KCMB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCMB1_HUMAN
• UniProt AC: Q16558
• Protein Name: Calcium-activated potassium channel subunit beta-1
• Gene Name: KCNMB1
• Organism: Homo sapiens (Human).
• Sequence Length: 191
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate..
• Protein Sequence: MVKKLVMAQKRGETRALCLGVTMVVCAVITYYILVTTVLPLYQKSVWTQESKCHLIETNIRDQEELKGKKVPQYPCLWVNVSAAGRWAVLYHTEDTRDQNQQCSYIPGSVDNYQTARADVEKVRAKFQEQQVFYCFSAPRGNETSVLFQRLYGPQALLFSLFWPTFLLTGGLLIIAMVKSNQYLSILAAQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	N-linked_Glycosylation	QYPCLWVNVSAAGRW CCCEEEEECCCCCCE	15.50	UniProtKB CARBOHYD
137	Phosphorylation	QQVFYCFSAPRGNET CEEEEEEECCCCCCC	33.53	24719451
142	N-linked_Glycosylation	CFSAPRGNETSVLFQ EEECCCCCCCHHHHH	51.13	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO32	Q969P5	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCMB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCMB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCMA1_HUMAN	KCNMA1	physical	23255603
TA2R_HUMAN	TBXA2R	physical	23255603

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.