dbPTM

GBB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GBB2_MOUSE
UniProt AC	P62880
Protein Name	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Gene Name	Gnb2
Organism	Mus musculus (Mouse).
Sequence Length	340
Subcellular Localization	Cytoplasm, perinuclear region.
Protein Description	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction..
Protein Sequence	MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSELEQLRQ ------CHHHHHHHH	51.38	26824392
2	Acetylation	------MSELEQLRQ ------CHHHHHHHH	51.38	-
23	Ubiquitination	NQIRDARKACGDSTL HHHHHHHHHHCCCHH	50.15	-
25	S-nitrosocysteine	IRDARKACGDSTLTQ HHHHHHHHCCCHHHH	7.54	-
25	S-palmitoylation	IRDARKACGDSTLTQ HHHHHHHHCCCHHHH	7.54	28526873
25	S-nitrosylation	IRDARKACGDSTLTQ HHHHHHHHCCCHHHH	7.54	24895380
25	Glutathionylation	IRDARKACGDSTLTQ HHHHHHHHCCCHHHH	7.54	24333276
28	Phosphorylation	ARKACGDSTLTQITA HHHHHCCCHHHHHHC	15.59	23984901
29	Phosphorylation	RKACGDSTLTQITAG HHHHCCCHHHHHHCC	38.27	23984901
31	Phosphorylation	ACGDSTLTQITAGLD HHCCCHHHHHHCCCC	20.29	23984901
34	Phosphorylation	DSTLTQITAGLDPVG CCHHHHHHCCCCCCC	12.59	23984901
50	Phosphorylation	IQMRTRRTLRGHLAK CHHHCHHHHHHHHHH	19.95	25521595
74	Phosphorylation	SRLLVSASQDGKLII CEEEEEECCCCCEEE	22.69	27841257
87	Phosphorylation	IIWDSYTTNKVHAIP EEEECCCCCEEEEEE	25.47	29899451
89	Ubiquitination	WDSYTTNKVHAIPLR EECCCCCEEEEEECC	33.05	-
128	Phosphorylation	CSIYSLKTREGNVRV CEEEEEECCCCCEEE	38.97	29899451
136	Phosphorylation	REGNVRVSRELPGHT CCCCEEEEEECCCCC	14.96	29472430
148	Glutathionylation	GHTGYLSCCRFLDDN CCCCEEEEEEEECCC	1.46	24333276
148	S-nitrosylation	GHTGYLSCCRFLDDN CCCCEEEEEEEECCC	1.46	22588120
149	S-nitrosocysteine	HTGYLSCCRFLDDNQ CCCEEEEEEEECCCC	2.87	-
149	S-nitrosylation	HTGYLSCCRFLDDNQ CCCEEEEEEEECCCC	2.87	22588120
204	Glutathionylation	RTFVSGACDASIKLW CCCCCCCCCCEEEEH	5.25	24333276
204	S-nitrosylation	RTFVSGACDASIKLW CCCCCCCCCCEEEEH	5.25	24895380
204	S-palmitoylation	RTFVSGACDASIKLW CCCCCCCCCCEEEEH	5.25	28526873
209	Ubiquitination	GACDASIKLWDVRDS CCCCCEEEEHHHCHH	40.82	-
216	Phosphorylation	KLWDVRDSMCRQTFI EEHHHCHHHHCCCCC	14.82	22324799
239	Phosphorylation	VAFFPNGYAFTTGSD EEECCCCEEEECCCC	12.75	18034455
250	S-nitrosylation	TGSDDATCRLFDLRA CCCCCCEEEEEECCC	3.69	24895380
250	S-palmitoylation	TGSDDATCRLFDLRA CCCCCCEEEEEECCC	3.69	28680068
294	Glutathionylation	AGYDDFNCNIWDAMK EEECCCCCCHHHHCC	3.84	24333276
301	Ubiquitination	CNIWDAMKGDRAGVL CCHHHHCCCCCCEEE	60.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GBB2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GBB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GBB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GBB2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GBB2_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-239, AND MASSSPECTROMETRY.	18034455 [Abstract]