MTMR8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTMR8_HUMAN
• UniProt AC: Q96EF0
• Protein Name: Myotubularin-related protein 8
• Gene Name: MTMR8
• Organism: Homo sapiens (Human).
• Sequence Length: 704
• Subcellular Localization: Nucleus envelope .
• Protein Description: Phosphatase that acts on lipids with a phosphoinositol headgroup..
• Protein Sequence: MDHITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEKLPITSLGCPLTLRCKNFRVAHFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYNPKSSKEMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFYTRCVDDELLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLGNILSQHLGSPLTNPLGFMGINGDLNTLMENGTLSREGGLRAQMDQVKSQGADLHHNCCEIVGSLRAINISGDVGISEAMGISGDMCTFEATGFSKDLGICGAMDISEATGISGNLGISEARGFSGDMGILGDTGISKASTKEADYSKHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDHITVPKVENV ---CCCCCCCCEECC	27.60	24719451
96	Phosphorylation	VCHEVYISLLKLSQP CCHHHHHHHHHHCCC	15.23	24719451
119	O-linked_Glycosylation	FSYNPKSSKEMRESG EECCCCCCHHHHHHC	38.47	30379171
128 (in isoform 2)	Ubiquitination	-	38.81	21906983
128 (in isoform 1)	Ubiquitination	-	38.81	21906983
128	Ubiquitination	EMRESGWKLIDPISD HHHHHCCEECCCHHH	38.81	22817900
244	Ubiquitination	YVVDTRPKLNAMANR EEEECHHHHHHHHHH	51.59	-
255	Acetylation	MANRAAGKGYENEDN HHHHHCCCCCCCCCC	54.30	26051181
255 (in isoform 1)	Ubiquitination	-	54.30	21906983
255	Ubiquitination	MANRAAGKGYENEDN HHHHHCCCCCCCCCC	54.30	22817900
257	Phosphorylation	NRAAGKGYENEDNYA HHHCCCCCCCCCCCC	21.04	19835603
263	Phosphorylation	GYENEDNYANIRFRF CCCCCCCCCCEEEEE	17.22	27642862
475	Phosphorylation	PDFRNPLYKGFTMYG CCCCCCCCCCEEEEE	15.43	28509920
479	Phosphorylation	NPLYKGFTMYGVLNP CCCCCCEEEEEECCC	20.39	23532336
481	Phosphorylation	LYKGFTMYGVLNPST CCCCEEEEEECCCCC	10.87	23532336
487	Phosphorylation	MYGVLNPSTVPYNIQ EEEECCCCCCCCEEE	40.75	26270265
488	Phosphorylation	YGVLNPSTVPYNIQF EEECCCCCCCCEEEE	27.10	26270265
491	Phosphorylation	LNPSTVPYNIQFWCG CCCCCCCCEEEEECC	22.14	26270265
500	Phosphorylation	IQFWCGMYNRFDKGL EEEECCHHHHCCCCC	6.62	26270265
505	Acetylation	GMYNRFDKGLQPKQS CHHHHCCCCCCCCHH	59.83	19821595
512	Phosphorylation	KGLQPKQSMLESLLE CCCCCCHHHHHHHHH	31.31	-
516	Phosphorylation	PKQSMLESLLEIKKQ CCHHHHHHHHHHHHH	34.00	-
682	Sulfoxidation	ARGFSGDMGILGDTG CCCCCCCCEECCCCC	4.03	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTMR8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTMR8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTMR8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTMR9_HUMAN	MTMR9	physical	16189514
MADD_HUMAN	MADD	physical	27880917
MTMR9_HUMAN	MTMR9	physical	27880917
TBB6_HUMAN	TUBB6	physical	27880917
MTMR8_HUMAN	MTMR8	physical	27432908
MTMR9_HUMAN	MTMR9	physical	27432908
TXND5_HUMAN	TXNDC5	physical	27432908
STIP1_HUMAN	STIP1	physical	27432908
SOAT1_HUMAN	SOAT1	physical	27432908
TAB1_HUMAN	TAB1	physical	27432908
CARM1_HUMAN	CARM1	physical	27432908
CDK4_HUMAN	CDK4	physical	27432908

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.