IL3RA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IL3RA_HUMAN
• UniProt AC: P26951
• Protein Name: Interleukin-3 receptor subunit alpha
• Gene Name: IL3RA
• Organism: Homo sapiens (Human).
• Sequence Length: 378
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: This is a receptor for interleukin-3..
• Protein Sequence: MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	N-linked_Glycosylation	LTWDLNRNVTDIECV HHEECCCCCCCEEEE	39.71	UniProtKB CARBOHYD
64	N-linked_Glycosylation	DYSMPAVNNSYCQFG CCCCCCCCCCCCCCC	33.56	UniProtKB CARBOHYD
80	N-linked_Glycosylation	ISLCEVTNYTVRVAN EEEEEECCCEEEECC	35.34	UniProtKB CARBOHYD
109	N-linked_Glycosylation	KPWAGAENLTCWIHD CCCCCCCCCEEEEEE	39.87	UniProtKB CARBOHYD
174	Phosphorylation	FDDISRLSSGSQSSH ECHHHHCCCCCCCCC	31.38	22210691
175	Phosphorylation	DDISRLSSGSQSSHI CHHHHCCCCCCCCCE	47.24	-
212	N-linked_Glycosylation	IEILTPPNMTAKCNK EEEECCCCCCCCCCC	41.46	UniProtKB CARBOHYD
218	N-linked_Glycosylation	PNMTAKCNKTHSFMH CCCCCCCCCCCCCHH	52.10	UniProtKB CARBOHYD
238	Phosphorylation	HFNRKFRYELQIQKR HHCHHHHHHHHHHHH	24.91	-
306	Phosphorylation	ANTRAWRTSLLIALG CCCHHHHHHHHHHHH	17.02	27542207
307	Phosphorylation	NTRAWRTSLLIALGT CCHHHHHHHHHHHHH	16.77	27542207
314	Phosphorylation	SLLIALGTLLALVCV HHHHHHHHHHHHHHH	21.32	27542207
328	Phosphorylation	VFVICRRYLVMQRLF HHHHHHHHHHHHHHC	5.58	-
348	Phosphorylation	MKDPIGDSFQNDKLV CCCCCCCCCCCCCEE	24.42	23401153

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IL3RA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IL3RA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IL3RA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LNX1_HUMAN	LNX1	physical	21988832
SGK2_HUMAN	SGK2	physical	21988832
NR0B2_HUMAN	NR0B2	physical	21988832
SAE1_HUMAN	SAE1	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.