LHX4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LHX4_HUMAN
• UniProt AC: Q969G2
• Protein Name: LIM/homeobox protein Lhx4
• Gene Name: LHX4
• Organism: Homo sapiens (Human).
• Sequence Length: 390
• Subcellular Localization: Nucleus .
• Protein Description: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA. [PubMed: 28473536]
• Protein Sequence: MMQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQHILDKFILKVLDRHWHSSCLKCADCQMQLADRCFSRAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDFVYHLHCFACIICNRQLATGDEFYLMEDGRLVCKEDYETAKQNDDSEAGAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILSELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	QLADRCFSRAGSVYC HHHHHHHHCCCCEEE	25.50	-
159	Methylation	DSEAGAKRPRTTITA CCHHHCCCCCCEECH	25.96	-
161	Methylation	EAGAKRPRTTITAKQ HHHCCCCCCEECHHH	48.84	-
228	Phosphorylation	RHRWGQFYKSVKRSR CHHHHHHHHHHHHHC	8.41	28258704
234	Phosphorylation	FYKSVKRSRGSSKQE HHHHHHHHCCCCHHH	34.96	26699800
237	Phosphorylation	SVKRSRGSSKQEKES HHHHHCCCCHHHHHC	33.00	26699800
238	Phosphorylation	VKRSRGSSKQEKESS HHHHCCCCHHHHHCH	40.98	26699800
252	Phosphorylation	SAEDCGVSDSELSFR HHHHHCCCHHHHCCC	22.24	23663014
254	Phosphorylation	EDCGVSDSELSFRED HHHCCCHHHHCCCHH	32.69	23663014
257	Phosphorylation	GVSDSELSFREDQIL CCCHHHHCCCHHHHH	20.43	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LHX4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LHX4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LHX4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LONF1_HUMAN	LONRF1	physical	25416956
CEP97_HUMAN	CEP97	physical	26186194
ZN574_HUMAN	ZNF574	physical	26186194
CHM1A_HUMAN	CHMP1A	physical	26186194
CYFP2_HUMAN	CYFIP2	physical	26186194
CYFP1_HUMAN	CYFIP1	physical	26186194
P52K_HUMAN	PRKRIR	physical	26186194
ARID2_HUMAN	ARID2	physical	26186194
LDB1_HUMAN	LDB1	physical	26186194
ISL2_HUMAN	ISL2	physical	26186194
ISL1_HUMAN	ISL1	physical	26186194
SMAD4_HUMAN	SMAD4	physical	26186194
ABI2_HUMAN	ABI2	physical	26186194
ABI1_HUMAN	ABI1	physical	26186194
WASF2_HUMAN	WASF2	physical	26186194
CA052_HUMAN	C1orf52	physical	26186194
DCAF5_HUMAN	DCAF5	physical	26186194
SMAD4_HUMAN	SMAD4	physical	28514442
LDB1_HUMAN	LDB1	physical	28514442
P52K_HUMAN	PRKRIR	physical	28514442
ISL2_HUMAN	ISL2	physical	28514442
CHM1A_HUMAN	CHMP1A	physical	28514442
WASF2_HUMAN	WASF2	physical	28514442
T22D4_HUMAN	TSC22D4	physical	28514442
ABI2_HUMAN	ABI2	physical	28514442
ISL1_HUMAN	ISL1	physical	28514442
ABI1_HUMAN	ABI1	physical	28514442
ARID2_HUMAN	ARID2	physical	28514442
CA052_HUMAN	C1orf52	physical	28514442
CYFP2_HUMAN	CYFIP2	physical	28514442
ZN574_HUMAN	ZNF574	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.