ISL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ISL2_HUMAN
• UniProt AC: Q96A47
• Protein Name: Insulin gene enhancer protein ISL-2
• Gene Name: ISL2
• Organism: Homo sapiens (Human).
• Sequence Length: 359
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways..
• Protein Sequence: MVDIIFHYPFLGAMGDHSKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPDAGSGRQPALRPHVHKQTEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHSDKTSLQGLTGTPLVAGSPIRHENAVQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGNSSGSDVTSLSSQLPDTPNSMVPSPVET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	DQFILRVSPDLEWHA CEEEEEECCCCHHHH	13.28	27732954
154	Phosphorylation	LERAAAGSPRSPGPL HCHHHCCCCCCCCCC	16.65	20164059
157	Phosphorylation	AAAGSPRSPGPLPGA HHCCCCCCCCCCCCC	37.28	22617229
201	Ubiquitination	VRTVLNEKQLHTLRT HHHHCCHHHHHHHHH	58.02	32015554
228	Phosphorylation	KEQLVEMTGLSPRVI HHHHHHHHCCCHHHH	22.82	27050516
231	Phosphorylation	LVEMTGLSPRVIRVW HHHHHCCCHHHHHHH	16.41	25159151
265	Phosphorylation	QQQHSDKTSLQGLTG HHHHCCCCCCCCCCC	39.39	24667141
266	Phosphorylation	QQHSDKTSLQGLTGT HHHCCCCCCCCCCCC	25.16	24667141
271	Phosphorylation	KTSLQGLTGTPLVAG CCCCCCCCCCCEECC	45.92	30108239
273	Phosphorylation	SLQGLTGTPLVAGSP CCCCCCCCCEECCCC	14.28	30108239
279	Phosphorylation	GTPLVAGSPIRHENA CCCEECCCCCCCCCC	13.86	30631047
290	Phosphorylation	HENAVQGSAVEVQTY CCCCCCCCEEEEEEE	16.43	30108239
296	Phosphorylation	GSAVEVQTYQPPWKA CCEEEEEEECCCHHH	29.33	28122231
297	Phosphorylation	SAVEVQTYQPPWKAL CEEEEEEECCCHHHH	11.26	28122231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ISL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ISL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ISL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LHX3_HUMAN	LHX3	physical	9452425
ISL1_HUMAN	ISL1	physical	9452425

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, AND MASSSPECTROMETRY.
PubMed: 19690332

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154 AND SER-157, ANDMASS SPECTROMETRY.
PubMed: 18669648

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, AND MASSSPECTROMETRY.
PubMed: 15302935