ADCY2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADCY2_HUMAN
• UniProt AC: Q08462
• Protein Name: Adenylate cyclase type 2
• Gene Name: ADCY2
• Organism: Homo sapiens (Human).
• Sequence Length: 1091
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasm .
• Protein Description: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. [PubMed: 15385642 Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity]
• Protein Sequence: MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNVAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21 (in isoform 2)	Phosphorylation	-	47.89	25690035
22 (in isoform 2)	Phosphorylation	-	26.71	25690035
282	Phosphorylation	TNNFHNLYVKRHTNV CCCCCCEEEECCCCE	14.83	7600537
376	Phosphorylation	IKKVRDATGVDINMR HHHHHHCCCCCCCEE	41.86	28787133
452	Phosphorylation	DGDIRDPYLKQHLVK CCCCCCHHHHHHHEE	30.71	24927040
472	Phosphorylation	NPKGERRSPQHLFRP CCCCCCCCCCCCCCC	34.82	20363803
491	Phosphorylation	DGAKMRASVRMTRYL CHHHHHHHHHHHHHH	10.41	-
539	Phosphorylation	QHNFQNRTLRTKSQK CCCCCCCCCCCHHHH	28.30	26437602
542	Phosphorylation	FQNRTLRTKSQKKRF CCCCCCCCHHHHHHH	37.85	23312004
544	Phosphorylation	NRTLRTKSQKKRFEE CCCCCCHHHHHHHHH	46.77	23312004
584	Phosphorylation	QRISLLFYNKVLEKE HHHHHHHHHHHHHHH	17.65	7453131
659	Phosphorylation	LQCSKKASPLLMWLL HHCCHHHCHHHHHHH	25.59	23532336
713	N-linked_Glycosylation	ETIPPTANTTNTSFS CCCCCCCCCCCCCCC	50.33	UniProtKB CARBOHYD
716	N-linked_Glycosylation	PPTANTTNTSFSASN CCCCCCCCCCCCCCC	31.52	UniProtKB CARBOHYD
757	Ubiquitination	SCSVFLRVNYELKML HHHHHHHCCHHHHHH	11.00	-
826	Phosphorylation	VLGRQNEYYCRLDFL HHCCCCCCCHHHHHH	18.53	24043423
827	Phosphorylation	LGRQNEYYCRLDFLW HCCCCCCCHHHHHHH	2.49	24043423
928	Phosphorylation	ADFDDLLSKPKFSGV HCHHHHHCCCCCCCC	54.96	24719451
933	Phosphorylation	LLSKPKFSGVEKIKT HHCCCCCCCCCCCEE	48.32	24719451
937	Ubiquitination	PKFSGVEKIKTIGST CCCCCCCCCEECCCH	47.28	-
1015	Ubiquitination	AGVIGAQKPQYDIWG EEEECCCCCCCCCCC	33.29	-
1029	Phosphorylation	GNTVNVASRMDSTGV CCEEEHHHHCCCCCC	24.69	-
1083	Phosphorylation	VNTEMSRSLSQSNVA ECHHHHHHHHHHCCC	25.68	26437602
1085	Phosphorylation	TEMSRSLSQSNVAS- HHHHHHHHHHCCCC-	32.58	26437602
1087	Phosphorylation	MSRSLSQSNVAS--- HHHHHHHHCCCC---	29.87	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
491	S	Phosphorylation	Kinase	PKC	-	Uniprot
544	S	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADCY2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADCY2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ADCY5_HUMAN	ADCY5	physical	9268375

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D01697: Colforsin daropate hydrochloride (JAN); Nkh 477; Adehl (TN)
• DrugBank
• There are no disease associations of PTM sites.