MTMR6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTMR6_HUMAN
• UniProt AC: Q9Y217
• Protein Name: Myotubularin-related protein 6
• Gene Name: MTMR6
• Organism: Homo sapiens (Human).
• Sequence Length: 621
• Subcellular Localization: Nucleus envelope .
• Protein Description: Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells..
• Protein Sequence: MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQKETWILHHHIASVEKLALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDEHLLQAISKANPVNRYMYVMDTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESPNLKTSLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAEEFSKSEPAVVSLEYGVARMTC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MEHIRTTKVEQVKLL CCCCCCCCHHHEEEH	43.06	22817900
13	Ubiquitination	TTKVEQVKLLDRFST CCCHHHEEEHHHHCC	42.92	21906983
13 (in isoform 1)	Ubiquitination	-	42.92	21890473
13 (in isoform 2)	Ubiquitination	-	42.92	21890473
55	Phosphorylation	ILHHHIASVEKLALT EEEEECCCHHHHEEE	30.15	24719451
58	Ubiquitination	HHIASVEKLALTTSG EECCCHHHHEEECCC	36.58	22817900
88	Ubiquitination	IVPRERDCHDIYNSL ECCCCCCHHHHHHHH	3.78	27667366
94	Phosphorylation	DCHDIYNSLLQLSKQ CHHHHHHHHHHHHHH	17.31	20873877
96	Ubiquitination	HDIYNSLLQLSKQAK HHHHHHHHHHHHHCC	4.90	22817900
100	Ubiquitination	NSLLQLSKQAKYEDL HHHHHHHHHCCCCCE	63.97	29967540
103	Ubiquitination	LQLSKQAKYEDLYAF HHHHHHCCCCCEEEE	46.83	-
104	Phosphorylation	QLSKQAKYEDLYAFS HHHHHCCCCCEEEEE	20.07	29978859
108	Phosphorylation	QAKYEDLYAFSYNPK HCCCCCEEEEECCCC	20.23	29978859
111	Phosphorylation	YEDLYAFSYNPKQND CCCEEEEECCCCCCC	18.81	29978859
112	Phosphorylation	EDLYAFSYNPKQNDS CCEEEEECCCCCCCH	29.09	29978859
115	Ubiquitination	YAFSYNPKQNDSERL EEEECCCCCCCHHHH	59.08	21906983
115 (in isoform 1)	Ubiquitination	-	59.08	21890473
115 (in isoform 2)	Ubiquitination	-	59.08	21890473
117	Ubiquitination	FSYNPKQNDSERLQG EECCCCCCCHHHHCH	61.98	32015554
135	Acetylation	IDLAEEYKRMGVPNS HHHHHHHHHCCCCCC	38.91	24468315
135	Ubiquitination	IDLAEEYKRMGVPNS HHHHHHHHHCCCCCC	38.91	21906983
135 (in isoform 1)	Ubiquitination	-	38.91	21890473
135 (in isoform 2)	Ubiquitination	-	38.91	21890473
153	Phosphorylation	LSDANRDYKICETYP CCCCCCCCCCCCCCC	10.06	-
154	Ubiquitination	SDANRDYKICETYPR CCCCCCCCCCCCCCC	45.21	27667366
170	Phosphorylation	LYVPRIASKPIIVGS CCCCCCCCCCEEEEC	36.27	-
171	Ubiquitination	YVPRIASKPIIVGSS CCCCCCCCCEEEECC	31.08	22505724
177	Phosphorylation	SKPIIVGSSKFRSKG CCCEEEECCCHHCCC	21.33	28857561
178	Phosphorylation	KPIIVGSSKFRSKGR CCEEEECCCHHCCCC	29.86	28857561
179	Ubiquitination	PIIVGSSKFRSKGRF CEEEECCCHHCCCCC	46.63	23000965
179 (in isoform 1)	Ubiquitination	-	46.63	21890473
179 (in isoform 2)	Ubiquitination	-	46.63	21890473
183	Ubiquitination	GSSKFRSKGRFPVLS ECCCHHCCCCCCEEE	50.26	23000965
190	Phosphorylation	KGRFPVLSYYHQDKE CCCCCEEEEECCCCC	24.71	27642862
192	Phosphorylation	RFPVLSYYHQDKEAA CCCEEEEECCCCCEE	6.93	27642862
226	Acetylation	HLLQAISKANPVNRY HHHHHHHHCCCCCCE	46.18	18528665
233	Phosphorylation	KANPVNRYMYVMDTR HCCCCCCEEEEEECH	6.39	29496907
235	Phosphorylation	NPVNRYMYVMDTRPK CCCCCEEEEEECHHH	5.45	29496907
239	Phosphorylation	RYMYVMDTRPKLNAM CEEEEEECHHHHHHH	30.67	24043423
242	Ubiquitination	YVMDTRPKLNAMANR EEEECHHHHHHHHHH	51.59	29967540
253	Ubiquitination	MANRAAGKGYENEDN HHHHHCCCCCCCCCC	54.30	21906983
253 (in isoform 1)	Ubiquitination	-	54.30	21890473
253 (in isoform 2)	Ubiquitination	-	54.30	21890473
254	Ubiquitination	ANRAAGKGYENEDNY HHHHCCCCCCCCCCC	33.78	27667366
255	Phosphorylation	NRAAGKGYENEDNYS HHHCCCCCCCCCCCC	21.04	28796482
261	Phosphorylation	GYENEDNYSNIRFQF CCCCCCCCCCEEEEE	18.54	28796482
262	Phosphorylation	YENEDNYSNIRFQFV CCCCCCCCCEEEEEE	31.84	28796482
271	Ubiquitination	IRFQFVGIENIHVMR EEEEEECEECHHHHH	2.85	22817900
272	Ubiquitination	RFQFVGIENIHVMRS EEEEECEECHHHHHH	44.17	22817900
283	Ubiquitination	VMRSSLQKLLEVNGT HHHHHHHHHHHHCCC	61.40	27667366
290	Phosphorylation	KLLEVNGTKGLSVND HHHHHCCCCCCCHHH	19.41	20363803
291	Ubiquitination	LLEVNGTKGLSVNDF HHHHCCCCCCCHHHH	60.29	21906983
291 (in isoform 1)	Ubiquitination	-	60.29	21890473
291 (in isoform 2)	Ubiquitination	-	60.29	21890473
321	Ubiquitination	VMDAAIFLAKAITVE HHHHHHHHHHCCCCC	3.80	27667366
329	Ubiquitination	AKAITVENASVLVHC HHCCCCCCCEEEEEC	32.93	22817900
449	Ubiquitination	QKEREELKLKEKTYS HHHHHHHHHCHHHHC	61.87	27667366
453	Ubiquitination	EELKLKEKTYSLWPF HHHHHCHHHHCCHHH	51.69	29967540
454	O-linked_Glycosylation	ELKLKEKTYSLWPFL HHHHCHHHHCCHHHH	21.31	29351928
456	O-linked_Glycosylation	KLKEKTYSLWPFLLE HHCHHHHCCHHHHHH	29.23	29351928
466	Ubiquitination	PFLLEDQKKYLNPLY HHHHHHHHHHHCCCC	56.56	22817900
466 (in isoform 1)	Ubiquitination	-	56.56	21890473
466 (in isoform 2)	Ubiquitination	-	56.56	21890473
467	Ubiquitination	FLLEDQKKYLNPLYS HHHHHHHHHHCCCCC	49.70	22817900
468	Phosphorylation	LLEDQKKYLNPLYSS HHHHHHHHHCCCCCC	20.81	28796482
473	Phosphorylation	KKYLNPLYSSESHRF HHHHCCCCCCCCCCE	16.06	28796482
474	Phosphorylation	KYLNPLYSSESHRFT HHHCCCCCCCCCCEE	35.00	28796482
475	Phosphorylation	YLNPLYSSESHRFTV HHCCCCCCCCCCEEE	29.57	28796482
477	Phosphorylation	NPLYSSESHRFTVLE CCCCCCCCCCEEEEC	23.16	28796482
487	Ubiquitination	FTVLEPNTVSFNFKF EEEECCCEEEEEEEH	28.39	27667366
502	Phosphorylation	WRNMYHQFDRTLHPR HHHHHHHHHCCCCCH	4.35	32142685
504	Phosphorylation	NMYHQFDRTLHPRQS HHHHHHHCCCCCHHH	40.24	32645325
504	Ubiquitination	NMYHQFDRTLHPRQS HHHHHHHCCCCCHHH	40.24	22817900
505	Ubiquitination	MYHQFDRTLHPRQSV HHHHHHCCCCCHHHH	31.12	22817900
512	Ubiquitination	TLHPRQSVFNIIMNM CCCCHHHHHHHHHCC	3.01	32015554
516	Phosphorylation	RQSVFNIIMNMNEQN HHHHHHHHHCCHHHH	1.39	32142685
518	Phosphorylation	SVFNIIMNMNEQNKQ HHHHHHHCCHHHHHH	21.51	32645325
519	Phosphorylation	VFNIIMNMNEQNKQL HHHHHHCCHHHHHHH	3.02	32142685
520	Phosphorylation	FNIIMNMNEQNKQLE HHHHHCCHHHHHHHH	42.57	32645325
521	Phosphorylation	NIIMNMNEQNKQLEK HHHHCCHHHHHHHHH	44.77	32645325
526	Ubiquitination	MNEQNKQLEKDIKDL CHHHHHHHHHHHHHH	10.63	32015554
528	Ubiquitination	EQNKQLEKDIKDLES HHHHHHHHHHHHHHH	73.65	32015554
529	Ubiquitination	QNKQLEKDIKDLESK HHHHHHHHHHHHHHH	43.74	32015554
530	Phosphorylation	NKQLEKDIKDLESKI HHHHHHHHHHHHHHH	5.76	32142685
536	Ubiquitination	DIKDLESKIKQRKNK HHHHHHHHHHHHHCC	44.54	-
543	Phosphorylation	KIKQRKNKQTDGILT HHHHHHCCCCCCCCC	58.57	32142685
543	Ubiquitination	KIKQRKNKQTDGILT HHHHHHCCCCCCCCC	58.57	29967540
544	Phosphorylation	IKQRKNKQTDGILTK HHHHHCCCCCCCCCH	54.97	32142685
545	Phosphorylation	KQRKNKQTDGILTKE HHHHCCCCCCCCCHH	37.49	32645325
546	Phosphorylation	QRKNKQTDGILTKEL HHHCCCCCCCCCHHH	39.37	32142685
547	Phosphorylation	RKNKQTDGILTKELL HHCCCCCCCCCHHHH	21.86	32142685
551	Ubiquitination	QTDGILTKELLHSVH CCCCCCCHHHHHHCC	42.81	29967540
553	Ubiquitination	DGILTKELLHSVHPE CCCCCHHHHHHCCCC	5.78	32015554
556	Phosphorylation	LTKELLHSVHPESPN CCHHHHHHCCCCCCC	23.30	23927012
561	Phosphorylation	LHSVHPESPNLKTSL HHHCCCCCCCCCCEE	24.44	29255136
563	Phosphorylation	SVHPESPNLKTSLCF HCCCCCCCCCCEECC	64.55	32645325
565	Ubiquitination	HPESPNLKTSLCFKE CCCCCCCCCEECCCC	42.58	29967540
566	Phosphorylation	PESPNLKTSLCFKEQ CCCCCCCCEECCCCC	30.05	21712546
567	Phosphorylation	ESPNLKTSLCFKEQT CCCCCCCEECCCCCC	22.89	-
571	Phosphorylation	LKTSLCFKEQTLLPV CCCEECCCCCCEEEH	48.17	32142685
571	Ubiquitination	LKTSLCFKEQTLLPV CCCEECCCCCCEEEH	48.17	32015554
574	Phosphorylation	SLCFKEQTLLPVNDA EECCCCCCEEEHHHH	31.21	23312004
584	Phosphorylation	PVNDALRTIEGSSPA EHHHHHHHHCCCCCC	25.00	23403867
588	Phosphorylation	ALRTIEGSSPADNRY HHHHHCCCCCCCCHH	21.99	29255136
589	Phosphorylation	LRTIEGSSPADNRYS HHHHCCCCCCCCHHH	34.66	29255136
595	Phosphorylation	SSPADNRYSEYAEEF CCCCCCHHHHHHHHH	16.47	28796482
596	Phosphorylation	SPADNRYSEYAEEFS CCCCCHHHHHHHHHH	22.39	28796482
598	Phosphorylation	ADNRYSEYAEEFSKS CCCHHHHHHHHHHCC	17.24	28796482
599	Phosphorylation	DNRYSEYAEEFSKSE CCHHHHHHHHHHCCC	13.04	32142685
601	Phosphorylation	RYSEYAEEFSKSEPA HHHHHHHHHHCCCCE	47.23	32645325
603	Phosphorylation	SEYAEEFSKSEPAVV HHHHHHHHCCCCEEE	38.25	27642862
605	Phosphorylation	YAEEFSKSEPAVVSL HHHHHHCCCCEEEEE	47.84	23403867
609	Ubiquitination	FSKSEPAVVSLEYGV HHCCCCEEEEEEEEE	4.38	32015554
611	Phosphorylation	KSEPAVVSLEYGVAR CCCCEEEEEEEEEEE	14.64	25159151
614	Phosphorylation	PAVVSLEYGVARMTC CEEEEEEEEEEECCC	23.38	28796482
627	Phosphorylation	TC------------- CC-------------		32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTMR6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTMR6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTMR6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTMR9_HUMAN	MTMR9	physical	12890864
RARG_HUMAN	RARG	physical	21988832
NMI_HUMAN	NMI	physical	25416956
MTUS2_HUMAN	MTUS2	physical	25416956
AMOL2_HUMAN	AMOTL2	physical	25416956
MTMR9_HUMAN	MTMR9	physical	25416956
MTMR9_HUMAN	MTMR9	physical	26344197
MTMR9_HUMAN	MTMR9	physical	27880917
MTMR6_HUMAN	MTMR6	physical	27432908
GILT_HUMAN	IFI30	physical	27432908
ZWINT_HUMAN	ZWINT	physical	27432908
CARM1_HUMAN	CARM1	physical	27432908
SOAT1_HUMAN	SOAT1	physical	27432908
BBS7_HUMAN	BBS7	physical	27432908
RL34_HUMAN	RPL34	physical	27432908

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561 AND SER-589, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561, AND MASSSPECTROMETRY.
PubMed: 17081983