationPDGWGVTKGTAELMQ
CCCCCCCHHHHHHHH		52.43-
377SuccinylationPDGWGVTKGTAELMQ
CCCCCCCHHHHHHHH		52.43-
379PhosphorylationGWGVTKGTAELMQQK
CCCCCHHHHHHHHHH		20.6522798277
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BHMT1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BHMT1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BHMT1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BHMT1_HUMANBHMTphysical
16189514
BHMT1_HUMANBHMTphysical
11223523
LTOR3_HUMANLAMTOR3physical
21988832
BHMT1_HUMANBHMTphysical
25416956
BHMT2_HUMANBHMT2physical
28514442
MTMR6_HUMANMTMR6physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00134L-Methionine
Regulatory Network of BHMT1_HUMAN

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Related Literatures of Post-Translational Modification

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