dbPTM

CEP97_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CEP97_HUMAN
UniProt AC	Q8IW35
Protein Name	Centrosomal protein of 97 kDa
Gene Name	CEP97
Organism	Homo sapiens (Human).
Sequence Length	865
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
Protein Description	Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome..
Protein Sequence	MAVARVDAALPPGEGSVVNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQSQNEELSPLVPVETRASLIPEHSSPVQDCQISQESEPVIQVNSWVGINSNDDQLFAVKNNFPASVHTTRYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPLSPTVELRLQGINLGLEDDGVADESVKGLESQVLDKEEEQPLWAANENSVQMMRSEINTEVNEKAGLLPCPEPTIISAILKDDNHSLTFFPESTEQKQSDIKKPENTQPENKETISQATSEKLPMILTQRSVALGQDKVALQKLNDAATKLQACWRGFYARNYNPQAKDVRYEIRLRRMQEHIVCLTDEIRRLRKERDEERIKKFVQEEAFRFLWNQVRSLQVWQQTVDQRLSSWHTDVPPISSTLVPSKHPLFTQSQESSCDQNADWFIASDVAPQEKSLPEFPDSGFHSSLTEQVHSLQHSLDFEKSSTEGSESSIMGNSIDTVRYGKESDLGDVSEEHGEWNKESSNNEQDNSLLEQYLTSVQQLEDADERTNFDTETRDSKLHIACFPVQLDTLSDGASVDESHGISPPLQGEISQTQENSKLNAEVQGQQPECDSTFQLLHVGVTV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Ubiquitination	WSGQGLQKLGPNLPC CCCCCHHHHCCCCCC	61.53	-
45	Ubiquitination	IHTLILDKNQIIKLE EEEEEECHHCEEEEC	47.51	-
45 (in isoform 2)	Ubiquitination	-	47.51	-
50	Acetylation	LDKNQIIKLENLEKC ECHHCEEEECCHHHH	51.91	25953088
50	Ubiquitination	LDKNQIIKLENLEKC ECHHCEEEECCHHHH	51.91	-
64	Phosphorylation	CKRLIQLSVANNRLV HHHHHHHHHHCCHHH	11.65	24670416
144	Ubiquitination	SQIGDLSKLVSLKTL HHHHHHHHHHCHHHH	61.27	-
241	Ubiquitination	DGYVISQKESLKAEW CCEEEECHHHHCHHH	42.34	-
241 (in isoform 2)	Ubiquitination	-	42.34	-
245	Ubiquitination	ISQKESLKAEWLYSQ EECHHHHCHHHHHHC	54.24	-
254	Ubiquitination	EWLYSQGKGRAYRPG HHHHHCCCCCCCCCC	37.27	-
292	Ubiquitination	AEDAKLEKILSKQRF HHHHHHHHHHHHHHH	60.42	-
308	Phosphorylation	QRQLMNQSQNEELSP HHHHHCHHCCCCCCC	29.93	25159151
314	Phosphorylation	QSQNEELSPLVPVET HHCCCCCCCCCCCHH	21.33	25159151
321	Phosphorylation	SPLVPVETRASLIPE CCCCCCHHHHHHCCC	31.59	20068231
324	Phosphorylation	VPVETRASLIPEHSS CCCHHHHHHCCCCCC	24.44	26074081
330	Phosphorylation	ASLIPEHSSPVQDCQ HHHCCCCCCCCCCCC	34.37	26074081
331	Phosphorylation	SLIPEHSSPVQDCQI HHCCCCCCCCCCCCC	30.88	26074081
339	Phosphorylation	PVQDCQISQESEPVI CCCCCCCCCCCCCEE	11.30	26074081
342	Phosphorylation	DCQISQESEPVIQVN CCCCCCCCCCEEEEE	39.29	26074081
350	Phosphorylation	EPVIQVNSWVGINSN CCEEEEEEEEEECCC	25.04	28348404
356	Phosphorylation	NSWVGINSNDDQLFA EEEEEECCCCCCEEE	39.45	28348404
371	Phosphorylation	VKNNFPASVHTTRYS EECCCCCEEEECCCC	18.05	25159151
377	Phosphorylation	ASVHTTRYSRNDLHL CEEEECCCCCCCCCH	15.19	28555341
378	Phosphorylation	SVHTTRYSRNDLHLE EEEECCCCCCCCCHH	22.71	29449344
389	Phosphorylation	LHLEDIQTDEDKLNC CCHHHHCCCHHHHCC	41.51	27080861
397	Phosphorylation	DEDKLNCSLLSSEST CHHHHCCCCCCCCCC	31.13	22199227
400	Phosphorylation	KLNCSLLSSESTFMP HHCCCCCCCCCCCCC	37.03	22199227
401	Phosphorylation	LNCSLLSSESTFMPV HCCCCCCCCCCCCCC	35.22	22199227
403	Phosphorylation	CSLLSSESTFMPVAS CCCCCCCCCCCCCCC	28.97	22199227
404	Phosphorylation	SLLSSESTFMPVASG CCCCCCCCCCCCCCC	21.65	22199227
410	Phosphorylation	STFMPVASGLSPLSP CCCCCCCCCCCCCCC	40.27	28450419
413	Phosphorylation	MPVASGLSPLSPTVE CCCCCCCCCCCCCEE	27.59	23898821
416	Phosphorylation	ASGLSPLSPTVELRL CCCCCCCCCCEEEEE	23.16	25159151
418	Phosphorylation	GLSPLSPTVELRLQG CCCCCCCCEEEEECC	24.20	28102081
439	Phosphorylation	DDGVADESVKGLESQ CCCCCCHHHCCHHHH	29.67	30576142
445	Phosphorylation	ESVKGLESQVLDKEE HHHCCHHHHCCCCCC	30.54	21815630
478	Ubiquitination	INTEVNEKAGLLPCP HHHHHHHHCCCCCCC	42.42	-
488	Phosphorylation	LLPCPEPTIISAILK CCCCCCCCEEEEEEC	29.31	27251275
491	Phosphorylation	CPEPTIISAILKDDN CCCCCEEEEEECCCC	12.85	24719451
495	Ubiquitination	TIISAILKDDNHSLT CEEEEEECCCCCCCE	57.85	-
500	Phosphorylation	ILKDDNHSLTFFPES EECCCCCCCEECCCC	35.05	23401153
502	Phosphorylation	KDDNHSLTFFPESTE CCCCCCCEECCCCCC	26.67	29255136
507	Phosphorylation	SLTFFPESTEQKQSD CCEECCCCCCCCHHH	37.17	23403867
511	Ubiquitination	FPESTEQKQSDIKKP CCCCCCCCHHHCCCC	45.60	-
530	Phosphorylation	PENKETISQATSEKL CCCHHHHHHHHHCCC	22.60	-
534	Phosphorylation	ETISQATSEKLPMIL HHHHHHHHCCCCEEH	35.43	25627689
542	Phosphorylation	EKLPMILTQRSVALG CCCCEEHHHHHHHCC	15.83	17525332
545	Phosphorylation	PMILTQRSVALGQDK CEEHHHHHHHCCCCH	11.26	25159151
552	Acetylation	SVALGQDKVALQKLN HHHCCCCHHHHHHHH	22.86	23236377
552	Ubiquitination	SVALGQDKVALQKLN HHHCCCCHHHHHHHH	22.86	-
552 (in isoform 2)	Ubiquitination	-	22.86	-
557	Ubiquitination	QDKVALQKLNDAATK CCHHHHHHHHHHHHH	50.54	-
557 (in isoform 2)	Ubiquitination	-	50.54	-
564	Acetylation	KLNDAATKLQACWRG HHHHHHHHHHHHHHH	33.60	23236377
564	Ubiquitination	KLNDAATKLQACWRG HHHHHHHHHHHHHHH	33.60	-
564 (in isoform 2)	Ubiquitination	-	33.60	-
582	Ubiquitination	RNYNPQAKDVRYEIR CCCCCCCCCHHHHHH	52.05	-
582 (in isoform 2)	Ubiquitination	-	52.05	-
617 (in isoform 2)	Ubiquitination	-	46.51	-
618	Ubiquitination	RDEERIKKFVQEEAF CCHHHHHHHHHHHHH	48.69	-
618 (in isoform 2)	Ubiquitination	-	48.69	-
648	Phosphorylation	TVDQRLSSWHTDVPP HHHHHHHHHCCCCCC	27.71	28555341
651	Phosphorylation	QRLSSWHTDVPPISS HHHHHHCCCCCCCCC	32.22	28555341
657	Phosphorylation	HTDVPPISSTLVPSK CCCCCCCCCCCCCCC	24.04	28555341
669	Phosphorylation	PSKHPLFTQSQESSC CCCCCCCCCCCCCCC	34.69	28857561
671	Phosphorylation	KHPLFTQSQESSCDQ CCCCCCCCCCCCCCC	32.62	28857561
674	Phosphorylation	LFTQSQESSCDQNAD CCCCCCCCCCCCCCC	28.73	28857561
675	Phosphorylation	FTQSQESSCDQNADW CCCCCCCCCCCCCCE	22.44	24719451
694	Phosphorylation	DVAPQEKSLPEFPDS CCCCCCCCCCCCCCC	48.69	-
708	Phosphorylation	SGFHSSLTEQVHSLQ CCCCHHHHHHHHHHH	26.73	-
717	Phosphorylation	QVHSLQHSLDFEKSS HHHHHHHHCCCCCCC	19.37	27251275
723	Phosphorylation	HSLDFEKSSTEGSES HHCCCCCCCCCCCCC	34.98	25159151
724	Phosphorylation	SLDFEKSSTEGSESS HCCCCCCCCCCCCCH	41.36	25159151
725	Phosphorylation	LDFEKSSTEGSESSI CCCCCCCCCCCCCHH	52.00	28985074
728	Phosphorylation	EKSSTEGSESSIMGN CCCCCCCCCCHHCCC	28.24	26471730
730	Phosphorylation	SSTEGSESSIMGNSI CCCCCCCCHHCCCCC	27.19	27251275
731	Phosphorylation	STEGSESSIMGNSID CCCCCCCHHCCCCCC	16.73	27251275
733	Sulfoxidation	EGSESSIMGNSIDTV CCCCCHHCCCCCCEE	4.49	21406390
736	Phosphorylation	ESSIMGNSIDTVRYG CCHHCCCCCCEEECC	18.99	21815630
739	Phosphorylation	IMGNSIDTVRYGKES HCCCCCCEEECCCCC	12.76	27251275
742	Phosphorylation	NSIDTVRYGKESDLG CCCCEEECCCCCCCC	28.36	30576142
744	Ubiquitination	IDTVRYGKESDLGDV CCEEECCCCCCCCCC	45.14	-
746	Phosphorylation	TVRYGKESDLGDVSE EEECCCCCCCCCCCH	41.44	30576142
752	Phosphorylation	ESDLGDVSEEHGEWN CCCCCCCCHHHCCCC	41.84	30576142
762	Phosphorylation	HGEWNKESSNNEQDN HCCCCCCCCCCHHHH	39.72	29116813
763	Phosphorylation	GEWNKESSNNEQDNS CCCCCCCCCCHHHHH	44.78	21712546
770	Phosphorylation	SNNEQDNSLLEQYLT CCCHHHHHHHHHHHH	42.49	21712546
775	Phosphorylation	DNSLLEQYLTSVQQL HHHHHHHHHHHHHHH	11.54	29116813
777	Phosphorylation	SLLEQYLTSVQQLED HHHHHHHHHHHHHHC	23.17	20873877
778	Phosphorylation	LLEQYLTSVQQLEDA HHHHHHHHHHHHHCC	18.48	20873877
793	Phosphorylation	DERTNFDTETRDSKL CHHCCCCCCCCCCCE	34.81	28348404
795	Phosphorylation	RTNFDTETRDSKLHI HCCCCCCCCCCCEEE	41.70	26074081
798	Phosphorylation	FDTETRDSKLHIACF CCCCCCCCCEEEEEE	33.55	26074081
799	Ubiquitination	DTETRDSKLHIACFP CCCCCCCCEEEEEEE	48.66	-
811	Phosphorylation	CFPVQLDTLSDGASV EEEEEECCCCCCCCC	36.43	28122231
813	Phosphorylation	PVQLDTLSDGASVDE EEEECCCCCCCCCCH	35.77	28348404
817	Phosphorylation	DTLSDGASVDESHGI CCCCCCCCCCHHCCC	35.31	28348404
821	Phosphorylation	DGASVDESHGISPPL CCCCCCHHCCCCCCC	23.66	28348404
825	Phosphorylation	VDESHGISPPLQGEI CCHHCCCCCCCCCCC	25.67	25159151
833	Phosphorylation	PPLQGEISQTQENSK CCCCCCCCCCHHHHH	23.91	20873877
835	Phosphorylation	LQGEISQTQENSKLN CCCCCCCCHHHHHHC	30.93	20873877
839	Phosphorylation	ISQTQENSKLNAEVQ CCCCHHHHHHCHHHC	37.45	26552605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	KCTD10	Q9H3F6	PMID:30404837

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CEP97_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CEP97_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CP110_HUMAN	CCP110	physical	17719545
CP110_HUMAN	CCP110	physical	22261722
ARPC2_HUMAN	ARPC2	physical	22261722
SNP23_HUMAN	SNAP23	physical	22261722
LYN_HUMAN	LYN	physical	22261722
ARP3_HUMAN	ACTR3	physical	22261722
CAND1_HUMAN	CAND1	physical	22261722
SGT1_HUMAN	SUGT1	physical	22261722
GBB4_HUMAN	GNB4	physical	22261722
NEUL4_HUMAN	NEURL4	physical	22261722
CP110_HUMAN	CCP110	physical	23486064
NEUL4_HUMAN	NEURL4	physical	23486064
ALMS1_HUMAN	ALMS1	physical	26638075
CP110_HUMAN	CCP110	physical	26638075
CE104_HUMAN	CEP104	physical	26638075
CLH1_HUMAN	CLTC	physical	26638075
HAUS8_HUMAN	HAUS8	physical	26638075
MPP9_HUMAN	MPHOSPH9	physical	26638075
NAA15_HUMAN	NAA15	physical	26638075
NEDD1_HUMAN	NEDD1	physical	26638075
RAB2A_HUMAN	RAB2A	physical	26638075
RAB35_HUMAN	RAB35	physical	26638075
RAB5B_HUMAN	RAB5B	physical	26638075
RAB8A_HUMAN	RAB8A	physical	26638075
SMG7_HUMAN	SMG7	physical	26638075
SGT1_HUMAN	SUGT1	physical	26638075
SP16H_HUMAN	SUPT16H	physical	26638075
TNIP1_HUMAN	TNIP1	physical	26638075
TNR6B_HUMAN	TNRC6B	physical	26638075
ASPP2_HUMAN	TP53BP2	physical	26638075
WDR83_HUMAN	WDR83	physical	26638075
XRN1_HUMAN	XRN1	physical	26638075
YTHD1_HUMAN	YTHDF1	physical	26638075
CENPJ_HUMAN	CENPJ	physical	26638075
ACTBL_HUMAN	ACTBL2	physical	27173435
SORL_HUMAN	SORL1	physical	27173435
CP110_HUMAN	CCP110	physical	27173435
CFA91_HUMAN	MAATS1	physical	27173435
IQCB1_HUMAN	IQCB1	physical	27173435
U119A_HUMAN	UNC119	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CEP97_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-308, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-763; SER-770; THR-811;SER-813 AND SER-817, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-542, AND MASSSPECTROMETRY.	17525332 [Abstract]