CA052_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CA052_HUMAN
• UniProt AC: Q8N6N3
• Protein Name: UPF0690 protein C1orf52
• Gene Name: C1orf52
• Organism: Homo sapiens (Human).
• Sequence Length: 182
• Protein Sequence: MAAEEKDPLSYFAAYGSSSSGSSDEEDNIEPEETSRRTPDPAKSAGGCRNKAEKRLPGPDELFRSVTRPAFLYNPLNKQIDWERHVVKAPEEPPKEFKIWKSNYVPPPETYTTEKKPPPPELDMAIKWSNIYEDNGDDAPQNAKKARLLPEGEETLESDDEKDEHTSKKRKVEPGEPAKKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	DNIEPEETSRRTPDP CCCCHHHHHCCCCCH	26.35	26074081
35	Phosphorylation	NIEPEETSRRTPDPA CCCHHHHHCCCCCHH	24.05	26074081
38	Phosphorylation	PEETSRRTPDPAKSA HHHHHCCCCCHHHHC	30.82	26074081
44	Phosphorylation	RTPDPAKSAGGCRNK CCCCHHHHCCCCCCH	33.96	26074081
65	Phosphorylation	GPDELFRSVTRPAFL CHHHHHHHCCCCHHH	22.10	25159151
67	Phosphorylation	DELFRSVTRPAFLYN HHHHHHCCCCHHHCC	31.98	21712546
73	Phosphorylation	VTRPAFLYNPLNKQI CCCCHHHCCCCHHCC	14.31	27642862
78 (in isoform 3)	Ubiquitination	-	57.20	21890473
78 (in isoform 1)	Ubiquitination	-	57.20	21890473
78	Ubiquitination	FLYNPLNKQIDWERH HHCCCCHHCCCHHHC	57.20	21963094
78 (in isoform 2)	Ubiquitination	-	57.20	21890473
101	Ubiquitination	PKEFKIWKSNYVPPP CCCCCCCCCCCCCCC	32.09	29967540
102	Phosphorylation	KEFKIWKSNYVPPPE CCCCCCCCCCCCCCC	20.56	-
104	Phosphorylation	FKIWKSNYVPPPETY CCCCCCCCCCCCCCC	22.79	-
113	Phosphorylation	PPPETYTTEKKPPPP CCCCCCCCCCCCCCC	35.08	-
129	Phosphorylation	LDMAIKWSNIYEDNG CCEEEEHHHHCCCCC	14.35	21945579
132	Phosphorylation	AIKWSNIYEDNGDDA EEEHHHHCCCCCCCC	22.83	21945579
144	Acetylation	DDAPQNAKKARLLPE CCCCCHHHHHCCCCC	55.29	23236377
144	Ubiquitination	DDAPQNAKKARLLPE CCCCCHHHHHCCCCC	55.29	29967540
155	Phosphorylation	LLPEGEETLESDDEK CCCCCCHHHCCCCCC	31.36	25159151
158	Phosphorylation	EGEETLESDDEKDEH CCCHHHCCCCCCCHH	54.17	29255136
166	Phosphorylation	DDEKDEHTSKKRKVE CCCCCHHCCCCCCCC	39.95	22167270
167	Phosphorylation	DEKDEHTSKKRKVEP CCCCHHCCCCCCCCC	37.78	22167270
179	Acetylation	VEPGEPAKKKK---- CCCCCCCCCCC----	75.69	25953088
182	Ubiquitination	GEPAKKKK------- CCCCCCCC-------	74.56	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CA052_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CA052_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CA052_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CA052_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158, AND MASSSPECTROMETRY.
PubMed: 18669648

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158, AND MASSSPECTROMETRY.
PubMed: 17287340

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158, AND MASSSPECTROMETRY.
PubMed: 17081983

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-132, AND MASSSPECTROMETRY.
PubMed: 15592455