GPSM2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPSM2_MOUSE
• UniProt AC: Q8VDU0
• Protein Name: G-protein-signaling modulator 2
• Gene Name: Gpsm2
• Organism: Mus musculus (Mouse).
• Sequence Length: 679
• Subcellular Localization: Cytoplasm . Cytoplasm, cell cortex . Cytoplasm, cytoskeleton, spindle pole . Lateral cell membrane . Localizes in the cytoplasm during interphase and at cell cortex during metaphase. Colocalizes with NUMA1 to mitotic spindle poles. Localized at the c
• Protein Description: Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. [PubMed: 21816348 Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity Plays a role in metaphase spindle orientation (By similarity Plays an important role in asymmetric cell divisions]
• Protein Sequence: MEGNLISMREDHSFHVRYRMEASCLELALEGERLCKSGDCRAGVSFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLHDYAKALEYHHHDLTLARTIGDQLGEAKASGNLGNTLKVLGNFDEAIVCCQRHLDISRELNDKVGEARALYNLGNVYHAKGKSFGCPGPQDTGEFPEDVRNALQAAVDLYEENLSLVTALGDRAAQGRAFGNLGNTHYLLGNFRDAVIAHEQRLLIAKEFGDKAAERRAYSNLGNAYIFLGEFETASEYYKKTLLLARQLKDRAVEAQSCYSLGNTYTLLQDYEKAIDYHLKHLAIAQELKDRIGEGRACWSLGNAYTALGNHDQAMHFAEKHLEISREVGDKSGELTARLNLSDLQMVLGLSYSTNNSMMSENIEIDGSLHGAGAKLGRRHSMENLELMKLTPEKVPNWNSEILAKQKPLIAKPSAKLLFVNRLKGKKYKSGSACTKVLQDASNSVDHRAPRSQKKISSDTIGDEGFFDLLRRFQSNRMDDQRCHLQGNCRTTSTAAASATPKLMKAPSVSVVSPNTDEFLDLLASSQSRRLDDQRASFSNLPGLRLTKGNSPSVLERLMTNDKKEPDEDFFDILVKCQGSRLDDQRCAPPSAATKGPTVPDEDFFSLILRSQAKRMDEQRVLLQRDPNRDSEFGLKELLQNNALLEFKHSGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	VRYRMEASCLELALE EEEEHHHHHHHHHHH	13.11	26643407
146	Phosphorylation	VGEARALYNLGNVYH HHHHHHHHHCCCEEE	13.83	-
155	Ubiquitination	LGNVYHAKGKSFGCP CCCEEECCCCCCCCC	54.26	-
401	Phosphorylation	GSLHGAGAKLGRRHS CCCCCHHHCCCCCCC	11.90	19144319
408	Phosphorylation	AKLGRRHSMENLELM HCCCCCCCHHHHHHC	26.44	26824392
418	Phosphorylation	NLELMKLTPEKVPNW HHHHCCCCCCCCCCC	24.71	26643407
441	Phosphorylation	KPLIAKPSAKLLFVN CCCCCCCCCEEEEEE	37.01	29514104
484	Phosphorylation	PRSQKKISSDTIGDE CHHHCCCCCCCCCCC	30.92	-
487	Phosphorylation	QKKISSDTIGDEGFF HCCCCCCCCCCCHHH	28.89	-
525	Phosphorylation	TTSTAAASATPKLMK CCCHHHHHCCCCCCC	28.13	25367039
527	Phosphorylation	STAAASATPKLMKAP CHHHHHCCCCCCCCC	20.61	25367039
535	Phosphorylation	PKLMKAPSVSVVSPN CCCCCCCCEEEECCC	31.70	26643407
537	Phosphorylation	LMKAPSVSVVSPNTD CCCCCCEEEECCCHH	22.57	26643407
540	Phosphorylation	APSVSVVSPNTDEFL CCCEEEECCCHHHHH	15.41	26643407
543	Phosphorylation	VSVVSPNTDEFLDLL EEEECCCHHHHHHHH	40.05	26643407
552	Phosphorylation	EFLDLLASSQSRRLD HHHHHHHHHCCCCHH	28.95	-
553	Phosphorylation	FLDLLASSQSRRLDD HHHHHHHHCCCCHHH	26.94	-
555	Phosphorylation	DLLASSQSRRLDDQR HHHHHHCCCCHHHHH	22.70	-
557	Phosphorylation	LASSQSRRLDDQRAS HHHHCCCCHHHHHHC	47.95	19144319
564	Phosphorylation	RLDDQRASFSNLPGL CHHHHHHCCCCCCCC	31.25	26824392
566	Phosphorylation	DDQRASFSNLPGLRL HHHHHCCCCCCCCCC	34.65	28066266
578	Phosphorylation	LRLTKGNSPSVLERL CCCCCCCCHHHHHHH	27.50	26643407
580	Phosphorylation	LTKGNSPSVLERLMT CCCCCCHHHHHHHHH	38.87	26643407
658	Phosphorylation	QRDPNRDSEFGLKEL HCCCCCCCCCCHHHH	31.43	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
408	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPSM2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPSM2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GPSM2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408 AND SER-564, ANDMASS SPECTROMETRY.
PubMed: 19144319

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408, AND MASSSPECTROMETRY.
PubMed: 19367708