dbPTM

SGK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SGK2_HUMAN
UniProt AC	Q9HBY8
Protein Name	Serine/threonine-protein kinase Sgk2
Gene Name	SGK2
Organism	Homo sapiens (Human).
Sequence Length	427
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase..
Protein Sequence	MQGLLTSGRKPSGGGRCTGRGGWRGQWCLKPWMGGADPPTPTLSCLLLPVPPELPDHCYRMNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 2)	Phosphorylation	-	36.07	29116813
10	Phosphorylation	GLLTSGRKPSGGGRC CCCCCCCCCCCCCCC	47.24	-
10 (in isoform 2)	Phosphorylation	-	47.24	29116813
63	Phosphorylation	DHCYRMNSSPAGTPS CCCCCCCCCCCCCCC	28.49	25841592
64	Phosphorylation	HCYRMNSSPAGTPSP CCCCCCCCCCCCCCC	17.48	25841592
64	Ubiquitination	HCYRMNSSPAGTPSP CCCCCCCCCCCCCCC	17.48	21890473
68	Phosphorylation	MNSSPAGTPSPQPSR CCCCCCCCCCCCCCC	23.77	28857561
70	Phosphorylation	SSPAGTPSPQPSRAN CCCCCCCCCCCCCCC	35.68	28857561
74	Phosphorylation	GTPSPQPSRANGNIN CCCCCCCCCCCCCCC	38.48	25841592
99	Ubiquitination	PTDFDFLKVIGKGNY CCCCCEEEEECCCCC	31.62	-
116	Phosphorylation	VLLAKRKSDGAFYAV EEEEEECCCCCEEHH	45.36	28857561
121	Phosphorylation	RKSDGAFYAVKVLQK ECCCCCEEHHHHHHH	15.22	23312004
124	Ubiquitination	DGAFYAVKVLQKKSI CCCEEHHHHHHHHHH	29.11	21890473
130	Phosphorylation	VKVLQKKSILKKKEQ HHHHHHHHHHCHHHH	39.94	24719451
193	Phosphorylation	QRERRFLEPRARFYA HHHHCCCCHHHHHHH	29.99	10548550
251	Phosphorylation	GVEPEDTTSTFCGTP CCCCCCCCCCCCCCH	37.78	22322096
253	Phosphorylation	EPEDTTSTFCGTPEY CCCCCCCCCCCCHHH	22.35	22322096
285	Phosphorylation	WCLGAVLYEMLHGLP HHHHHHHHHHHCCCC	7.84	22817900
334	Phosphorylation	SLLHKDQRQRLGSKA HHHCHHHHHHHCCCC	33.45	-
339	Phosphorylation	DQRQRLGSKADFLEI HHHHHHCCCCHHHEE	29.30	23312004
356	Phosphorylation	HVFFSPINWDDLYHK CEEEECCCHHHHCCC	39.24	-
357	Phosphorylation	VFFSPINWDDLYHKR EEEECCCHHHHCCCC	10.95	-
366	Phosphorylation	DLYHKRLTPPFNPNV HHCCCCCCCCCCCCC	32.71	24719451
374	Phosphorylation	PPFNPNVTGPADLKH CCCCCCCCCCCCCCC	44.05	24719451
416	Phosphorylation	SSAFLGFSYAPEDDD CCHHCCCCCCCCCCC	20.70	10548550

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
253	T	Phosphorylation	Kinase	PDK1	Q15118	GPS
253	T	Phosphorylation	Kinase	PDK1	O15530	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
193	T	Phosphorylation	10548550
Activated by phosphorylation on Ser-356 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-193.
356	S	Phosphorylation	10548550
Activated by phosphorylation on Ser-356 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-193.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SGK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
TCPG_HUMAN	CCT3	physical	25852190
TCPD_HUMAN	CCT4	physical	25852190
TCPE_HUMAN	CCT5	physical	25852190
TCPZ_HUMAN	CCT6A	physical	25852190
TCPH_HUMAN	CCT7	physical	25852190
TCPQ_HUMAN	CCT8	physical	25852190
DDX5_HUMAN	DDX5	physical	25852190
FKBP5_HUMAN	FKBP5	physical	25852190
ILF3_HUMAN	ILF3	physical	25852190
TCPA_HUMAN	TCP1	physical	25852190

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SGK2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Characterization of the structure and regulation of two novelisoforms of serum- and glucocorticoid-induced protein kinase."; Kobayashi T., Deak M., Morrice N., Cohen P.; Biochem. J. 344:189-197(1999). Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY,PHOSPHORYLATION AT THR-253, AND MUTAGENESIS OF SER-416.	10548550 [Abstract]

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