BHMT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BHMT2_HUMAN
• UniProt AC: Q9H2M3
• Protein Name: S-methylmethionine--homocysteine S-methyltransferase BHMT2
• Gene Name: BHMT2
• Organism: Homo sapiens (Human).
• Sequence Length: 363
• Protein Description: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor..
• Protein Sequence: MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLHMEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYKYQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGPEGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPLGFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSKPDF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Phosphorylation	MEFLRAGSNVMQTFT HHHHHCCCCEEEEEE	25.85	29978859
73	Phosphorylation	AGSNVMQTFTFSASE CCCCEEEEEEEECCC	13.42	29978859
75	Phosphorylation	SNVMQTFTFSASEDN CCEEEEEEEECCCCC	21.77	29978859
77	Phosphorylation	VMQTFTFSASEDNME EEEEEEEECCCCCHH	28.03	29978859
79	Phosphorylation	QTFTFSASEDNMESK EEEEEECCCCCHHHH	44.26	29978859
85	Phosphorylation	ASEDNMESKWEDVNA CCCCCHHHHHHHHHH	32.09	29978859
280	Phosphorylation	QKYAREAYNLGVRYI HHHHHHHHHCCCCCC	13.23	-
296	Phosphorylation	GCCGFEPYHIRAIAE CCCCCCHHHHHHHHH	11.59	-
321	Phosphorylation	PASEKHGSWGSGLDM CHHHCCCCCCCCCCC	28.16	28192239
324	Phosphorylation	EKHGSWGSGLDMHTK HCCCCCCCCCCCCCH	29.89	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BHMT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BHMT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BHMT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
BHMT1_HUMAN	BHMT	physical	26186194
SHIP2_HUMAN	INPPL1	physical	26186194
TBCE_HUMAN	TBCE	physical	26186194
TBCE_HUMAN	TBCE	physical	28514442
SHIP2_HUMAN	INPPL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.