| UniProt ID | TUB_MOUSE | |
|---|---|---|
| UniProt AC | P50586 | |
| Protein Name | Tubby protein | |
| Gene Name | Tub | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 505 | |
| Subcellular Localization |
Cytoplasm. Nucleus. Secreted. Cell membrane Peripheral membrane protein Cytoplasmic side. Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase |
|
| Protein Description | Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity).. | |
| Protein Sequence | MTSKPHSDWIPYSVLDDEGSNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSIASVQLGATRPPAPASAKKSKGAAASGGQGGAPRKEKKGKHKGTSGPATLAEDKSEAQGPVQILTVGQSDHDKDAGETAAGGGAQPSGQDLRATMQRKGISSSMSFDEDEDEDENSSSSSQLNSNTRPSSATSRKSIREAASAPSPAAPEPPVDIEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVCIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 58 | Phosphorylation | NADGRPRSRRARQSE CCCCCCCCHHHHHCH | 28.88 | 29899451 | |
| 159 | Phosphorylation | QILTVGQSDHDKDAG EEEEECCCCCCCCCC | 30.86 | 21454597 | |
| 192 | Phosphorylation | MQRKGISSSMSFDED HHHCCCCCCCCCCCC | 28.30 | 29899451 | |
| 235 | Phosphorylation | REAASAPSPAAPEPP HHHHCCCCCCCCCCC | 27.21 | 29899451 | |
| 385 | Phosphorylation | FKGPRKMSVIVPGMN CCCCCCCEEEECCCC | 16.24 | 21189417 | |
| 464 | Phosphorylation | IHGNDPDYIVMQFGR EECCCCCEEEEECCC | 10.78 | - | |
| 478 | Phosphorylation | RVAEDVFTMDYNYPL CCCCCCCCCCCCCHH | 14.69 | 24068923 | |
| 481 | Phosphorylation | EDVFTMDYNYPLCAL CCCCCCCCCCHHHHH | 13.03 | 24068923 | |
| 483 | Phosphorylation | VFTMDYNYPLCALQA CCCCCCCCHHHHHHH | 7.43 | 24068923 | |
| 496 | Phosphorylation | QAFAIALSSFDSKLA HHHHHHHHHCCHHHC | 21.67 | 24068923 | |
| 497 | Phosphorylation | AFAIALSSFDSKLAC HHHHHHHHCCHHHCC | 33.64 | 24068923 | |
| 500 | Phosphorylation | IALSSFDSKLACE-- HHHHHCCHHHCCC-- | 27.79 | 24068923 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TUB_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TUB_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TUB_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TUB_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
