TXND5_HUMAN - dbPTM
TXND5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TXND5_HUMAN
UniProt AC Q8NBS9
Protein Name Thioredoxin domain-containing protein 5
Gene Name TXNDC5
Organism Homo sapiens (Human).
Sequence Length 432
Subcellular Localization Endoplasmic reticulum lumen .
Protein Description Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity)..
Protein Sequence MPARPGRLLPLLARPAALTALLLLLLGHGGGGRWGARAQEAAAAAADGPPAADGEDGQDPHSKHLYTADMFTHGIQSAAHFVMFFAPWCGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTAHSDVCSAQGVRGYPTLKLFKPGQEAVKYQGPRDFQTLENWMLQTLNEEPVTPEPEVEPPSAPELKQGLYELSASNFELHVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYVESQLQRTETGATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYAPWCGHCKTLAPTWEELSKKEFPGLAGVKIAEVDCTAERNICSKYSVRGYPTLLLFRGGKKVSEHSGGRDLDSLHRFVLSQAKDEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
42UbiquitinationGARAQEAAAAAADGP
HHHHHHHHHHHCCCC		9.2521890473
72O-linked_GlycosylationLYTADMFTHGIQSAA
EEHHHHHHHHHHHHH		16.7455828619
98PhosphorylationHCQRLQPTWNDLGDK
HHHHHCCCHHHHHHH		24.7624275569
105AcetylationTWNDLGDKYNSMEDA
CHHHHHHHHCCHHHC		44.5326051181
106PhosphorylationWNDLGDKYNSMEDAK
HHHHHHHHCCHHHCE		19.7424275569
108PhosphorylationDLGDKYNSMEDAKVY
HHHHHHCCHHHCEEE		22.0624275569
109SulfoxidationLGDKYNSMEDAKVYV
HHHHHCCHHHCEEEE		4.8730846556
113AcetylationYNSMEDAKVYVAKVD
HCCHHHCEEEEEEEE		46.5527452117
113UbiquitinationYNSMEDAKVYVAKVD
HCCHHHCEEEEEEEE		46.5521890473
1132-HydroxyisobutyrylationYNSMEDAKVYVAKVD
HCCHHHCEEEEEEEE		46.55-
115PhosphorylationSMEDAKVYVAKVDCT
CHHHCEEEEEEEECC		8.2520068231
118AcetylationDAKVYVAKVDCTAHS
HCEEEEEEEECCCCC		28.6725953088
118UbiquitinationDAKVYVAKVDCTAHS
HCEEEEEEEECCCCC		28.6721890473
122PhosphorylationYVAKVDCTAHSDVCS
EEEEEECCCCCHHHH		23.96-
125PhosphorylationKVDCTAHSDVCSAQG
EEECCCCCHHHHCCC		29.3127251275
129PhosphorylationTAHSDVCSAQGVRGY
CCCCHHHHCCCCCCC		24.39-
134MethylationVCSAQGVRGYPTLKL
HHHCCCCCCCCEEEE		45.83115919193
143UbiquitinationYPTLKLFKPGQEAVK
CCEEEEECCCCHHHH		59.6921890473
150MalonylationKPGQEAVKYQGPRDF
CCCCHHHHCCCCCCH		38.6126320211
150AcetylationKPGQEAVKYQGPRDF
CCCCHHHHCCCCCCH		38.6125953088
1502-HydroxyisobutyrylationKPGQEAVKYQGPRDF
CCCCHHHHCCCCCCH		38.61-
150UbiquitinationKPGQEAVKYQGPRDF
CCCCHHHHCCCCCCH		38.6121890473
164SulfoxidationFQTLENWMLQTLNEE
HHHHHHHHHHHCCCC		2.7530846556
174O-linked_GlycosylationTLNEEPVTPEPEVEP
HCCCCCCCCCCCCCC		32.42OGP
221MethylationAPWCGHCKALAPTWE
CCCCCCCHHHHCHHH		40.54-
2412-HydroxyisobutyrylationLEHSETVKIGKVDCT
CCCCCCEEECCEECC		53.84-
241UbiquitinationLEHSETVKIGKVDCT
CCCCCCEEECCEECC		53.84-
244AcetylationSETVKIGKVDCTQHY
CCCEEECCEECCCEE		38.0726051181
2442-HydroxyisobutyrylationSETVKIGKVDCTQHY
CCCEEECCEECCCEE		38.07-
244UbiquitinationSETVKIGKVDCTQHY
CCCEEECCEECCCEE		38.072190698
248PhosphorylationKIGKVDCTQHYELCS
EECCEECCCEEEECC		17.5828152594
251PhosphorylationKVDCTQHYELCSGNQ
CEECCCEEEECCCCC		10.7728152594
255PhosphorylationTQHYELCSGNQVRGY
CCEEEECCCCCCCCC		54.1028152594
2782-HydroxyisobutyrylationGKKVDQYKGKRDLES
CCCCCCCCCCCCHHH		52.93-
289PhosphorylationDLESLREYVESQLQR
CHHHHHHHHHHHHHH		11.77-
297O-linked_GlycosylationVESQLQRTETGATET
HHHHHHHCCCCCCCE		25.57OGP
302O-linked_GlycosylationQRTETGATETVTPSE
HHCCCCCCCEECCCC		33.27OGP
304O-linked_GlycosylationTETGATETVTPSEAP
CCCCCCCEECCCCCC		25.89OGP
306O-linked_GlycosylationTGATETVTPSEAPVL
CCCCCEECCCCCCEE		28.63OGP
308O-linked_GlycosylationATETVTPSEAPVLAA
CCCEECCCCCCEEEE		36.70OGP
344UbiquitinationAEGITFIKFYAPWCG
HHCCEEEEEECCCCC		28.29-
3652-HydroxyisobutyrylationPTWEELSKKEFPGLA
CCHHHHHHCCCCCCC		69.79-
3662-HydroxyisobutyrylationTWEELSKKEFPGLAG
CHHHHHHCCCCCCCC		62.30-
366UbiquitinationTWEELSKKEFPGLAG
CHHHHHHCCCCCCCC		62.30-
381GlutathionylationVKIAEVDCTAERNIC
CEEEEEECCCCCCCC		4.7322555962
390AcetylationAERNICSKYSVRGYP
CCCCCCCCCCCCCCC		36.8125953088
3902-HydroxyisobutyrylationAERNICSKYSVRGYP
CCCCCCCCCCCCCCC		36.81-
396PhosphorylationSKYSVRGYPTLLLFR
CCCCCCCCCEEEEEE		5.1828152594
419PhosphorylationSGGRDLDSLHRFVLS
CCCCCHHHHHHHHHH		33.1124719451
426PhosphorylationSLHRFVLSQAKDEL-
HHHHHHHHHHHHCC-		23.8421712546
429UbiquitinationRFVLSQAKDEL----
HHHHHHHHHCC----		44.06-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TXND5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TXND5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TXND5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
XPO2_HUMANCSE1Lphysical
22939629
ZN706_HUMANZNF706physical
22939629
ZNHI2_HUMANZNHIT2physical
22939629
UBXN1_HUMANUBXN1physical
22939629
UN45A_HUMANUNC45Aphysical
22939629
ZN207_HUMANZNF207physical
22939629
VATA_HUMANATP6V1Aphysical
22939629
GNAI3_HUMANGNAI3physical
22863883
KR412_HUMANKRTAP4-12physical
25416956
KRA42_HUMANKRTAP4-2physical
25416956
LHX4_HUMANLHX4physical
25416956
K1C40_HUMANKRT40physical
25416956
AL2SB_HUMANALS2CR12physical
25416956
MGT5B_HUMANMGAT5Bphysical
25416956
TRI42_HUMANTRIM42physical
25416956
KR107_HUMANKRTAP10-7physical
25416956
KR109_HUMANKRTAP10-9physical
25416956
KR108_HUMANKRTAP10-8physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
NT2NL_HUMANNOTCH2NLphysical
25416956
SPTB1_HUMANSPTBphysical
26186194
WDR59_HUMANWDR59physical
26186194
IMDH1_HUMANIMPDH1physical
26186194
KLH26_HUMANKLHL26physical
26186194
VRK3_HUMANVRK3physical
26186194
JMJD8_HUMANJMJD8physical
26186194
BRE1A_HUMANRNF20physical
26344197
BRE1B_HUMANRNF40physical
26344197
SPTB1_HUMANSPTBphysical
28514442
VRK3_HUMANVRK3physical
28514442
JMJD8_HUMANJMJD8physical
28514442
WDR59_HUMANWDR59physical
28514442
KLH26_HUMANKLHL26physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TXND5_HUMAN

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Related Literatures of Post-Translational Modification

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