GBG11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBG11_HUMAN
• UniProt AC: P61952
• Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
• Gene Name: GNG11
• Organism: Homo sapiens (Human).
• Sequence Length: 73
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
• Protein Sequence: MPALHIEDLPEKEKLKMEVEQLRKEVKLQRQQVSKCSEEIKNYIEERSGEDPLVKGIPEDKNPFKEKGSCVIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	HIEDLPEKEKLKMEV CHHCCCHHHHHHHHH	59.20	-
14	Ubiquitination	EDLPEKEKLKMEVEQ HCCCHHHHHHHHHHH	65.56	-
35	Ubiquitination	LQRQQVSKCSEEIKN HHHHHHHHHHHHHHH	42.81	-
41	Ubiquitination	SKCSEEIKNYIEERS HHHHHHHHHHHHHHH	47.15	-
55	Ubiquitination	SGEDPLVKGIPEDKN HCCCCCCCCCCCCCC	59.82	-
61	Ubiquitination	VKGIPEDKNPFKEKG CCCCCCCCCCCCCCC	65.93	-
70	Methylation	PFKEKGSCVIS---- CCCCCCCCCCC----	4.25	-
70	Farnesylation	PFKEKGSCVIS---- CCCCCCCCCCC----	4.25	7665596
70	Farnesylation	PFKEKGSCVIS---- CCCCCCCCCCC----	4.25	7665596

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBG11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBG11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBG11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AMOL2_HUMAN	AMOTL2	physical	16189514
ZHX1_HUMAN	ZHX1	physical	16169070
GBB1_HUMAN	GNB1	physical	19168127
GBB3_HUMAN	GNB3	physical	19168127
MEOX2_HUMAN	MEOX2	physical	25416956
CEP44_HUMAN	CEP44	physical	25416956
PHLP_HUMAN	PDCL	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Prenylation

"Isolation of cDNA clones encoding eight different human G proteingamma subunits, including three novel forms designated the gamma 4,gamma 10, and gamma 11 subunits.";
Ray K., Kunsch C., Bonner L.M., Robishaw J.D.;
J. Biol. Chem. 270:21765-21771(1995).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], AND ISOPRENYLATION AT CYS-70.
PubMed: 7665596