GNA12_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNA12_HUMAN
• UniProt AC: Q03113
• Protein Name: Guanine nucleotide-binding protein subunit alpha-12
• Gene Name: GNA12
• Organism: Homo sapiens (Human).
• Sequence Length: 381
• Subcellular Localization: Cell membrane ; Lipid-anchor . Lateral cell membrane ; Lipid-anchor . Cytoplasm . CDH1 enhances cell membrane localization.
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. [PubMed: 22609986]
• Protein Sequence: MSGVVRTLSRCLLPAEAGGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQYSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKTVSIKKHFPDFRGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENVRFVFHAVKDTILQENLKDIMLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	S-palmitoylation	VVRTLSRCLLPAEAG HHHHHHHHCCCHHHC	4.04	-
40	Phosphorylation	EREARRRSRDIDALL HHHHHHHHHHHHHHH	32.28	22777824
68	Phosphorylation	LLLGAGESGKSTFLK HHHCCCCCCHHHHHH	51.07	20068231
70	Ubiquitination	LGAGESGKSTFLKQM HCCCCCCHHHHHHHC	56.45	-
75	Ubiquitination	SGKSTFLKQMRIIHG CCHHHHHHHCHHHCC	37.55	-
105	Ubiquitination	FDNILKGSRVLVDAR HHHHHCCCEEEEECH	20.03	21906983
114	Ubiquitination	VLVDARDKLGIPWQY EEEECHHHHCCCCCC	42.96	-
121	Phosphorylation	KLGIPWQYSENEKHG HHCCCCCCCCCCCCC	17.68	-
139	Ubiquitination	MAFENKAGLPVEPAT EEEECCCCCCCCCCE	31.93	-
161	Ubiquitination	LSALWRDSGIREAFS HHHHHHHHCHHHHHH	27.78	-
198	Ubiquitination	QLNYFPSKQDILLAR CCCCCCCHHHHHHHH	52.83	21906983
208	Phosphorylation	ILLARKATKGIVEHD HHHHHHCCCCCCCCC	32.60	-
219	Ubiquitination	VEHDFVIKKIPFKMV CCCCEEEEECCCEEE	39.07	-
220	Ubiquitination	EHDFVIKKIPFKMVD CCCEEEEECCCEEEE	44.48	-
235	Methylation	VGGQRSQRQKWFQCF CCCCCCHHHHHHHHH	41.09	-
283	Ubiquitination	IFETIVNNKLFFNVS HHHHHHHCCCCCCHH	31.36	21906983
317	Ubiquitination	IKKHFPDFRGDPHRL HHHHCCCCCCCHHHH	10.81	-
343	Phosphorylation	DRKRRNRSKPLFHHF HHCCCCCCCCCCCCC	42.02	24719451
369	Phosphorylation	VFHAVKDTILQENLK HHHHHHHHHHHHHHH	20.19	25332170
376	Ubiquitination	TILQENLKDIMLQ-- HHHHHHHHHHHCC--	57.71	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNA12_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNA12_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNA12_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAD15_HUMAN	CDH15	physical	11136230
PPP5_HUMAN	PPP5C	physical	12176367
ARHGC_HUMAN	ARHGEF12	physical	11094164
PAR1_HUMAN	F2R	physical	8290554
TA2R_HUMAN	TBXA2R	physical	8290554
HS90A_HUMAN	HSP90AA1	physical	11598136
ARHGB_HUMAN	ARHGEF11	physical	10026210
M3K5_HUMAN	MAP3K5	physical	17595347
ARG28_HUMAN	ARHGEF28	physical	17595347
A4_HUMAN	APP	physical	21832049
IL3RA_HUMAN	IL3RA	physical	21988832

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.