dbPTM

KRA42_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KRA42_HUMAN
UniProt AC	Q9BYR5
Protein Name	Keratin-associated protein 4-2
Gene Name	KRTAP4-2
Organism	Homo sapiens (Human).
Sequence Length	136
Subcellular Localization
Protein Description	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins..
Protein Sequence	MVNSCCGSVCSDQGCGLENCCRPSCCQTTCCRTTCCRPSCCVSSCCRPQCCQSVCCQPTCCSPSCCQTTCCRTTCCRPSCCVSSCFRPQCCQSVYCQPTCCRPSCGQTTCCRTTCYRPSCCVSTCCRPTCSSGSCC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	CQTTCCRTTCCRPSC HCCCCCCCCCCCCCE	15.40	-
34	Phosphorylation	QTTCCRTTCCRPSCC CCCCCCCCCCCCCEE	7.11	-
73	Phosphorylation	CQTTCCRTTCCRPSC HCCCCCCCCCCCCCE	15.40	-
74	Phosphorylation	QTTCCRTTCCRPSCC CCCCCCCCCCCCCEE	7.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KRA42_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KRA42_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KRA42_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SPTA3_HUMAN	SPATA3	physical	25416956
ZN417_HUMAN	ZNF417	physical	25416956
TEANC_HUMAN	TCEANC	physical	25416956
LCE4A_HUMAN	LCE4A	physical	25416956
SPA24_HUMAN	SPATA24	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
LCE1B_HUMAN	LCE1B	physical	25416956
LCE2A_HUMAN	LCE2A	physical	25416956
LCE3C_HUMAN	LCE3C	physical	25416956
LCE3E_HUMAN	LCE3E	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956
KR109_HUMAN	KRTAP10-9	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
KR10B_HUMAN	KRTAP10-11	physical	25416956
KR108_HUMAN	KRTAP10-8	physical	25416956
KR103_HUMAN	KRTAP10-3	physical	25416956
NT2NL_HUMAN	NOTCH2NL	physical	25416956
KR261_HUMAN	KRTAP26-1	physical	25416956
KRA56_HUMAN	KRTAP5-6	physical	25416956

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KRA42_HUMAN

Related Literatures of Post-Translational Modification