GNAO_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNAO_MOUSE
• UniProt AC: P18872
• Protein Name: Guanine nucleotide-binding protein G(o) subunit alpha
• Gene Name: Gnao1
• Organism: Mus musculus (Mouse).
• Sequence Length: 354
• Subcellular Localization: Cell membrane . Membrane ; Lipid-anchor .
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Stimulated by RGS14. The G(o) protein function is not clear..
• Protein Sequence: MGCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKTDSKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAGDYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDAAAYIQTQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGCTLSAEE ------CCCCCCHHH	17.08	-
3	S-palmitoylation	-----MGCTLSAEER -----CCCCCCHHHH	3.14	-
21	Ubiquitination	ERSKAIEKNLKEDGI HHHHHHHHHHHHCCC	62.56	22790023
21 (in isoform 2)	Ubiquitination	-	62.56	22790023
24	Ubiquitination	KAIEKNLKEDGISAA HHHHHHHHHCCCCHH	64.25	22790023
24 (in isoform 2)	Ubiquitination	-	64.25	22790023
29	Phosphorylation	NLKEDGISAAKDVKL HHHHCCCCHHHHHEE	27.92	22324799
32	Ubiquitination	EDGISAAKDVKLLLL HCCCCHHHHHEEEEE	63.87	22790023
32 (in isoform 2)	Ubiquitination	-	63.87	22790023
35 (in isoform 2)	Ubiquitination	-	43.48	22790023
35	Ubiquitination	ISAAKDVKLLLLGAG CCHHHHHEEEEECCC	43.48	22790023
44	Phosphorylation	LLLGAGESGKSTIVK EEECCCCCCCCHHHE	51.07	22817900
46	Ubiquitination	LGAGESGKSTIVKQM ECCCCCCCCHHHEEE	54.42	22790023
46 (in isoform 2)	Ubiquitination	-	54.42	22790023
47	Phosphorylation	GAGESGKSTIVKQMK CCCCCCCCHHHEEEE	27.22	29899451
48	Phosphorylation	AGESGKSTIVKQMKI CCCCCCCHHHEEEEE	33.02	-
51	Ubiquitination	SGKSTIVKQMKIIHE CCCCHHHEEEEEECC	40.60	-
54	Ubiquitination	STIVKQMKIIHEDGF CHHHEEEEEECCCCC	35.69	22790023
54 (in isoform 2)	Ubiquitination	-	35.69	22790023
62	Phosphorylation	IIHEDGFSGEDVKQY EECCCCCCCCHHHHH	46.96	19060867
67 (in isoform 2)	Ubiquitination	-	61.30	22790023
67	Ubiquitination	GFSGEDVKQYKPVVY CCCCCHHHHHCCEEE	61.30	22790023
69	Nitration	SGEDVKQYKPVVYSN CCCHHHHHCCEEEHH	16.13	-
70 (in isoform 2)	Ubiquitination	-	28.92	22790023
70	Ubiquitination	GEDVKQYKPVVYSNT CCHHHHHCCEEEHHH	28.92	22790023
98 (in isoform 2)	Ubiquitination	-	55.87	22790023
98	Ubiquitination	LGVEYGDKERKTDSK HCCCCCCCCCCCCCH	55.87	22790023
101	Ubiquitination	EYGDKERKTDSKMVC CCCCCCCCCCCHHHH	58.75	-
105 (in isoform 2)	Ubiquitination	-	37.86	22790023
105	Ubiquitination	KERKTDSKMVCDVVS CCCCCCCHHHHHHHH	37.86	22790023
108	S-nitrosylation	KTDSKMVCDVVSRME CCCCHHHHHHHHCCC	2.69	24895380
112	Phosphorylation	KMVCDVVSRMEDTEP HHHHHHHHCCCCCCC	26.26	20415495
126	Phosphorylation	PFSAELLSAMMRLWG CCCHHHHHHHHHHHC	27.09	-
135	Phosphorylation	MMRLWGDSGIQECFN HHHHHCCCHHHHHHH	33.58	29899451
140	S-nitrosylation	GDSGIQECFNRSREY CCCHHHHHHHHCCCC	1.78	24895380
154	Ubiquitination	YQLNDSAKYYLDSLD CCCCCHHHHHHHCCC	38.08	22790023
154 (in isoform 2)	Ubiquitination	-	38.08	22790023
155	Phosphorylation	QLNDSAKYYLDSLDR CCCCHHHHHHHCCCC	14.69	20415495
156	Phosphorylation	LNDSAKYYLDSLDRI CCCHHHHHHHCCCCC	11.88	20415495
159	Phosphorylation	SAKYYLDSLDRIGAG HHHHHHHCCCCCCCC	29.58	19060867
181 (in isoform 2)	Ubiquitination	-	36.76	22790023
181	Ubiquitination	DILRTRVKTTGIVET HHHHHHCCCCCEEEE	36.76	22790023
193	Ubiquitination	VETHFTFKNLHFRLF EEEEEEECCEEEEEE	56.39	-
205	Formation of an isopeptide bond	RLFDVGGQRSERKKW EEEECCCCCCCHHHH	39.54	23022564
207	Phosphorylation	FDVGGQRSERKKWIH EECCCCCCCHHHHCH	33.59	25521595
249 (in isoform 2)	Ubiquitination	-	4.95	-
253	Phosphorylation	ESLMLFDSICNNKFF HHHHHHHHHHCCCEE	23.00	22324799
278	Ubiquitination	KKDLFGEKIKKSPLT HHHHCCCHHCCCCCE	61.27	22790023
287	S-palmitoylation	KKSPLTICFPEYPGS CCCCCEEECCCCCCC	3.81	28680068
297	Phosphorylation	EYPGSNTYEDAAAYI CCCCCCCHHHHHHHH	18.96	29899451
311	Ubiquitination	IQTQFESKNRSPNKE HHHHHHHCCCCCCCE	49.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNAO_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNAO_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNAO_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LDHA_MOUSE	Ldha	physical	10196137
GPSM2_MOUSE	Gpsm2	physical	10196137
PCP2_MOUSE	Pcp2	physical	10196137

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.