MGT5B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGT5B_HUMAN
• UniProt AC: Q3V5L5
• Protein Name: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
• Gene Name: MGAT5B
• Organism: Homo sapiens (Human).
• Sequence Length: 792
• Subcellular Localization: Golgi apparatus membrane; Single-pass type II membrane protein.
• Protein Description: Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway..
• Protein Sequence: MITVNPDGKIMVRRCLVTLRPFRLFVLGIGFFTLCFLMTSLGGQFSARRLGDSPFTIRTEVMGGPESRGVLRKMSDLLELMVKRMDALARLENSSELHRAGGDLHFPADRMPPGAGLMERIQAIAQNVSDIAVKVDQILRHSLLLHSKVSEGRRDQCEAPSDPKFPDCSGKVEWMRARWTSDPCYAFFGVDGTECSFLIYLSEVEWFCPPLPWRNQTAAQRAPKPLPKVQAVFRSNLSHLLDLMGSGKESLIFMKKRTKRLTAQWALAAQRLAQKLGATQRDQKQILVHIGFLTEESGDVFSPRVLKGGPLGEMVQWADILTALYVLGHGLRVTVSLKELQSNLGVPPGRGSCPLTMPLPFDLIYTDYHGLQQMKRHMGLSFKKYRCRIRVIDTFGTEPAYNHEEYATLHGYRTNWGYWNLNPKQFMTMFPHTPDNSFMGFVSEELNETEKRLIKGGKASNMAVVYGKEASIWKLQGKEKFLGILNKYMEIHGTVYYESQRPPEVPAFVKNHGLLPQPEFQQLLRKAKLFIGFGFPYEGPAPLEAIANGCIFLQSRFSPPHSSLNHEFFRGKPTSREVFSQHPYAENFIGKPHVWTVDYNNSEEFEAAIKAIMRTQVDPYLPYEYTCEGMLERIHAYIQHQDFCRAPDPALPEAHAPQSPFVLAPNATHLEWARNTSLAPGAWPPAHALRAWLAVPGRACTDTCLDHGLICEPSFFPFLNSQDAFLKLQVPCDSTESEMNHLYPAFAQPGQECYLQKEPLLFSCAGSNTKYRRLCPCRDFRKGQVALCQGCL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MITVNPDGKI -----CEEECCCCCE	16.97	24719451
56	Phosphorylation	RLGDSPFTIRTEVMG HHCCCCCEEEEEECC	16.97	24719451
75	Phosphorylation	RGVLRKMSDLLELMV HHHHHHHHHHHHHHH	28.30	-
94	Phosphorylation	ALARLENSSELHRAG HHHHHHCHHHHHHCC	18.80	-
127	N-linked_Glycosylation	RIQAIAQNVSDIAVK HHHHHHHCHHHHHHH	26.66	UniProtKB CARBOHYD
259	Ubiquitination	IFMKKRTKRLTAQWA EEEEHHHHHHHHHHH	49.82	29967540
270	Ubiquitination	AQWALAAQRLAQKLG HHHHHHHHHHHHHHC	35.00	29967540
275	Ubiquitination	AAQRLAQKLGATQRD HHHHHHHHHCCCHHH	43.19	29967540
286	Ubiquitination	TQRDQKQILVHIGFL CHHHHHHHEEEEEEE	5.82	29967540
368	Phosphorylation	FDLIYTDYHGLQQMK CCEEEECCHHHHHHH	7.03	-
381	Phosphorylation	MKRHMGLSFKKYRCR HHHHHCCCCCCEEEE	29.32	24719451
449 (in isoform 5)	Phosphorylation	-	45.81	22468782
460 (in isoform 2)	Phosphorylation	-	30.53	22468782
466 (in isoform 5)	Phosphorylation	-	18.84	22468782
477 (in isoform 2)	Phosphorylation	-	50.99	22468782
480	Ubiquitination	WKLQGKEKFLGILNK EEECCHHHHHHHHHH	49.75	29967540
771	Phosphorylation	CAGSNTKYRRLCPCR CCCCCCCCEEECCCC	10.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGT5B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGT5B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGT5B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR195_HUMAN	KRTAP19-5	physical	25416956
KLH38_HUMAN	KLHL38	physical	25416956
KR122_HUMAN	KRTAP12-2	physical	25416956
KR261_HUMAN	KRTAP26-1	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.