ALEX_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALEX_HUMAN
• UniProt AC: P84996
• Protein Name: Protein ALEX
• Gene Name: GNAS {ECO:0000312|HGNC:HGNC:4392}
• Organism: Homo sapiens (Human).
• Sequence Length: 626
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Cell projection, ruffle. Predominantly associated with cell membrane ruffles..
• Protein Description: May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame..
• Protein Sequence: MMARPVDPQRSPDPTFRSSTRHSGKLEPMEATAHLLRKQCPSRLNSPAWEASGLHWSSLDSPVGSMQALRPSAQHSWSPEPSVVPDQAWEDTALHQKKLCPLSLTSLPREAAVNFSYRSQTLLQEAQVLQGSPELLPRSPKPSGLQRLAPEEATALPLRRLCHLSLMEKDLGTTAHPRGFPELSHKSTAAASSRQSRPRVRSASLPPRTRLPSGSQAPSAAHPKRLSDLLLTSRAAAPGWRSPDPRSRLAAPPLGSTTLPSTWTAPQSRLTARPSRSPEPQIRESEQRDPQLRRKQQRWKEPLMPRREEKYPLRGTDPLPPGQPQRIPLPGQPLQPQPILTPGQPQKIPTPGQHQPILTPGHSQPIPTPGQPLPPQPIPTPGRPLTPQPIPTPGRPLTPQPIQMPGRPLRLPPPLRLLRPGQPMSPQLRQTQGLPLPQPLLPPGQPKSAGRPLQPLPPGPDARSISDPPAPRSRLPIRLLRGLLARLPGGASPRAAAAAACTTMKGWPAATMTPAETSPTMGPPDASAGFSIGEIAAAESPSATYSATFSCKPSGAASVDLRVPSPKPRALSRSRRYPWRRSADRCAKKPWRSGPRSAQRRNAVSSSTNNSRTKRWATCVRTACCF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	LLRKQCPSRLNSPAW HHHHHCHHHCCCHHH	57.96	22210691
58	Phosphorylation	ASGLHWSSLDSPVGS HCCCCHHHCCCCCCC	30.88	22210691
65	Phosphorylation	SLDSPVGSMQALRPS HCCCCCCCHHHHCCC	14.14	22210691
154	Phosphorylation	RLAPEEATALPLRRL HCCHHHHHHHHHHHH	31.82	24260401
173	Phosphorylation	LMEKDLGTTAHPRGF HHHHCCCCCCCCCCC	28.27	-
174	Phosphorylation	MEKDLGTTAHPRGFP HHHCCCCCCCCCCCC	22.59	24719451
202	Phosphorylation	QSRPRVRSASLPPRT CCCCCCCCCCCCCCC	21.25	28857561
204	Phosphorylation	RPRVRSASLPPRTRL CCCCCCCCCCCCCCC	42.53	28634120
209	Phosphorylation	SASLPPRTRLPSGSQ CCCCCCCCCCCCCCC	42.19	-
215	Phosphorylation	RTRLPSGSQAPSAAH CCCCCCCCCCCCCCC	27.75	-
227	Phosphorylation	AAHPKRLSDLLLTSR CCCHHHHHHHHHHCC	30.19	24719451
232	Phosphorylation	RLSDLLLTSRAAAPG HHHHHHHHCCCCCCC	19.01	-
233	Phosphorylation	LSDLLLTSRAAAPGW HHHHHHHCCCCCCCC	21.64	-
277	Phosphorylation	LTARPSRSPEPQIRE HCCCCCCCCCCCCCH	37.64	28842319
425	Phosphorylation	LRPGQPMSPQLRQTQ CCCCCCCCHHHHCCC	19.04	28842319
431	Phosphorylation	MSPQLRQTQGLPLPQ CCHHHHCCCCCCCCC	20.40	-
448	Phosphorylation	LPPGQPKSAGRPLQP CCCCCCCCCCCCCCC	42.51	-
464	Phosphorylation	PPGPDARSISDPPAP CCCCCCCCCCCCCCC	28.32	30243723
466	Phosphorylation	GPDARSISDPPAPRS CCCCCCCCCCCCCHH	45.36	30243723
492	Phosphorylation	ARLPGGASPRAAAAA HHCCCCCCHHHHHHH	20.42	27251275
565	Phosphorylation	SVDLRVPSPKPRALS EEEEECCCCCCCHHH	42.57	24719451
593	Phosphorylation	CAKKPWRSGPRSAQR HHCCCCCCCCCHHHH	49.64	-
605	Phosphorylation	AQRRNAVSSSTNNSR HHHHHHCCCCCCCHH	19.03	29083192
606	Phosphorylation	QRRNAVSSSTNNSRT HHHHHCCCCCCCHHH	34.28	29083192
607	Phosphorylation	RRNAVSSSTNNSRTK HHHHCCCCCCCHHHH	27.87	29083192
608	Phosphorylation	RNAVSSSTNNSRTKR HHHCCCCCCCHHHHH	40.13	29083192
611	Phosphorylation	VSSSTNNSRTKRWAT CCCCCCCHHHHHHHH	43.31	23403867
613	Phosphorylation	SSTNNSRTKRWATCV CCCCCHHHHHHHHHH	25.45	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALEX_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ALEX_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALEX_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FSCN1_HUMAN	FSCN1	physical	17353931
PUR6_HUMAN	PAICS	physical	17353931
RUVB1_HUMAN	RUVBL1	physical	17353931
GLYM_HUMAN	SHMT2	physical	17353931
ADCY6_HUMAN	ADCY6	genetic	9228084
GNAS3_HUMAN	GNAS	physical	7797570
GNAS2_HUMAN	GNAS	physical	7797570
ALEX_HUMAN	GNAS	physical	7797570
GNAS1_HUMAN	GNAS	physical	7797570
NUCB1_HUMAN	NUCB1	physical	21988832
NUCB2_HUMAN	NUCB2	physical	21988832
1A02_HUMAN	HLA-A	physical	9914489
1A03_HUMAN	HLA-A	physical	9914489
1A01_HUMAN	HLA-A	physical	9914489
1A26_HUMAN	HLA-A	physical	9914489
AXIN1_HUMAN	AXIN1	physical	16293724
PANX1_HUMAN	PANX1	physical	16293724
GNAL_HUMAN	GNAL	physical	26186194
GBG4_HUMAN	GNG4	physical	26186194
TROP_HUMAN	TRO	physical	26186194
MAGD2_HUMAN	MAGED2	physical	26186194
GBB1_HUMAN	GNB1	physical	26186194
GBB2_HUMAN	GNB2	physical	26186194
GBB4_HUMAN	GNB4	physical	26186194
C1QBP_HUMAN	C1QBP	physical	26186194
MAP2_HUMAN	METAP2	physical	26186194
CPT2_HUMAN	CPT2	physical	26186194
YBEY_HUMAN	YBEY	physical	26186194
GBG10_HUMAN	GNG10	physical	26186194
OCAD1_HUMAN	OCIAD1	physical	26186194
GNA12_HUMAN	GNA12	physical	26186194
ARMX3_HUMAN	ARMCX3	physical	26186194
GBG5_HUMAN	GNG5	physical	26186194
IF4H_HUMAN	EIF4H	physical	26344197
EMAL2_HUMAN	EML2	physical	26344197
GIPC1_HUMAN	GIPC1	physical	26344197
PUR4_HUMAN	PFAS	physical	26344197
RIC8B_HUMAN	RIC8B	physical	12652642
ADCY2_HUMAN	ADCY2	physical	25241761
GPA1_YEAST	GPA1	genetic	8943324
GBB_YEAST	STE4	genetic	8943324
GNAL_HUMAN	GNAL	physical	28514442
TROP_HUMAN	TRO	physical	28514442
OCAD1_HUMAN	OCIAD1	physical	28514442
MAGD2_HUMAN	MAGED2	physical	28514442
GBB4_HUMAN	GNB4	physical	28514442
CPT2_HUMAN	CPT2	physical	28514442
GBG5_HUMAN	GNG5	physical	28514442
MAP2_HUMAN	METAP2	physical	28514442
GNA12_HUMAN	GNA12	physical	28514442
C1QBP_HUMAN	C1QBP	physical	28514442
GBB1_HUMAN	GNB1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.