MTMR9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTMR9_HUMAN
• UniProt AC: Q96QG7
• Protein Name: Myotubularin-related protein 9
• Gene Name: MTMR9
• Organism: Homo sapiens (Human).
• Sequence Length: 549
• Subcellular Localization: Cytoplasm .
• Protein Description: Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential)..
• Protein Sequence: MEFAELIKTPRVDNVVLHRPFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDKRFVGSLGTIIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSITLMYPFFYRPMFEVIEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGYIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEANNLVIWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNILRRQLAELETEDGMQESP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEFAELIK -------CCHHHHCC	9.61	22223895
8	Ubiquitination	MEFAELIKTPRVDNV CCHHHHCCCCCCCCE	66.17	22505724
39	Phosphorylation	TGHHLILSSRQDNTE ECCEEEEECCCCCHH	19.24	24719451
40	Phosphorylation	GHHLILSSRQDNTEE CCEEEEECCCCCHHH	30.43	24719451
178	Phosphorylation	EALRKVATFRHGGRF HHHHHHHHCCCCCCC	24.96	20068231
209	Phosphorylation	SGQPLTGTNGRRCKE CCCCCCCCCCCCCCC	29.30	24670416
219	Acetylation	RRCKEDEKLINATLR CCCCCCHHHHHHHHH	67.97	88555
219	Ubiquitination	RRCKEDEKLINATLR CCCCCCHHHHHHHHH	67.97	29967540
224	Phosphorylation	DEKLINATLRAGKRG CHHHHHHHHHCCCCE	16.58	28857561
229	Acetylation	NATLRAGKRGYIIDT HHHHHCCCCEEEEEC	41.48	88559
277	Phosphorylation	RYHILQESLIKLVEA HHHHHHHHHHHHHHH	23.57	24719451
541	Phosphorylation	RQLAELETEDGMQES HHHHHHHCCCCCCCC	52.59	23403867
548	Phosphorylation	TEDGMQESP------ CCCCCCCCC------	21.01	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTMR9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTMR9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTMR9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTMR9_HUMAN	MTMR9	physical	16189514
MTMR7_HUMAN	MTMR7	physical	12890864
MTMR6_HUMAN	MTMR6	physical	12890864
MTMR9_HUMAN	MTMR9	physical	12890864
KDM1A_HUMAN	KDM1A	physical	23455924
MTMR9_HUMAN	MTMR9	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
MTMR6_HUMAN	MTMR6	physical	21516116
ATIF1_HUMAN	ATPIF1	physical	27880917
DESP_HUMAN	DSP	physical	27880917
MTMR2_HUMAN	MTMR2	physical	27880917
MTMR6_HUMAN	MTMR6	physical	27880917
MTMR7_HUMAN	MTMR7	physical	27880917
MTMR8_HUMAN	MTMR8	physical	27880917
MTMR9_HUMAN	MTMR9	physical	27432908
ATIF1_HUMAN	ATPIF1	physical	27432908
WIPI3_HUMAN	WDR45B	physical	27432908
MTMR7_HUMAN	MTMR7	physical	28514442
MTMR6_HUMAN	MTMR6	physical	28514442
MTMR8_HUMAN	MTMR8	physical	28514442
APOD_HUMAN	APOD	physical	28514442
CLUS_HUMAN	CLU	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, AND MASSSPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, AND MASSSPECTROMETRY.
PubMed: 18669648