ADCY5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ADCY5_HUMAN
• UniProt AC: O95622
• Protein Name: Adenylate cyclase type 5
• Gene Name: ADCY5
• Organism: Homo sapiens (Human).
• Sequence Length: 1261
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein. Cell projection, cilium .
• Protein Description: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. [PubMed: 15385642]
• Protein Sequence: MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSGSKSVSPPGYA --CCCCCCCCCCCCC	29.53	72838287
8	Phosphorylation	MSGSKSVSPPGYAAQ CCCCCCCCCCCCCCC	32.25	24076635
23	Methylation	KTAAPAPRGGPEHRS CCCCCCCCCCHHHHH	65.88	-
53	Phosphorylation	PGGSARGSTKKPGGA CCCCCCCCCCCCCCC	31.34	28348404
62	Phosphorylation	KKPGGAVTPQQQQRL CCCCCCCCHHHHHHH	18.17	54886037
96	Phosphorylation	LAGGFGFSFRSKSAW CCCCCCEEEECCHHH	21.82	24719451
155	Phosphorylation	GTEVRPRSVEVGLEE CCEECCCCEECCCHH	25.88	25849741
230	Phosphorylation	SDKLERLYQRYFFRL HHHHHHHHHHHHHHC	9.36	27251275
233	Phosphorylation	LERLYQRYFFRLNQS HHHHHHHHHHHCCHH	7.49	27251275
368	Phosphorylation	HLAIALRTNAQDQFL HHHHHHHCCCCHHHH	35.44	19664994
567	Phosphorylation	NMRVGIHSGRVHCGV CEEEEECCCCEEEEE	26.78	-
664	Phosphorylation	AKMNRQRTNSIGHNP HHHHHHHCCCCCCCC	25.61	28857561
666	Phosphorylation	MNRQRTNSIGHNPPH HHHHHCCCCCCCCCC	29.36	26657352
728	Phosphorylation	GRAIDARSIDRLRSE HHHHCHHHHHHHHHH	30.48	23532336
754	Phosphorylation	PDLEKKYSKQVDDRF CCHHHHHHHHCHHHH	26.03	-
843	Ubiquitination	LVGVFTITLVFLAAF HHHHHHHHHHHHHHH	17.51	21890473
870	N-linked_Glycosylation	GCLAQEHNISASQVN HHHHHHCCCCHHHCH	29.20	UniProtKB CARBOHYD
887	N-linked_Glycosylation	HVAESAVNYSLGDEQ HHHHHHHCCCCCCCC	22.01	UniProtKB CARBOHYD
1011	Phosphorylation	HAQQVESTARLDFLW HHHHHHHHHHHHHHH	11.42	-
1129	Phosphorylation	IKTIGSTYMAASGLN HHCCCHHHHHCCCCC	6.10	30576142
1138	Phosphorylation	AASGLNDSTYDKVGK HCCCCCCHHCCCCCH	28.00	30576142
1146	Phosphorylation	TYDKVGKTHIKALAD HCCCCCHHHHHHHHH	23.93	30576142
1164	Phosphorylation	KLMDQMKYINEHSFN HHHHHHHHHHHHCCC	12.02	46159635
1169	Phosphorylation	MKYINEHSFNNFQMK HHHHHHHCCCCCCCE	24.40	46159611
1193	Ubiquitination	AGVIGARKPQYDIWG HHHHCCCCCCCCCCC	35.62	21890473
1207	Phosphorylation	GNTVNVASRMDSTGV CCEEEHHHHCCCCCC	24.69	46159617
1252	Phosphorylation	GKGEMMTYFLNGGPP CCCEEEEEECCCCCC	6.54	7066027

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ADCY5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ADCY5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ADCY5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGS2_HUMAN	RGS2	physical	12604604
ADCY5_HUMAN	ADCY5	physical	9275169
GBB2_MOUSE	Gnb2	physical	17110384
GBB1_MOUSE	Gnb1	physical	17110384
RANB9_MOUSE	Ranbp9	physical	17110384
BABA2_MOUSE	Bre	physical	17110384
SNAPN_MOUSE	Snapin	physical	17110384
COX3_MOUSE	COX3	physical	17110384
TSN7_MOUSE	Tspan7	physical	17110384
TUB_MOUSE	Tub	physical	17110384

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 606703: Dyskinesia, familial, with facial myokymia (FDFM)
• Kegg Drug
• D01697: Colforsin daropate hydrochloride (JAN); Nkh 477; Adehl (TN)
• DrugBank
• There are no disease associations of PTM sites.