CAD15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAD15_HUMAN
• UniProt AC: P55291
• Protein Name: Cadherin-15
• Gene Name: CDH15
• Organism: Homo sapiens (Human).
• Sequence Length: 814
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation..
• Protein Sequence: MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYGHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	WRRAPALSRVRRAWV CCCCCHHHHCCEEEE	30.73	23403867
227	N-linked_Glycosylation	REVVAVYNLTLQVAD HHHEEEEEEEEEEEC	21.68	UniProtKB CARBOHYD
310	Phosphorylation	GDPDGQFTIRTDPKT CCCCCCEEEEECCCC	11.14	24719451
330	Phosphorylation	SIVKALDYESCEHYE HHEEECCHHHCCEEE	15.59	-
336	Phosphorylation	DYESCEHYELKVSVQ CHHHCCEEEEEEEEC	10.72	-
441	Phosphorylation	QHVLSPASPFLKGGW EEECCCCCCCCCCCE	21.40	24719451
531	N-linked_Glycosylation	RLPELGRNWSLSQVN CCCCCCCCCCHHHCC	30.78	UniProtKB CARBOHYD
538	N-linked_Glycosylation	NWSLSQVNVSHARLR CCCHHHCCCCCCCCC	23.18	UniProtKB CARBOHYD
576	N-linked_Glycosylation	QQREQPLNVTVCRCG CCCCCCCEEEEEECC	33.81	UniProtKB CARBOHYD
632	Ubiquitination	ALRARFWKQSRGKGL HHHHHHHHHHCCCCC	35.37	22817900
637	Ubiquitination	FWKQSRGKGLLHGPQ HHHHHCCCCCCCCCC	45.32	21906983
801	Phosphorylation	HQAREGLSPGALLPR HHHCCCCCCCCCCCC	31.95	32142685

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAD15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAD15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAD15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARVC_HUMAN	ARVCF	physical	11058098
CTNB1_MOUSE	Ctnnb1	physical	9545347
SGTA_HUMAN	SGTA	physical	25416956

Drug and Disease Associations

• Kegg Disease
• H00773: Non-syndromic autosomal dominant mental retardation
• OMIM Disease
• : Note=A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11
• : 16)(q24.2
• : q24).
• 612580:
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.