GBB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBB3_HUMAN
• UniProt AC: P16520
• Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
• Gene Name: GNB3
• Organism: Homo sapiens (Human).
• Sequence Length: 340
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
• Protein Sequence: MGEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Acetylation	QEAEQLKKQIADARK HHHHHHHHHHHHHHH	56.37	21466224
23	Acetylation	KQIADARKACADVTL HHHHHHHHHHHHCHH	49.92	21466224
57	Acetylation	TLRGHLAKIYAMHWA HHHHHHHHHHHHHHH	42.48	26051181
59	Phosphorylation	RGHLAKIYAMHWATD HHHHHHHHHHHHHCC	9.36	-
68	Acetylation	MHWATDSKLLVSASQ HHHHCCCCEEEEECC	48.96	19413330
72	Phosphorylation	TDSKLLVSASQDGKL CCCCEEEEECCCCCE	23.36	-
74	Phosphorylation	SKLLVSASQDGKLIV CCEEEEECCCCCEEE	22.69	19060867
78	Acetylation	VSASQDGKLIVWDSY EEECCCCCEEEEEEC	43.24	30588975
85	Phosphorylation	KLIVWDSYTTNKVHA CEEEEEECCCCEEEE	18.34	19413330
86	Phosphorylation	LIVWDSYTTNKVHAI EEEEEECCCCEEEEE	28.04	19413330
87	Phosphorylation	IVWDSYTTNKVHAIP EEEEECCCCEEEEEE	25.47	19413330
89	Ubiquitination	WDSYTTNKVHAIPLR EEECCCCEEEEEECC	33.05	21906983
89	Acetylation	WDSYTTNKVHAIPLR EEECCCCEEEEEECC	33.05	26051181
129	ADP-ribosylation	SIYNLKSREGNVKVS EEEECCCCCCCCEEC	55.01	-
140	Phosphorylation	VKVSRELSAHTGYLS CEECHHHHHCCCEEE	17.16	22461510
143	Phosphorylation	SRELSAHTGYLSCCR CHHHHHCCCEEEEEE	27.52	22461510
145	Phosphorylation	ELSAHTGYLSCCRFL HHHHCCCEEEEEEEE	9.15	22461510
177	Ubiquitination	DIETGQQKTVFVGHT EECCCCEEEEEEECC	38.48	-
207	Phosphorylation	ISGACDASAKLWDVR EECCCCCCCCEEEEC	16.82	22817900
209	Acetylation	GACDASAKLWDVREG CCCCCCCCEEEECCC	47.84	26051181
309	Phosphorylation	SERVGILSGHDNRVS CCCEEEEECCCCCEE	31.96	-
334	Phosphorylation	VATGSWDSFLKIWN- EEECCHHHHHHHCC-	26.64	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PHLP_HUMAN	PDCL	physical	19376773
GBG2_HUMAN	GNG2	physical	19376773
GBG2_HUMAN	GNG2	physical	22940628
GBG5_HUMAN	GNG5	physical	22940628
GBG8_HUMAN	GNG8	physical	22940628
GBG10_HUMAN	GNG10	physical	22940628
GBG12_HUMAN	GNG12	physical	22940628
GNAI3_HUMAN	GNAI3	physical	22940628
GNAQ_HUMAN	GNAQ	physical	22940628
GNA12_HUMAN	GNA12	physical	22940628
GBB3_HUMAN	GNB3	physical	21125662

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.