| UniProt ID | ARG28_HUMAN | |
|---|---|---|
| UniProt AC | Q8N1W1 | |
| Protein Name | Rho guanine nucleotide exchange factor 28 | |
| Gene Name | ARHGEF28 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1705 | |
| Subcellular Localization | Cytoplasm. Cell membrane. Colocalizes with the microtubule radial and cortical systems.. | |
| Protein Description | Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).. | |
| Protein Sequence | MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVPGHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLTPFALTAGALPALDEELVLALTHLELPLEWTVLGSSSLEVSSHRESLLHLAMRWGLAKLSQFFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLSEEASLHYIHSSETLTLTLNHTAEHLLEADIKLFRKYFWDRAFLVKAFEPEARPEERTAMPSSGAETEEEIKNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHSLDLDRSFDILKKSKPPSTLLAAGRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITATTSPESRGCTLWPQSSKHTLPTETSPSVYPLSENVEGTAHTEAQQSFMSPSSSCASNLNLSFGWHGFEKEQSHLKKRSSSLDALDADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNISRAESLPLSSNLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVCSSSEEQRAYSLSEPPRENRIQEEEWDKYIIPAKSESEKYKVSRTFSFLMNRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTKKFQEKYNKNKPQTILGNSSFRDIPQPGLSLHPSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLIKPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPGSPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLPGGPEVMELNRSESLCHENSFFINEALVQMSFNTFNKLNPSVIHQDATYPTTQSHSDLVRTSEHQVDLKVDPSQPSNVSHKLWTAAGSGHQILPFHESSKDSCKNDLDTSHTESPTPHDSNSHRPQLQAFITEAKLNLPTRTMTRQDGETGDGAKENIVYL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MELSCSEAPLY ----CCCCCCCCCCC | - | ||
| 6 | Phosphorylation | --MELSCSEAPLYGQ --CCCCCCCCCCCCC | - | ||
| 11 | Phosphorylation | SCSEAPLYGQMMIYA CCCCCCCCCCEEEEE | - | ||
| 31 (in isoform 5) | Phosphorylation | - | 25159151 | ||
| 105 | Phosphorylation | RLARLLVTQANRLTA HHHHHHHHHHHHHHH | 29449344 | ||
| 150 | Phosphorylation | LELPLEWTVLGSSSL CCCCEEEEECCCCEE | 22468782 | ||
| 156 | Phosphorylation | WTVLGSSSLEVSSHR EEECCCCEEEEHHCH | 22468782 | ||
| 213 | Ubiquitination | ALREGHSKLVEDVTN HHHCCCHHHHHCHHC | - | ||
| 248 | Phosphorylation | HYIHSSETLTLTLNH EEECCCCEEEEEECC | 33259812 | ||
| 292 | Ubiquitination | EARPEERTAMPSSGA CCCHHHCCCCCCCCC | 29967540 | ||
| 297 | Phosphorylation | ERTAMPSSGAETEEE HCCCCCCCCCCCHHH | 21815630 | ||
| 313 | Phosphorylation | KNSVSSRSAAEKEDI HHHHHCCCHHHHHHH | - | ||
| 325 | Phosphorylation | EDIKRVKSLVVQHNE HHHHHHHHHHCCCCC | 27422710 | ||
| 325 (in isoform 6) | Phosphorylation | - | 27251275 | ||
| 338 | Phosphorylation | NEHEDQHSLDLDRSF CCCCCHHCCCCHHHH | 29496963 | ||
| 338 (in isoform 6) | Phosphorylation | - | 27251275 | ||
| 344 | Phosphorylation | HSLDLDRSFDILKKS HCCCCHHHHHHHHHC | 21815630 | ||
| 349 | Ubiquitination | DRSFDILKKSKPPST HHHHHHHHHCCCHHH | 29967540 | ||
| 351 | Phosphorylation | SFDILKKSKPPSTLL HHHHHHHCCCHHHHH | 29457462 | ||
| 355 | Phosphorylation | LKKSKPPSTLLAAGR HHHCCCHHHHHHHHC | 29457462 | ||
| 356 | Phosphorylation | KKSKPPSTLLAAGRL HHCCCHHHHHHHHCH | 29457462 | ||
| 413 | Phosphorylation | GCTLWPQSSKHTLPT CCCCCCCCCCCCCCC | - | ||
| 414 | Phosphorylation | CTLWPQSSKHTLPTE CCCCCCCCCCCCCCC | - | ||
| 445 | Phosphorylation | HTEAQQSFMSPSSSC CHHHHHHHCCCCHHH | 32645325 | ||
| 476 | Phosphorylation | QSHLKKRSSSLDALD HHHHHHCCCCCCCCC | 23663014 | ||
| 476 (in isoform 6) | Phosphorylation | - | 24719451 | ||
| 477 | Phosphorylation | SHLKKRSSSLDALDA HHHHHCCCCCCCCCC | 23663014 | ||
| 478 | Phosphorylation | HLKKRSSSLDALDAD HHHHCCCCCCCCCCC | 23663014 | ||
| 478 (in isoform 6) | Phosphorylation | - | 27251275 | ||
| 486 | Phosphorylation | LDALDADSEGEGHSE CCCCCCCCCCCCCCC | 25159151 | ||
| 486 (in isoform 6) | Phosphorylation | - | 24719451 | ||
| 492 | Phosphorylation | DSEGEGHSEPSHICY CCCCCCCCCCCCEEE | 23663014 | ||
| 495 | Phosphorylation | GEGHSEPSHICYTPG CCCCCCCCCEEECCC | 23663014 | ||
| 499 | Phosphorylation | SEPSHICYTPGSQSS CCCCCEEECCCCCCC | 23663014 | ||
| 500 | Phosphorylation | EPSHICYTPGSQSSS CCCCEEECCCCCCCC | 23663014 | ||
| 503 | Phosphorylation | HICYTPGSQSSSRTG CEEECCCCCCCCCCC | 27732954 | ||
| 505 | Phosphorylation | CYTPGSQSSSRTGIP EECCCCCCCCCCCCC | 27732954 | ||
| 506 | Phosphorylation | YTPGSQSSSRTGIPS ECCCCCCCCCCCCCC | 27732954 | ||
| 507 | Phosphorylation | TPGSQSSSRTGIPSG CCCCCCCCCCCCCCC | 27732954 | ||
| 509 | Phosphorylation | GSQSSSRTGIPSGDE CCCCCCCCCCCCCCC | 23403867 | ||
| 513 | Phosphorylation | SSRTGIPSGDELDSF CCCCCCCCCCCCCCC | 26657352 | ||
| 513 (in isoform 6) | Phosphorylation | - | 24719451 | ||
| 519 | Phosphorylation | PSGDELDSFETNTEP CCCCCCCCCCCCCCC | 23403867 | ||
| 522 | Phosphorylation | DELDSFETNTEPDFN CCCCCCCCCCCCCCC | 23403867 | ||
| 524 | Phosphorylation | LDSFETNTEPDFNIS CCCCCCCCCCCCCCC | 23403867 | ||
| 531 | Phosphorylation | TEPDFNISRAESLPL CCCCCCCCHHHHCCC | 27732954 | ||
| 535 | Phosphorylation | FNISRAESLPLSSNL CCCCHHHHCCCCCCC | 30266825 | ||
| 535 (in isoform 6) | Phosphorylation | - | 24719451 | ||
| 539 | Phosphorylation | RAESLPLSSNLQSKE HHHHCCCCCCCCCHH | 30266825 | ||
| 540 | Phosphorylation | AESLPLSSNLQSKES HHHCCCCCCCCCHHH | 30266825 | ||
| 544 | Phosphorylation | PLSSNLQSKESLLSG CCCCCCCCHHHHHHC | 30266825 | ||
| 550 | Phosphorylation | QSKESLLSGVRSRSY CCHHHHHHCCHHCCC | 24719451 | ||
| 554 | Phosphorylation | SLLSGVRSRSYSCSS HHHHCCHHCCCCCCC | 28102081 | ||
| 556 | Phosphorylation | LSGVRSRSYSCSSPK HHCCHHCCCCCCCCC | 23403867 | ||
| 557 | Phosphorylation | SGVRSRSYSCSSPKI HCCHHCCCCCCCCCE | 26657352 | ||
| 558 | Phosphorylation | GVRSRSYSCSSPKIS CCHHCCCCCCCCCEE | 23403867 | ||
| 558 (in isoform 6) | Phosphorylation | - | 24719451 | ||
| 560 | Phosphorylation | RSRSYSCSSPKISLG HHCCCCCCCCCEECC | 23403867 | ||
| 560 | Ubiquitination | RSRSYSCSSPKISLG HHCCCCCCCCCEECC | 24816145 | ||
| 561 | Phosphorylation | SRSYSCSSPKISLGK HCCCCCCCCCEECCC | 23403867 | ||
| 565 | Phosphorylation | SCSSPKISLGKTRLV CCCCCCEECCCCEEE | 26425664 | ||
| 569 | Phosphorylation | PKISLGKTRLVRELT CCEECCCCEEEEEEE | - | ||
| 587 | Phosphorylation | SSEEQRAYSLSEPPR CCHHHHCCCCCCCCC | 28796482 | ||
| 588 | Phosphorylation | SEEQRAYSLSEPPRE CHHHHCCCCCCCCCC | 26657352 | ||
| 590 | Phosphorylation | EQRAYSLSEPPRENR HHHCCCCCCCCCCCC | 25159151 | ||
| 590 (in isoform 6) | Phosphorylation | - | 27251275 | ||
| 605 | Ubiquitination | IQEEEWDKYIIPAKS CCHHHHHHHCEECCC | 29967540 | ||
| 606 (in isoform 6) | Phosphorylation | - | 27642862 | ||
| 611 | Acetylation | DKYIIPAKSESEKYK HHHCEECCCHHHCCC | 12436489 | ||
| 616 | Acetylation | PAKSESEKYKVSRTF ECCCHHHCCCHHHHH | 12436501 | ||
| 618 | Acetylation | KSESEKYKVSRTFSF CCHHHCCCHHHHHHH | 12436513 | ||
| 620 | Phosphorylation | ESEKYKVSRTFSFLM HHHCCCHHHHHHHHH | 29514088 | ||
| 622 | Phosphorylation | EKYKVSRTFSFLMNR HCCCHHHHHHHHHHH | 23403867 | ||
| 624 | Phosphorylation | YKVSRTFSFLMNRMT CCHHHHHHHHHHHCC | 22617229 | ||
| 624 (in isoform 6) | Phosphorylation | - | 24719451 | ||
| 692 | Ubiquitination | NANVHKGCKDAAPAC CCCCCCCCCCHHHHH | 24816145 | ||
| 693 | Acetylation | ANVHKGCKDAAPACT CCCCCCCCCHHHHHH | 7704439 | ||
| 700 | Phosphorylation | KDAAPACTKKFQEKY CCHHHHHHHHHHHHH | - | ||
| 706 | Acetylation | CTKKFQEKYNKNKPQ HHHHHHHHHHCCCCC | 7704451 | ||
| 707 | Phosphorylation | TKKFQEKYNKNKPQT HHHHHHHHHCCCCCE | - | ||
| 714 | Phosphorylation | YNKNKPQTILGNSSF HHCCCCCEECCCCCC | 23312004 | ||
| 719 | Phosphorylation | PQTILGNSSFRDIPQ CCEECCCCCCCCCCC | 23312004 | ||
| 720 | Phosphorylation | QTILGNSSFRDIPQP CEECCCCCCCCCCCC | 23312004 | ||
| 734 | Phosphorylation | PGLSLHPSSSVPVGL CCCCCCCCCCCCCCC | 26699800 | ||
| 734 (in isoform 6) | Phosphorylation | - | 27251275 | ||
| 735 | Phosphorylation | GLSLHPSSSVPVGLP CCCCCCCCCCCCCCC | 26699800 | ||
| 736 | Phosphorylation | LSLHPSSSVPVGLPT CCCCCCCCCCCCCCC | 26657352 | ||
| 740 | Ubiquitination | PSSSVPVGLPTGRRE CCCCCCCCCCCCCCC | 29967540 | ||
| 748 | Phosphorylation | LPTGRRETVGQVHPL CCCCCCCCCCCCEEC | 28555341 | ||
| 748 (in isoform 6) | Phosphorylation | - | 27251275 | ||
| 756 | Phosphorylation | VGQVHPLSRSVPGTT CCCCEECCCCCCCCC | - | ||
| 758 | Phosphorylation | QVHPLSRSVPGTTLE CCEECCCCCCCCCHH | 30266825 | ||
| 758 (in isoform 6) | Phosphorylation | - | 24719451 | ||
| 762 | Phosphorylation | LSRSVPGTTLESFRR CCCCCCCCCHHHHHH | 30266825 | ||
| 763 | Phosphorylation | SRSVPGTTLESFRRS CCCCCCCCHHHHHHH | 30266825 | ||
| 766 | Phosphorylation | VPGTTLESFRRSATS CCCCCHHHHHHHCHH | 27251275 | ||
| 770 | Phosphorylation | TLESFRRSATSLESE CHHHHHHHCHHCCCC | 28857561 | ||
| 772 | Phosphorylation | ESFRRSATSLESESD HHHHHHCHHCCCCCC | 28450419 | ||
| 773 | Phosphorylation | SFRRSATSLESESDH HHHHHCHHCCCCCCC | 28450419 | ||
| 881 | Ubiquitination | IFRKGMKEELQLDHS HHHHCHHHHHCCCHH | 29967540 | ||
| 907 | Ubiquitination | LLEIHRHFFYSMKER HHHHHHHHHHHHHHH | 24816145 | ||
| 1003 | Ubiquitination | ILLVTQRITKYPVLV HHHHHCHHHCCHHHH | 24816145 | ||
| 1004 | Phosphorylation | LLVTQRITKYPVLVE HHHHCHHHCCHHHHH | - | ||
| 1005 | Ubiquitination | LVTQRITKYPVLVER HHHCHHHCCHHHHHH | 24816145 | ||
| 1006 | Phosphorylation | VTQRITKYPVLVERI HHCHHHCCHHHHHHH | - | ||
| 1048 | Phosphorylation | VDLKVNEYEKNQKWL ECCCCHHHHHHHHHH | 24702127 | ||
| 1053 | Ubiquitination | NEYEKNQKWLEILNK HHHHHHHHHHHHHHH | 29967540 | ||
| 1066 | Phosphorylation | NKIENKTYTKLKNGH HHHCCCCCCCCCCCC | 28509920 | ||
| 1067 | Phosphorylation | KIENKTYTKLKNGHV HHCCCCCCCCCCCCC | 28509920 | ||
| 1086 | Phosphorylation | ALMSEERTLLYDGLV HHHCCCCCHHHCCCC | 29759185 | ||
| 1089 | Phosphorylation | SEERTLLYDGLVYWK CCCCCHHHCCCCCCC | 29759185 | ||
| 1094 | Phosphorylation | LLYDGLVYWKTATGR HHHCCCCCCCCCCCC | 29759185 | ||
| 1124 | Phosphorylation | LQEKDQKYIFAAVDQ HHHHCCCEEEEECCC | - | ||
| 1137 | Phosphorylation | DQKPSVISLQKLIAR CCCCCHHHHHHHHHH | 24719451 | ||
| 1189 | Phosphorylation | RIQQAVESCPEEKGG HHHHHHHHCCHHHCC | 30631047 | ||
| 1194 | Ubiquitination | VESCPEEKGGRTSES HHHCCHHHCCCCCCC | 29967540 | ||
| 1307 | Phosphorylation | CEDSCGDSVLADTLS HHCCCCCCHHHHHHC | - | ||
| 1312 | Phosphorylation | GDSVLADTLSSHDVP CCCHHHHHHCCCCCC | - | ||
| 1314 | Phosphorylation | SVLADTLSSHDVPGS CHHHHHHCCCCCCCC | - | ||
| 1315 | Phosphorylation | VLADTLSSHDVPGSP HHHHHHCCCCCCCCC | - | ||
| 1321 | Phosphorylation | SSHDVPGSPTASLVT CCCCCCCCCCEEEEC | 28857561 | ||
| 1321 (in isoform 6) | Phosphorylation | - | 27251275 | ||
| 1323 | Phosphorylation | HDVPGSPTASLVTGG CCCCCCCCEEEECCC | 28857561 | ||
| 1427 | Phosphorylation | GPLQDQKSRDADRQH CCCCCCCCCHHHHHH | 28857561 | ||
| 1481 | Phosphorylation | ERERECQSQEELLLR HHHHHHHCHHHHHHH | 21712546 | ||
| 1538 | Phosphorylation | WKHGRQRSLPAVLLP HHCCCCCCCCEEEEC | 22617229 | ||
| 1538 (in isoform 6) | Phosphorylation | - | 27251275 | ||
| 1556 | Phosphorylation | EVMELNRSESLCHEN HHHCCCCCCCCCCCC | 28348404 | ||
| 1558 | Phosphorylation | MELNRSESLCHENSF HCCCCCCCCCCCCCH | 28348404 | ||
| 1564 | Phosphorylation | ESLCHENSFFINEAL CCCCCCCCHHHHHHH | 28348404 | ||
| 1592 | Phosphorylation | SVIHQDATYPTTQSH HHHCCCCCCCCCCCH | 27251275 | ||
| 1592 (in isoform 6) | Phosphorylation | - | 27251275 | ||
| 1595 | Phosphorylation | HQDATYPTTQSHSDL CCCCCCCCCCCHHHH | 27732954 | ||
| 1596 | Phosphorylation | QDATYPTTQSHSDLV CCCCCCCCCCHHHHC | 27732954 | ||
| 1598 | Phosphorylation | ATYPTTQSHSDLVRT CCCCCCCCHHHHCCC | 28857561 | ||
| 1600 | Phosphorylation | YPTTQSHSDLVRTSE CCCCCCHHHHCCCCC | 29496963 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ARG28_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ARG28_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ARG28_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ARG28_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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