dbPTM

ARHGC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARHGC_HUMAN
UniProt AC	Q9NZN5
Protein Name	Rho guanine nucleotide exchange factor 12
Gene Name	ARHGEF12
Organism	Homo sapiens (Human).
Sequence Length	1544
Subcellular Localization	Cytoplasm . Membrane . Translocated to the membrane upon stimulation.
Protein Description	May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13..
Protein Sequence	MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNADSPKSGPKERIYLEENPEKSETIQDTDTQSLVGSPSTRIAPHIIGAEDDDFGTEHEQINGQCSCFQSIELLKSRPAHLAVFLHHVVSQFDPATLLCYLYSDLYKHTNSKETRRIFLEFHQFFLDRSAHLKVSVPDEMSADLEKRRPELIPEDLHRHYIQTMQERVHPEVQRHLEDFRQKRSMGLTLAESELTKLDAERDKDRLTLEKERTCAEQIVAKIEEVLMTAQAVEEDKSSTMQYVILMYMKHLGVKVKEPRNLEHKRGRIGFLPKIKQSMKKDKEGEEKGKRRGFPSILGPPRRPSRHDNSAIGRAMELQKARHPKHLSTPSSVSPEPQDSAKLRQSGLANEGTDAGYLPANSMSSVASGASFSQEGGKENDTGSKQVGETSAPGDTLDGTPRTLNTVFDFPPPPLDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLISSKPQSHSLSTSGKSEVRDLFVAERQFAKEQHTDGTLKEVGEDYQIAIPDSHLPVSEERWALDALRNLGLLKQLLVQQLGLTEKSVQEDWQHFPRYRTASQGPQTDSVIQNSENIKAYHSGEGHMPFRTGTGDIATCYSPRTSTESFAPRDSVGLAPQDSQASNILVMDHMIMTPEMPTMEPEGGLDDSGEHFFDAREAHSDENPSEGDGAVNKEEKDVNLRISGNYLILDGYDPVQESSTDEEVASSLTLQPMTGIPAVESTHQQQHSPQNTHSDGAISPFTPEFLVQQRWGAMEYSCFEIQSPSSCADSQSQIMEYIHKIEADLEHLKKVEESYTILCQRLAGSALTDKHSDKS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGTQSTIT ------CCCCCCCCC	62.95	19413330
2	Phosphorylation	------MSGTQSTIT ------CCCCCCCCC	62.95	25159151
4	Phosphorylation	----MSGTQSTITDR ----CCCCCCCCCCC	28.74	24719451
6	Phosphorylation	--MSGTQSTITDRFP --CCCCCCCCCCCCC	22.93	24043423
7	Phosphorylation	-MSGTQSTITDRFPL -CCCCCCCCCCCCCC	20.34	24043423
9	Phosphorylation	SGTQSTITDRFPLKK CCCCCCCCCCCCCCC	22.62	24719451
11	Methylation	TQSTITDRFPLKKPI CCCCCCCCCCCCCCC	26.82	-
22	Phosphorylation	KKPIRHGSILNRESP CCCCCCCCCCCCCCC	20.13	30266825
28	Phosphorylation	GSILNRESPTDKKQK CCCCCCCCCCCHHHH	29.84	25159151
30	Phosphorylation	ILNRESPTDKKQKVE CCCCCCCCCHHHHHH	70.50	23403867
32	Acetylation	NRESPTDKKQKVERI CCCCCCCHHHHHHHH	60.63	20167786
41	Phosphorylation	QKVERIASHDFDPTD HHHHHHHCCCCCCCC	22.63	29255136
41 (in isoform 2)	Phosphorylation	-	22.63	30266825
47	Phosphorylation	ASHDFDPTDSSSKKT HCCCCCCCCCCCCCC	50.81	23403867
47 (in isoform 2)	Phosphorylation	-	50.81	22199227
49	Phosphorylation	HDFDPTDSSSKKTKS CCCCCCCCCCCCCCC	38.70	23403867
66	Phosphorylation	EESRSEIYGLVQRCV HHHHHHHHHHHCEEE	10.60	25884760
139	Phosphorylation	KLIKSGSYVALTVQG EEEECCCEEEEEECC	8.02	26657352
164	Phosphorylation	ADSEVEPSVIGHMSP CCCCCCCHHHCCCCC	16.92	28348404
170	Phosphorylation	PSVIGHMSPIMTSPH CHHHCCCCCCCCCCC	12.95	28348404
174	Phosphorylation	GHMSPIMTSPHSPGA CCCCCCCCCCCCCCC	39.56	28348404
175	Phosphorylation	HMSPIMTSPHSPGAS CCCCCCCCCCCCCCC	11.84	28348404
178	Phosphorylation	PIMTSPHSPGASGNM CCCCCCCCCCCCCCC	28.54	28348404
182	Phosphorylation	SPHSPGASGNMERIT CCCCCCCCCCCCCCC	36.29	28348404
189	Phosphorylation	SGNMERITSPVLMGE CCCCCCCCCCEECCC	32.95	28102081
190	Phosphorylation	GNMERITSPVLMGEE CCCCCCCCCEECCCC	15.61	25159151
205	Ubiquitination	NNVVHNQKVEILRKM CCCHHHHHHHHHHHH	47.34	-
227	Phosphorylation	LQLLQEDYNRTPAQR HHHHHHHHCCCHHHH	13.04	27642862
230	Phosphorylation	LQEDYNRTPAQRLLK HHHHHCCCHHHHHHH	21.24	28555341
257	Phosphorylation	QEQLSKATGSAQDGA HHHHHHHCCCCCCCC	35.09	27732954
259	Phosphorylation	QLSKATGSAQDGAVV HHHHHCCCCCCCCEE	20.57	27732954
267	Phosphorylation	AQDGAVVTPSRPLGD CCCCCEECCCCCCCC	14.67	25159151
269	Phosphorylation	DGAVVTPSRPLGDTL CCCEECCCCCCCCEE	36.85	27732954
275	Phosphorylation	PSRPLGDTLTVSEAE CCCCCCCEEEEEECC	23.64	27732954
277	Phosphorylation	RPLGDTLTVSEAETD CCCCCEEEEEECCCC	24.87	24905233
279	Phosphorylation	LGDTLTVSEAETDPG CCCEEEEEECCCCCC	26.34	24905233
283	Phosphorylation	LTVSEAETDPGDVLG EEEEECCCCCCCCCC	55.32	27251275
292	Phosphorylation	PGDVLGRTDCSSGDA CCCCCCCCCCCCCCC	39.29	23403867
295	Phosphorylation	VLGRTDCSSGDASRP CCCCCCCCCCCCCCC	39.92	23403867
296	Phosphorylation	LGRTDCSSGDASRPS CCCCCCCCCCCCCCC	47.20	23403867
300	Phosphorylation	DCSSGDASRPSSDNA CCCCCCCCCCCCCCC	49.84	23401153
303	Phosphorylation	SGDASRPSSDNADSP CCCCCCCCCCCCCCC	49.57	25159151
304	Phosphorylation	GDASRPSSDNADSPK CCCCCCCCCCCCCCC	37.25	25159151
309	Phosphorylation	PSSDNADSPKSGPKE CCCCCCCCCCCCCCC	31.64	25159151
312	Phosphorylation	DNADSPKSGPKERIY CCCCCCCCCCCCCEE	64.81	23403867
319	Phosphorylation	SGPKERIYLEENPEK CCCCCCEEEECCCCC	17.81	28674419
327	Phosphorylation	LEENPEKSETIQDTD EECCCCCCCCCCCCC	38.01	23403867
329	Phosphorylation	ENPEKSETIQDTDTQ CCCCCCCCCCCCCHH	30.91	23403867
333	Phosphorylation	KSETIQDTDTQSLVG CCCCCCCCCHHHHCC	25.27	23403867
335	Phosphorylation	ETIQDTDTQSLVGSP CCCCCCCHHHHCCCC	23.34	25159151
337	Phosphorylation	IQDTDTQSLVGSPST CCCCCHHHHCCCCCC	27.41	25159151
341	Phosphorylation	DTQSLVGSPSTRIAP CHHHHCCCCCCCCCC	14.27	25159151
343	Phosphorylation	QSLVGSPSTRIAPHI HHHCCCCCCCCCCEE	31.83	25159151
344	Phosphorylation	SLVGSPSTRIAPHII HHCCCCCCCCCCEEC	29.49	25159151
488	Phosphorylation	EDFRQKRSMGLTLAE HHHHHHHHHCCCHHH	25.00	28857561
532	Phosphorylation	KIEEVLMTAQAVEED HHHHHHHHHHHHHCC	16.08	-
541	Phosphorylation	QAVEEDKSSTMQYVI HHHHCCCCHHHHHHH	43.28	24173317
542	Phosphorylation	AVEEDKSSTMQYVIL HHHCCCCHHHHHHHH	33.37	24173317
543	Phosphorylation	VEEDKSSTMQYVILM HHCCCCHHHHHHHHH	18.51	24173317
546	Phosphorylation	DKSSTMQYVILMYMK CCCHHHHHHHHHHHH	4.42	18491316
581	Phosphorylation	FLPKIKQSMKKDKEG CHHHHHHHHHCCCCC	27.80	23403867
584	Acetylation	KIKQSMKKDKEGEEK HHHHHHHCCCCCHHC	66.45	22424773
586	Acetylation	KQSMKKDKEGEEKGK HHHHHCCCCCHHCHH	76.21	22424773
591	Acetylation	KDKEGEEKGKRRGFP CCCCCHHCHHHCCCC	66.48	22424773
593	Acetylation	KEGEEKGKRRGFPSI CCCHHCHHHCCCCHH	50.41	22424773
599	Phosphorylation	GKRRGFPSILGPPRR HHHCCCCHHCCCCCC	28.34	28152594
608	Phosphorylation	LGPPRRPSRHDNSAI CCCCCCCCCCCCCHH	40.20	27794612
613	Phosphorylation	RPSRHDNSAIGRAME CCCCCCCCHHHHHHH	27.59	23312004
617	Methylation	HDNSAIGRAMELQKA CCCCHHHHHHHHHHH	25.34	-
631	Phosphorylation	ARHPKHLSTPSSVSP HCCCCCCCCCCCCCC	37.68	23927012
632	Phosphorylation	RHPKHLSTPSSVSPE CCCCCCCCCCCCCCC	33.28	25159151
634	Phosphorylation	PKHLSTPSSVSPEPQ CCCCCCCCCCCCCCC	43.38	23927012
635	Phosphorylation	KHLSTPSSVSPEPQD CCCCCCCCCCCCCCC	28.02	23927012
637	Phosphorylation	LSTPSSVSPEPQDSA CCCCCCCCCCCCCHH	26.03	29255136
643	Phosphorylation	VSPEPQDSAKLRQSG CCCCCCCHHHHHHCC	23.27	23403867
660	Phosphorylation	NEGTDAGYLPANSMS CCCCCCCCCCCCCCC	15.95	27259358
667	Phosphorylation	YLPANSMSSVASGAS CCCCCCCCCHHCCCC	22.83	27251275
668	Phosphorylation	LPANSMSSVASGASF CCCCCCCCHHCCCCC	17.04	27251275
671	Phosphorylation	NSMSSVASGASFSQE CCCCCHHCCCCCCCC	32.51	27251275
693	Phosphorylation	GSKQVGETSAPGDTL CCCCCCCCCCCCCCC	25.02	23403867
694	Phosphorylation	SKQVGETSAPGDTLD CCCCCCCCCCCCCCC	28.32	23403867
699	Phosphorylation	ETSAPGDTLDGTPRT CCCCCCCCCCCCCCC	32.44	26657352
703	Phosphorylation	PGDTLDGTPRTLNTV CCCCCCCCCCCCCCC	14.84	28355574
732	Phosphorylation	ECEVERVTEHGTPKP HCEEEEECCCCCCCC	28.61	30266825
736	Phosphorylation	ERVTEHGTPKPFRKF EEECCCCCCCCCCCC	30.01	23401153
745	Phosphorylation	KPFRKFDSVAFGESQ CCCCCCCCEEECCCC	20.62	28122231
751	Phosphorylation	DSVAFGESQSEDEQF CCEEECCCCCCCHHH	39.11	25921289
753	Phosphorylation	VAFGESQSEDEQFEN EEECCCCCCCHHHCH	57.18	25921289
764	Phosphorylation	QFENDLETDPPNWQQ HHCHHCCCCCCCHHH	62.19	22210691
818	Phosphorylation	QVFYQRVSREGILSP HHHHHHHCCCCCCCH	27.14	-
824	Phosphorylation	VSREGILSPSELRKI HCCCCCCCHHHHHHH	25.18	21815630
826	Phosphorylation	REGILSPSELRKIFS CCCCCCHHHHHHHHH	45.98	-
829	Methylation	ILSPSELRKIFSNLE CCCHHHHHHHHHCHH	26.44	-
910	Phosphorylation	KKDSRFQTFVQDAES CCCCCHHHHHHHHHC	24.06	28857561
950	Phosphorylation	LLDNIAKYTEWPTER HHHHHHHHCCCCCHH	10.81	28509920
951	Phosphorylation	LDNIAKYTEWPTERE HHHHHHHCCCCCHHH	30.76	28509920
955	Phosphorylation	AKYTEWPTEREKVKK HHHCCCCCHHHHHHH	49.07	28509920
990	Phosphorylation	NKQRLEDYQRRLDTS HHHHHHHHHHHHCCC	8.44	26029660
996	Phosphorylation	DYQRRLDTSSLKLSE HHHHHHCCCCCCHHC	25.47	26029660
997	Phosphorylation	YQRRLDTSSLKLSEY HHHHHCCCCCCHHCC	33.08	26029660
998	Phosphorylation	QRRLDTSSLKLSEYP HHHHCCCCCCHHCCC	31.45	26029660
1000	Ubiquitination	RLDTSSLKLSEYPNV HHCCCCCCHHCCCCH	52.49	-
1002	Phosphorylation	DTSSLKLSEYPNVEE CCCCCCHHCCCCHHH	33.23	28122231
1004	Phosphorylation	SSLKLSEYPNVEELR CCCCHHCCCCHHHHH	9.20	27642862
1017	Ubiquitination	LRNLDLTKRKMIHEG HHCCCCCCCCCCCCC	58.27	-
1039	Phosphorylation	RDKTIDLYTLLLEDI CCCCCHHHHHHHHHH	7.50	30576142
1064	Ubiquitination	LVLRCHSKILASTAD HHHEECCHHHHHHCC	20.34	-
1068	Phosphorylation	CHSKILASTADSKHT ECCHHHHHHCCCCCC	22.23	23403867
1069	Phosphorylation	HSKILASTADSKHTF CCHHHHHHCCCCCCC	28.95	23403867
1072	Phosphorylation	ILASTADSKHTFSPV HHHHHCCCCCCCCCC	24.71	-
1077	Phosphorylation	ADSKHTFSPVIKLST CCCCCCCCCCHHHHH	21.29	24260401
1147	Phosphorylation	KPIPLPQSTPGEGDN CCCCCCCCCCCCCCC	34.33	25627689
1148	Phosphorylation	PIPLPQSTPGEGDND CCCCCCCCCCCCCCC	30.02	25159151
1160	Phosphorylation	DNDEEDPSKLKEEQH CCCCCCHHHHHHHHH	64.04	27732954
1170	Phosphorylation	KEEQHGISVTGLQSP HHHHHCCEECCCCCC	20.44	29978859
1172	Phosphorylation	EQHGISVTGLQSPDR HHHCCEECCCCCCCC	25.94	30576142
1176	Phosphorylation	ISVTGLQSPDRDLGL CEECCCCCCCCCCCC	33.54	29255136
1185	Phosphorylation	DRDLGLESTLISSKP CCCCCCCCEECCCCC	33.29	26074081
1186	Phosphorylation	RDLGLESTLISSKPQ CCCCCCCEECCCCCC	20.80	26074081
1189	Phosphorylation	GLESTLISSKPQSHS CCCCEECCCCCCCCC	35.11	26074081
1190	Phosphorylation	LESTLISSKPQSHSL CCCEECCCCCCCCCC	41.16	26074081
1194	Phosphorylation	LISSKPQSHSLSTSG ECCCCCCCCCCCCCC	24.46	23312004
1196	Phosphorylation	SSKPQSHSLSTSGKS CCCCCCCCCCCCCCH	29.30	23312004
1198	Phosphorylation	KPQSHSLSTSGKSEV CCCCCCCCCCCCHHH	24.44	28857561
1199	Phosphorylation	PQSHSLSTSGKSEVR CCCCCCCCCCCHHHH	46.95	23312004
1200	Phosphorylation	QSHSLSTSGKSEVRD CCCCCCCCCCHHHHH	40.63	23312004
1203	Phosphorylation	SLSTSGKSEVRDLFV CCCCCCCHHHHHHHH	44.86	23312004
1232	Phosphorylation	LKEVGEDYQIAIPDS HHHCCCCEEEECCCC	9.49	28796482
1239	Phosphorylation	YQIAIPDSHLPVSEE EEEECCCCCCCCCHH	22.90	-
1273	Phosphorylation	QLGLTEKSVQEDWQH HHCCCHHHHHHHHHC	23.85	22199227
1284	Phosphorylation	DWQHFPRYRTASQGP HHHCCCCCCCCCCCC	16.74	30183078
1286	Phosphorylation	QHFPRYRTASQGPQT HCCCCCCCCCCCCCC	23.02	29255136
1288	Phosphorylation	FPRYRTASQGPQTDS CCCCCCCCCCCCCCH	34.75	29255136
1293	Phosphorylation	TASQGPQTDSVIQNS CCCCCCCCCHHHCCC	33.12	30278072
1295	Phosphorylation	SQGPQTDSVIQNSEN CCCCCCCHHHCCCCC	25.22	23911959
1300	Phosphorylation	TDSVIQNSENIKAYH CCHHHCCCCCCEEEE	18.69	23403867
1308	Phosphorylation	ENIKAYHSGEGHMPF CCCEEEECCCCCCCC	26.34	25159151
1319	Phosphorylation	HMPFRTGTGDIATCY CCCCCCCCCCEEEEE	30.94	21945579
1324	Phosphorylation	TGTGDIATCYSPRTS CCCCCEEEEECCCCC	16.59	21945579
1326	Phosphorylation	TGDIATCYSPRTSTE CCCEEEEECCCCCCC	19.84	21945579
1327	Phosphorylation	GDIATCYSPRTSTES CCEEEEECCCCCCCC	15.28	21945579
1330	Phosphorylation	ATCYSPRTSTESFAP EEEECCCCCCCCCCC	43.30	30278072
1331	O-linked_Glycosylation	TCYSPRTSTESFAPR EEECCCCCCCCCCCC	31.30	30379171
1331	Phosphorylation	TCYSPRTSTESFAPR EEECCCCCCCCCCCC	31.30	22985185
1332	Phosphorylation	CYSPRTSTESFAPRD EECCCCCCCCCCCCC	34.73	26699800
1334	Phosphorylation	SPRTSTESFAPRDSV CCCCCCCCCCCCCCC	27.14	26699800
1377	Phosphorylation	PEGGLDDSGEHFFDA CCCCCCCCCCCCCCH	45.83	28348404
1389	Phosphorylation	FDAREAHSDENPSEG CCHHHHCCCCCCCCC	54.38	23401153
1394	Phosphorylation	AHSDENPSEGDGAVN HCCCCCCCCCCCCCC	66.83	28192239
1415	Phosphorylation	NLRISGNYLILDGYD EEEEECCEEEEECCC	9.92	24275569
1436	Phosphorylation	TDEEVASSLTLQPMT CCHHHHHHCCCCCCC	18.68	26074081
1438	Phosphorylation	EEVASSLTLQPMTGI HHHHHHCCCCCCCCC	25.87	26074081
1443	Phosphorylation	SLTLQPMTGIPAVES HCCCCCCCCCCCCCC	38.35	26074081
1450	Phosphorylation	TGIPAVESTHQQQHS CCCCCCCCCCCCCCC	25.29	26657352
1451	Phosphorylation	GIPAVESTHQQQHSP CCCCCCCCCCCCCCC	15.36	26074081
1457	Phosphorylation	STHQQQHSPQNTHSD CCCCCCCCCCCCCCC	24.68	26657352
1461	Phosphorylation	QQHSPQNTHSDGAIS CCCCCCCCCCCCCCC	19.94	26074081
1463	Phosphorylation	HSPQNTHSDGAISPF CCCCCCCCCCCCCCC	35.38	26074081
1468	Phosphorylation	THSDGAISPFTPEFL CCCCCCCCCCCHHHH	17.27	26657352
1492	Phosphorylation	YSCFEIQSPSSCADS EEEEEECCCCCCCCC	32.20	27251275
1499	Phosphorylation	SPSSCADSQSQIMEY CCCCCCCCHHHHHHH	17.13	26074081
1501	Phosphorylation	SSCADSQSQIMEYIH CCCCCCHHHHHHHHH	26.14	26074081
1506	Phosphorylation	SQSQIMEYIHKIEAD CHHHHHHHHHHHHHH	7.31	26074081
1524	Phosphorylation	LKKVEESYTILCQRL HHHHHHHHHHHHHHH	10.90	-
1525	Phosphorylation	KKVEESYTILCQRLA HHHHHHHHHHHHHHH	19.42	-
1537	Phosphorylation	RLAGSALTDKHSDKS HHHCCCCCCCCCCCC	42.59	23403867
1541	Phosphorylation	SALTDKHSDKS---- CCCCCCCCCCC----	53.10	30266825
1544	Phosphorylation	TDKHSDKS------- CCCCCCCC-------	50.90	20363803

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARHGC_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARHGC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARHGC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARHGC_HUMAN	ARHGEF12	physical	14712228
PLXB2_HUMAN	PLXNB2	physical	12183458
PLXB1_HUMAN	PLXNB1	physical	12220504
GNA12_HUMAN	GNA12	genetic	12515866
GNA13_HUMAN	GNA13	genetic	12515866
CUL3_HUMAN	CUL3	physical	21670212
RHOA_HUMAN	RHOA	physical	23405219

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARHGC_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1286 AND SER-1327, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-341, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-41, AND MASSSPECTROMETRY.	18220336 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1288, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-736, AND MASSSPECTROMETRY.	18088087 [Abstract]