ATIF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATIF1_HUMAN
• UniProt AC: Q9UII2
• Protein Name: ATPase inhibitor, mitochondrial
• Gene Name: ATPIF1
• Organism: Homo sapiens (Human).
• Sequence Length: 106
• Subcellular Localization: Mitochondrion .
• Protein Description: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme..
• Protein Sequence: MAVTALAARTWLGVWGVRTMQARGFGSDQSENVDRGAGSIREAGGAFGKREQAEEERYFRAQSREQLAALKKHHEEEIVHHKKEIERLQKEIERHKQKIKMLKHDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	MQARGFGSDQSENVD HHHCCCCCCCCCCCC	30.16	-
39	Phosphorylation	NVDRGAGSIREAGGA CCCCCCHHHHHCCCC	20.24	23401153
41	Methylation	DRGAGSIREAGGAFG CCCCHHHHHCCCCCC	29.43	-
49	Acetylation	EAGGAFGKREQAEEE HCCCCCCCHHHHHHH	46.43	25953088
49	Succinylation	EAGGAFGKREQAEEE HCCCCCCCHHHHHHH	46.43	23954790
49	Ubiquitination	EAGGAFGKREQAEEE HCCCCCCCHHHHHHH	46.43	24816145
49	Sumoylation	EAGGAFGKREQAEEE HCCCCCCCHHHHHHH	46.43	-
57	Methylation	REQAEEERYFRAQSR HHHHHHHHHHHHHCH	38.89	-
58	Phosphorylation	EQAEEERYFRAQSRE HHHHHHHHHHHHCHH	10.74	23917254
63	Phosphorylation	ERYFRAQSREQLAAL HHHHHHHCHHHHHHH	36.48	25159151
71	Acetylation	REQLAALKKHHEEEI HHHHHHHHHHHHHHH	45.38	27178108
71	Malonylation	REQLAALKKHHEEEI HHHHHHHHHHHHHHH	45.38	26320211
72	Acetylation	EQLAALKKHHEEEIV HHHHHHHHHHHHHHH	51.55	25825284
82	Acetylation	EEEIVHHKKEIERLQ HHHHHHCHHHHHHHH	36.90	23954790
82	Succinylation	EEEIVHHKKEIERLQ HHHHHHCHHHHHHHH	36.90	23954790
82	2-Hydroxyisobutyrylation	EEEIVHHKKEIERLQ HHHHHHCHHHHHHHH	36.90	-
83	Acetylation	EEIVHHKKEIERLQK HHHHHCHHHHHHHHH	60.61	7406683
90	Succinylation	KEIERLQKEIERHKQ HHHHHHHHHHHHHHH	66.31	23954790
90	Ubiquitination	KEIERLQKEIERHKQ HHHHHHHHHHHHHHH	66.31	-
90	Malonylation	KEIERLQKEIERHKQ HHHHHHHHHHHHHHH	66.31	26320211
90	Acetylation	KEIERLQKEIERHKQ HHHHHHHHHHHHHHH	66.31	23749302
103	Succinylation	KQKIKMLKHDD---- HHHHHHHCCCC----	41.30	-
103	Ubiquitination	KQKIKMLKHDD---- HHHHHHHCCCC----	41.30	24816145
103	Succinylation	KQKIKMLKHDD---- HHHHHHHCCCC----	41.30	-
103	Acetylation	KQKIKMLKHDD---- HHHHHHHCCCC----	41.30	27178108

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
39	S	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATIF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATIF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHD3_HUMAN	CHD3	physical	16169070
CATA_HUMAN	CAT	physical	26344197
LYAG_HUMAN	GAA	physical	26344197
RNT2_HUMAN	RNASET2	physical	26344197
UCRI_HUMAN	UQCRFS1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.