P52K_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P52K_HUMAN
• UniProt AC: O43422
• Protein Name: 52 kDa repressor of the inhibitor of the protein kinase
• Gene Name: THAP12 {ECO:0000312|HGNC:HGNC:9440}
• Organism: Homo sapiens (Human).
• Sequence Length: 761
• Protein Description: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth..
• Protein Sequence: MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIDETSEQEQKHKETNNSNAQNPSEEEGEGQDEDILPLTLEEKENKEYLKSLFEILILMGKQNIPLDGHEADEIPEGLFTPDNFQALLECRINSGEEVLRKRFETTAVNTLFCSKTQQRQMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDESHNLREEFIGFLPYEADAEILAVKFHTMITEKWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAIYTLCSSCALNMWLAKSVPVMGVSVALGTIEEVCSFFHRSPQLLLELDNVISVLFQNSKERGKELKEICHSQWTGRHDAFEILVELLQALVLCLDGINSDTNIRWNNYIAGRAFVLCSAVSDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAAGSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAHQGNLESQLTSESYYKETLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTSKSELPTDNSETVENT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	APNCTRKSTQSDLAF CCCCCCCCCCCCCHH	28.52	28555341
47	Phosphorylation	RADLEDKTPDQLNKH HCCCCCCCHHHHHHH	44.40	28555341
64	Phosphorylation	LCAKHFETSMICRTS HHHHHHCCCEEECCC	23.74	24719451
71	Phosphorylation	TSMICRTSPYRTVLR CCEEECCCCCCHHCC	10.69	23898821
84	Phosphorylation	LRDNAIPTIFDLTSH CCCCCCCCHHHHHHH	28.32	30576142
89	Phosphorylation	IPTIFDLTSHLNNPH CCCHHHHHHHCCCCC	18.88	28555341
90	Phosphorylation	PTIFDLTSHLNNPHS CCHHHHHHHCCCCCH	33.02	27251275
97	Phosphorylation	SHLNNPHSRHRKRIK HHCCCCCHHHHHHHH	30.92	30576142
107	Phosphorylation	RKRIKELSEDEIRTL HHHHHHCCHHHHHHH	44.06	25159151
122	Phosphorylation	KQKKIDETSEQEQKH HHHHCCCCHHHHHHH	33.54	27251275
123	Phosphorylation	QKKIDETSEQEQKHK HHHCCCCHHHHHHHH	34.92	27251275
132	Phosphorylation	QEQKHKETNNSNAQN HHHHHHHHCCCCCCC	44.49	21955146
135	Phosphorylation	KHKETNNSNAQNPSE HHHHHCCCCCCCCCC	35.30	21955146
141	Phosphorylation	NSNAQNPSEEEGEGQ CCCCCCCCCCCCCCC	66.25	30266825
156	Phosphorylation	DEDILPLTLEEKENK CCCCCCCCCCHHHCH	30.13	30266825
160	Ubiquitination	LPLTLEEKENKEYLK CCCCCCHHHCHHHHH	58.15	-
330	Phosphorylation	EYCRGQAYIVSSGFS HHHCCCEEEECCCCC	8.25	30576142
345	Phosphorylation	SKMKVVASRLLEKYP HHHHHHHHHHHHHCC	16.32	-
383	Phosphorylation	GVSVALGTIEEVCSF CCHHHHHCHHHHHHH	26.51	27732954
389	Phosphorylation	GTIEEVCSFFHRSPQ HCHHHHHHHHHCCHH	35.80	27732954
513	Phosphorylation	DVFFAAGSLTAVLHS HHHHHHHHHHHHHHH	20.16	-
515	Phosphorylation	FFAAGSLTAVLHSLN HHHHHHHHHHHHHHH	19.20	-
555	Acetylation	IQMKLPGKFRRAHQG HHHCCCCCHHHHHCC	33.48	26051181
566	Phosphorylation	AHQGNLESQLTSESY HHCCCHHHHHCCHHH	33.39	9447982
569	Phosphorylation	GNLESQLTSESYYKE CCHHHHHCCHHHHHH	23.86	23186163
570	Phosphorylation	NLESQLTSESYYKET CHHHHHCCHHHHHHH	32.89	23186163
579	Phosphorylation	SYYKETLSVPTVEHI HHHHHHCCCCCHHHH	33.21	-
595	Phosphorylation	QELKDIFSEQHLKAL HHHHHHCCHHHHHHH	36.36	-
600	Acetylation	IFSEQHLKALKCLSL HCCHHHHHHHHHHHC	49.93	25953088
603	Ubiquitination	EQHLKALKCLSLVPS HHHHHHHHHHHCCHH	37.68	-
606	Phosphorylation	LKALKCLSLVPSVMG HHHHHHHHCCHHHHH	36.47	21406692
610	Phosphorylation	KCLSLVPSVMGQLKF HHHHCCHHHHHCCCC	19.77	21406692
654	Ubiquitination	IKWKHRGKDIELPST EEEHHCCCCCCCCHH	56.33	-
654	Acetylation	IKWKHRGKDIELPST EEEHHCCCCCCCCHH	56.33	23236377
705	Ubiquitination	ENGRKRLKAYLRNTL HHHHHHHHHHHHHHC	38.73	-
707	Phosphorylation	GRKRLKAYLRNTLTD HHHHHHHHHHHHCCC	12.47	22210691
711	Phosphorylation	LKAYLRNTLTDQRSS HHHHHHHHCCCHHHC	25.30	22210691
713	Phosphorylation	AYLRNTLTDQRSSNL HHHHHHCCCHHHCCE	28.22	22210691
747 (in isoform 1)	Ubiquitination	-	39.90	21906983
747	Ubiquitination	YIKLYTSKSELPTDN HHHHHCCCCCCCCCC	39.90	2190698
752	Phosphorylation	TSKSELPTDNSETVE CCCCCCCCCCCCCCC	61.51	25002506
755	Phosphorylation	SELPTDNSETVENT- CCCCCCCCCCCCCC-	37.14	25159151
757	Phosphorylation	LPTDNSETVENT--- CCCCCCCCCCCC---	32.70	25002506

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P52K_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P52K_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P52K_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNJC3_HUMAN	DNAJC3	physical	9447982
STK4_HUMAN	STK4	physical	12384512
P52K_HUMAN	PRKRIR	physical	12384512
P53_HUMAN	TP53	physical	12384512
DDX58_HUMAN	DDX58	physical	21910972
TACC1_HUMAN	TACC1	physical	25416956
MAPK3_HUMAN	MAPKAPK3	physical	20484669
MAPK2_HUMAN	MAPKAPK2	physical	20484669
E2AK2_HUMAN	EIF2AK2	physical	20484669

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.