TA2R_HUMAN - dbPTM
TA2R_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TA2R_HUMAN
UniProt AC P21731
Protein Name Thromboxane A2 receptor
Gene Name TBXA2R
Organism Homo sapiens (Human).
Sequence Length 343
Subcellular Localization Cell membrane
Multi-pass membrane protein.
Protein Description Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase..
Protein Sequence MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4N-linked_Glycosylation----MWPNGSSLGPC
----CCCCCCCCCCC		47.68UniProtKB CARBOHYD
6Phosphorylation--MWPNGSSLGPCFR
--CCCCCCCCCCCCC		29.0927732954
7Phosphorylation-MWPNGSSLGPCFRP
-CCCCCCCCCCCCCC		38.4527732954
16N-linked_GlycosylationGPCFRPTNITLEERR
CCCCCCCCCCHHHHH		28.12UniProtKB CARBOHYD
118PhosphorylationVMIFFGLSPLLLGAA
HHHHHCCHHHHHHHH		17.55-
128PhosphorylationLLGAAMASERYLGIT
HHHHHHHHHHHCCCC		14.99-
145PhosphorylationFSRPAVASQRRAWAT
CCCHHHHCHHHHHHH		20.02-
239PhosphorylationAQQRPRDSEVEMMAQ
HHHCCCCHHHHHHHH		44.83-
268PhosphorylationLLVFIAQTVLRNPPA
HHHHHHHHHHHCCCC		16.7024719451
324PhosphorylationRRLQPRLSTRPRSLS
HHHCHHHCCCCCCCC		24.5324275569
329PhosphorylationRLSTRPRSLSLQPQL
HHCCCCCCCCCCCHH		25.6230266825
330 (in isoform 2)Phosphorylation-6.6412147288
331PhosphorylationSTRPRSLSLQPQLTQ
CCCCCCCCCCCHHHH		26.6322167270
332 (in isoform 2)Phosphorylation-11.90-
337PhosphorylationLSLQPQLTQRSGLQ-
CCCCCHHHHCCCCC-		19.3830266825
347S-palmitoylationSGLQ-----------
CCCC-----------		17229546
357 (in isoform 2)Phosphorylation--
373S-palmitoylation-------------------------------------
-------------------------------------		17229546
377S-palmitoylation-----------------------------------------
-----------------------------------------		17229546
399 (in isoform 2)Phosphorylation-15100160
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
145SPhosphorylationKinasePKCAP17252
PSP
239SPhosphorylationKinaseGRK2P25098
PSP
239SPhosphorylationKinaseGRK3P35626
PSP
324SPhosphorylationKinasePKACAP17612
PSP
324SPhosphorylationKinasePKC-FAMILY-GPS
324SPhosphorylationKinasePRKCAP17252
GPS
329SPhosphorylationKinasePKC-FAMILY-GPS
329SPhosphorylationKinasePRKACAP17612
GPS
329SPhosphorylationKinasePKA-FAMILY-GPS
329SPhosphorylationKinasePRKCAP17252
GPS
330SPhosphorylationKinasePRKACAP17612
GPS
330SPhosphorylationKinasePRKG1Q13976
GPS
330SPhosphorylationKinasePKA-FAMILY-GPS
331SPhosphorylationKinasePKACAP17612
PSP
331SPhosphorylationKinasePKG-FAMILY-GPS
331SPhosphorylationKinasePKC-FAMILY-GPS
331SPhosphorylationKinasePKA-FAMILY-GPS
331SPhosphorylationKinasePRKCAP17252
GPS
331SPhosphorylationKinasePKG1Q13976
PSP
332TPhosphorylationKinasePRKG1Q13976
GPS
332TPhosphorylationKinasePRKACAP17612
GPS
337TPhosphorylationKinasePRKCAP17252
GPS
357SPhosphorylationKinaseGRK2P25098
PSP
357SPhosphorylationKinaseGRK3P35626
PSP
399TPhosphorylationKinasePRKCAP17252
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TA2R_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TA2R_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PSA7_HUMANPSMA7physical
17499743
PSME3_HUMANPSME3physical
17499743
GNAS3_HUMANGNASphysical
15782186
GNAS2_HUMANGNASphysical
15782186
ALEX_HUMANGNASphysical
15782186
GNAS1_HUMANGNASphysical
15782186
GNA13_HUMANGNA13physical
15782186
GNAQ_HUMANGNAQphysical
15782186
GNAI2_HUMANGNAI2physical
15782186
GBB1_HUMANGNB1physical
15782186
GBG2_HUMANGNG2physical
15782186
FTM_HUMANRPGRIP1Lphysical
19464661
PRDX4_HUMANPRDX4physical
17644091
NDKB_HUMANNME2physical
14976202
WDR36_HUMANWDR36physical
21940795
GNAQ_HUMANGNAQphysical
21940795
GNA11_HUMANGNA11physical
12193606
RACK1_HUMANGNB2L1physical
18088317
TA2R_HUMANTBXA2Rphysical
17202780
PSME3_HUMANPSME3physical
17202780
PSA7_HUMANPSMA7physical
17202780
TA2R_HUMANTBXA2Rphysical
15893915
GASP1_HUMANGPRASP1physical
15086532
PI2R_HUMANPTGIRphysical
15471868
TA2R_HUMANTBXA2Rphysical
21213014
TA2R_HUMANTBXA2Rphysical
16565578
TA2R_HUMANTBXA2Rphysical
23493750
PI2R_HUMANPTGIRphysical
23493750
GNA11_HUMANGNA11physical
23493750
TA2R_HUMANTBXA2Rphysical
20522800
AAMP_HUMANAAMPphysical
21172430
TA2R_HUMANTBXA2Rphysical
17134677
1433Z_HUMANYWHAZphysical
16413928
RAF1_HUMANRAF1physical
16413928
GHRL_HUMANGHRLphysical
18573679
KCMA1_HUMANKCNMA1physical
20959415
GNA13_HUMANGNA13physical
10488151
GNAQ_HUMANGNAQphysical
20590159
RB11A_HUMANRAB11Aphysical
20395296
KCMA1_HUMANKCNMA1physical
23255603
KCMB1_HUMANKCNMB1physical
23255603
SIVA_HUMANSIVA1physical
22343716
RB11A_HUMANRAB11Aphysical
16126723
PKN1_HUMANPKN1physical
21357687
RHOA_HUMANRHOAphysical
21357687
GNA13_HUMANGNA13physical
12399457
GBB1_HUMANGNB1physical
12399457
GNAQ_HUMANGNAQphysical
12399457
GNAQ_HUMANGNAQphysical
15134434
RB11A_HUMANRAB11Aphysical
15134434
ARRB2_HUMANARRB2physical
16956790
GNAQ_HUMANGNAQphysical
12726995
GNAQ_HUMANGNAQphysical
23962128
Drug and Disease Associations
Kegg Disease
H01235 Bleeding disorder platelet-type
OMIM Disease
614009Bleeding disorder, platelet-type 13 (BDPLT13)
Kegg Drug
D01123 Seratrodast (JAN/USAN/INN); Bronica (TN)
D01128 Ramatroban (JAN/INN); Baynas (TN)
D03642 Daltroban (USAN/INN)
D04500 Ifetroban (USAN/INN)
D04501 Ifetroban sodium (USAN)
D05727 Ridogrel (USAN/INN)
D05970 Sulotroban (USAN/INN)
D06280 Vapiprost hydrochloride (JAN/USAN)
D07140 Picotamide (BAN); Plactidil (TN)
D09774 Imitrodast sodium (JAN); RS 5186
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TA2R_HUMAN

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Related Literatures of Post-Translational Modification

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