GBB1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBB1_MOUSE
• UniProt AC: P62874
• Protein Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
• Gene Name: Gnb1
• Organism: Mus musculus (Mouse).
• Sequence Length: 340
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)..
• Protein Sequence: MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSELDQLRQ ------CCHHHHHHH	47.03	30352176
2	Acetylation	------MSELDQLRQ ------CCHHHHHHH	47.03	-
15	Ubiquitination	RQEAEQLKNQIRDAR HHHHHHHHHHHHHHH	46.64	22790023
23	Ubiquitination	NQIRDARKACADATL HHHHHHHHHHHHCHH	49.92	22790023
25	S-palmitoylation	IRDARKACADATLSQ HHHHHHHHHHCHHHH	3.85	28526873
25	S-nitrosylation	IRDARKACADATLSQ HHHHHHHHHHCHHHH	3.85	24895380
25	Glutathionylation	IRDARKACADATLSQ HHHHHHHHHHCHHHH	3.85	24333276
25	S-nitrosocysteine	IRDARKACADATLSQ HHHHHHHHHHCHHHH	3.85	-
29	Phosphorylation	RKACADATLSQITNN HHHHHHCHHHHHHHC	27.73	20415495
31	Phosphorylation	ACADATLSQITNNID HHHHCHHHHHHHCCC	18.38	25521595
34	Phosphorylation	DATLSQITNNIDPVG HCHHHHHHHCCCCCC	17.99	20415495
50	Phosphorylation	IQMRTRRTLRGHLAK HHHHCHHHHHHHHHH	19.95	25521595
74	Phosphorylation	SRLLVSASQDGKLII CEEEEEECCCCCEEE	22.69	27841257
87	Phosphorylation	IIWDSYTTNKVHAIP EEEECCCCCEEEEEE	25.47	29899451
89	Ubiquitination	WDSYTTNKVHAIPLR EECCCCCEEEEEECC	33.05	-
111	Phosphorylation	AYAPSGNYVACGGLD EECCCCCEEEECCHH	7.92	-
136	O-linked_Glycosylation	REGNVRVSRELAGHT CCCCEEECHHHCCCC	14.96	59149737
136	Phosphorylation	REGNVRVSRELAGHT CCCCEEECHHHCCCC	14.96	29472430
148	S-nitrosylation	GHTGYLSCCRFLDDN CCCCEEEEEEEECCC	1.46	24895380
149	Glutathionylation	HTGYLSCCRFLDDNQ CCCEEEEEEEECCCC	2.87	24333276
149	S-nitrosylation	HTGYLSCCRFLDDNQ CCCEEEEEEEECCCC	2.87	24895380
204	S-nitrosocysteine	RLFVSGACDASAKLW EEEEECCCCCCHHHH	5.25	-
204	S-nitrosylation	RLFVSGACDASAKLW EEEEECCCCCCHHHH	5.25	24895380
209	Ubiquitination	GACDASAKLWDVREG CCCCCCHHHHHHHCC	47.84	-
266	Phosphorylation	QELMTYSHDNIICGI CCCEEECCCCEEEEE	23.02	-
294	Glutathionylation	AGYDDFNCNVWDALK EEECCCCCCHHHHHH	4.36	24333276
294	S-nitrosylation	AGYDDFNCNVWDALK EEECCCCCCHHHHHH	4.36	24895380
301	Ubiquitination	CNVWDALKADRAGVL CCHHHHHHHHCCCEE	50.38	-
317	S-nitrosocysteine	GHDNRVSCLGVTDDG CCCCCCCEEEECCCC	3.33	-
317	Glutathionylation	GHDNRVSCLGVTDDG CCCCCCCEEEECCCC	3.33	24333276
317	S-nitrosylation	GHDNRVSCLGVTDDG CCCCCCCEEEECCCC	3.33	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBB1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
266	H	Phosphorylation	Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBB1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RACK1_MOUSE	Gnb2l1	physical	12359736
DC1I1_MOUSE	Dync1i1	physical	12359736
GBG2_MOUSE	Gng2	physical	8550614
GNAO_MOUSE	Gnao1	physical	8550614
TCPZ_HUMAN	CCT6A	physical	26496610
CH60_HUMAN	HSPD1	physical	26496610
PHLP_HUMAN	PDCL	physical	26496610
PFD1_HUMAN	PFDN1	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
GBG12_HUMAN	GNG12	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.