DC1I1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DC1I1_MOUSE
• UniProt AC: O88485
• Protein Name: Cytoplasmic dynein 1 intermediate chain 1
• Gene Name: Dync1i1
• Organism: Mus musculus (Mouse).
• Sequence Length: 628
• Subcellular Localization: Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
• Protein Description: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores..
• Protein Sequence: MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVPTPMSPSSKSVSTPSDAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVEPKIGHDSELENQEKKQETKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYSNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNSDTEVPTASVAIEGASALNRVRWAQGGKEVAVGDSEGRIWIYDVGELAVPHNDEWTRFARTLVEIRANRADSEEEGAVELAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDKSDLKA ------CCCHHHHHH	54.46	-
2	Phosphorylation	------MSDKSDLKA ------CCCHHHHHH	54.46	29176673
50	Phosphorylation	KEPVQDDSDLDRKRR HCCCCCCHHHHHHHH	48.65	25521595
59	Phosphorylation	LDRKRRETEALLQSI HHHHHHHHHHHHHHC	25.42	24925903
65	Phosphorylation	ETEALLQSIGISPEP HHHHHHHHCCCCCCC	23.81	24925903
69	Phosphorylation	LLQSIGISPEPPLVP HHHHCCCCCCCCCCC	20.28	25521595
77	Phosphorylation	PEPPLVPTPMSPSSK CCCCCCCCCCCCCCC	24.93	29899451
80	Phosphorylation	PLVPTPMSPSSKSVS CCCCCCCCCCCCCCC	23.88	24925903
82	Phosphorylation	VPTPMSPSSKSVSTP CCCCCCCCCCCCCCC	42.99	29899451
83	Phosphorylation	PTPMSPSSKSVSTPS CCCCCCCCCCCCCCC	32.13	29899451
87	Phosphorylation	SPSSKSVSTPSDAGS CCCCCCCCCCCCCCC	41.51	22807455
88	Phosphorylation	PSSKSVSTPSDAGSQ CCCCCCCCCCCCCCC	25.34	22807455
90	Phosphorylation	SKSVSTPSDAGSQDS CCCCCCCCCCCCCCC	39.93	22807455
94 (in isoform 2)	Phosphorylation	-	32.32	25521595
94	Phosphorylation	STPSDAGSQDSGDLG CCCCCCCCCCCCCCC	32.32	19060867
97	Phosphorylation	SDAGSQDSGDLGPLT CCCCCCCCCCCCCCE	26.94	19060867
148	Phosphorylation	FLPREVVSYSKETQT ECCHHHHCCCCCCCC	28.94	16452087
150	Phosphorylation	PREVVSYSKETQTPL CHHHHCCCCCCCCCC	19.26	16452087
153	Phosphorylation	VVSYSKETQTPLATH HHCCCCCCCCCCCCC	41.29	24925903
155	Phosphorylation	SYSKETQTPLATHQS CCCCCCCCCCCCCCC	27.91	25521595
159	Phosphorylation	ETQTPLATHQSEEDE CCCCCCCCCCCCCCC	28.29	25521595
162	Phosphorylation	TPLATHQSEEDEEDE CCCCCCCCCCCCCCH	35.04	25521595
180	Phosphorylation	EPKIGHDSELENQEK CCCCCCHHHHHHHHH	38.11	25521595
238	Phosphorylation	DSDIFFDYSGRELEE CCCEEECCCCCEEEE	14.10	22871156
239	Phosphorylation	SDIFFDYSGRELEEK CCEEECCCCCEEEEC	32.97	22871156
246	Ubiquitination	SGRELEEKDGDVQAG CCCEEEECCCCCCCC	58.60	-
574	Ubiquitination	VRWAQGGKEVAVGDS CEECCCCCEEEEECC	56.70	-
618	Phosphorylation	IRANRADSEEEGAVE HHHHCCCCCCCCCEE	46.02	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DC1I1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DC1I1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DC1I1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DC1I1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-618, AND MASSSPECTROMETRY.
PubMed: 16452087