GBB4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBB4_HUMAN
• UniProt AC: Q9HAV0
• Protein Name: Guanine nucleotide-binding protein subunit beta-4
• Gene Name: GNB4
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
• Protein Sequence: MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSELEQLRQ ------CHHHHHHHH	51.38	-
2	Phosphorylation	------MSELEQLRQ ------CHHHHHHHH	51.38	25159151
23	Ubiquitination	NQIQDARKACNDATL HHHHHHHHHHCCCEE	60.04	23000965
34	Phosphorylation	DATLVQITSNMDSVG CCEEEEEECCCCCCC	9.28	-
50	Phosphorylation	IQMRTRRTLRGHLAK HHHHCHHHHHHHHHH	19.95	-
57	Ubiquitination	TLRGHLAKIYAMHWG HHHHHHHHHHHHHCC	42.48	22817900
72	O-linked_Glycosylation	YDSRLLVSASQDGKL CCCEEEEEECCCCCE	23.36	29351928
72	Phosphorylation	YDSRLLVSASQDGKL CCCEEEEEECCCCCE	23.36	-
74	Phosphorylation	SRLLVSASQDGKLII CEEEEEECCCCCEEE	22.69	21082442
78	Ubiquitination	VSASQDGKLIIWDSY EEECCCCCEEEEECC	44.81	30230243
78	Acetylation	VSASQDGKLIIWDSY EEECCCCCEEEEECC	44.81	30588981
84	Phosphorylation	GKLIIWDSYTTNKMH CCEEEEECCCCCCCE	14.91	28152594
85	Phosphorylation	KLIIWDSYTTNKMHA CEEEEECCCCCCCEE	18.34	28152594
86	Phosphorylation	LIIWDSYTTNKMHAI EEEEECCCCCCCEEE	28.04	28152594
87	Phosphorylation	IIWDSYTTNKMHAIP EEEECCCCCCCEEEE	25.30	28152594
111	Phosphorylation	AYAPSGNYVACGGLD EECCCCCEEEECCHH	7.92	-
127	Ubiquitination	ICSIYNLKTREGNVR HEEEEECCCCCCCEE	41.73	21963094
136	Phosphorylation	REGNVRVSRELPGHT CCCCEEECEECCCCC	14.96	27794612
145	Phosphorylation	ELPGHTGYLSCCRFL ECCCCCCEEEEEEEC	9.15	29496907
208	Phosphorylation	SGACDASSKLWDIRD HCCCCCHHHCCCCCC	33.22	20068231
209	Ubiquitination	GACDASSKLWDIRDG CCCCCHHHCCCCCCC	51.61	21963094
209	Acetylation	GACDASSKLWDIRDG CCCCCHHHCCCCCCC	51.61	26051181
219	Methylation	DIRDGMCRQSFTGHV CCCCCCCCCCCCCCC	26.70	-
266	Phosphorylation	QELLLYSHDNIICGI CEEEEEECCCEEECC	20.69	-
280	Ubiquitination	ITSVAFSKSGRLLLA CEEEEECCCCCEEEE	50.94	21963094
301	Ubiquitination	CNVWDTLKGDRAGVL CCCHHHCCCCCCEEE	61.94	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBB4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBB4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBB4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHLP_HUMAN	PDCL	physical	19376773
GBG2_HUMAN	GNG2	physical	19376773
GNAI1_HUMAN	GNAI1	physical	16371464
GNAI2_HUMAN	GNAI2	physical	16371464
GNAI3_HUMAN	GNAI3	physical	16371464
GBG1_HUMAN	GNGT1	physical	12782285
GBG2_HUMAN	GNG2	physical	12782285
GBG3_HUMAN	GNG3	physical	12782285
GBG4_HUMAN	GNG4	physical	12782285
GBG5_HUMAN	GNG5	physical	12782285
GBG7_HUMAN	GNG7	physical	12782285
GBG8_HUMAN	GNG8	physical	12782285
GBG10_HUMAN	GNG10	physical	12782285
GBG11_HUMAN	GNG11	physical	12782285
GBG12_HUMAN	GNG12	physical	12782285
GBG13_HUMAN	GNG13	physical	12782285
GNA11_HUMAN	GNA11	physical	26344197
GNAQ_HUMAN	GNAQ	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615185: Charcot-Marie-Tooth disease, dominant, intermediate type, F (CMTDIF)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.