RGS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGS2_HUMAN
• UniProt AC: P41220
• Protein Name: Regulator of G-protein signaling 2
• Gene Name: RGS2
• Organism: Homo sapiens (Human).
• Sequence Length: 211
• Subcellular Localization: Isoform 1: Cell membrane . Cytoplasm . Nucleus, nucleolus .; Isoform 2: Cell membrane . Cytoplasm . Nucleus, nucleolus .; Isoform 3: Cell membrane . Cytoplasm . Nucleus, nucleolus .; Isoform 4: Cell membrane . Mitochondrion .
• Protein Description: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. [PubMed: 11063746]
• Protein Sequence: MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	KMKRTLLKDWKTRLS HHHHHHHHHHHHHHH	65.73	-
46	Phosphorylation	KDWKTRLSYFLQNSS HHHHHHHHHHHHCCC	15.56	14608379
47	Phosphorylation	DWKTRLSYFLQNSST HHHHHHHHHHHCCCC	16.95	24719451
52	Phosphorylation	LSYFLQNSSTPGKPK HHHHHHCCCCCCCCC	23.72	28555341
53	Phosphorylation	SYFLQNSSTPGKPKT HHHHHCCCCCCCCCC	46.28	24719451
54	Phosphorylation	YFLQNSSTPGKPKTG HHHHCCCCCCCCCCC	35.56	28555341
57	Ubiquitination	QNSSTPGKPKTGKKS HCCCCCCCCCCCCCC	44.54	-
64	Phosphorylation	KPKTGKKSKQQAFIK CCCCCCCCCCEECCC	38.90	14608379
71	Ubiquitination	SKQQAFIKPSPEEAQ CCCEECCCCCHHHHH	32.75	-
106	S-palmitoylation	AFLKSEFCEENIEFW HHHHHHHHHHHHHHH	5.87	16945566
116	S-palmitoylation	NIEFWLACEDFKKTK HHHHHHHCHHHHCCC	4.89	16945566
121	Acetylation	LACEDFKKTKSPQKL HHCHHHHCCCCHHHH	62.27	12654859
123	Acetylation	CEDFKKTKSPQKLSS CHHHHCCCCHHHHHH	69.85	12654869
127	Ubiquitination	KKTKSPQKLSSKARK HCCCCHHHHHHHHHH	54.44	-
134	Ubiquitination	KLSSKARKIYTDFIE HHHHHHHHHHHHHHH	44.94	-
142	Ubiquitination	IYTDFIEKEAPKEIN HHHHHHHHHCCCCCC	55.12	-
146	Ubiquitination	FIEKEAPKEINIDFQ HHHHHCCCCCCCCHH	77.57	-
156	Phosphorylation	NIDFQTKTLIAQNIQ CCCHHHHHHHHHHHH	27.12	28985074
167	Phosphorylation	QNIQEATSGCFTTAQ HHHHHHHCCCCHHHH	40.38	28985074
171	Phosphorylation	EATSGCFTTAQKRVY HHHCCCCHHHHHHHH	25.87	28985074
172	Phosphorylation	ATSGCFTTAQKRVYS HHCCCCHHHHHHHHH	13.57	28985074
175	Ubiquitination	GCFTTAQKRVYSLME CCCHHHHHHHHHHHH	41.17	-
178	Phosphorylation	TTAQKRVYSLMENNS HHHHHHHHHHHHCCC	10.50	30257219
179	Phosphorylation	TAQKRVYSLMENNSY HHHHHHHHHHHCCCC	20.55	-
186	Phosphorylation	SLMENNSYPRFLESE HHHHCCCCCCHHHHH	10.68	30257219
195	Phosphorylation	RFLESEFYQDLCKKP CHHHHHHHHHHHCCC	9.32	27642862
199	S-palmitoylation	SEFYQDLCKKPQITT HHHHHHHHCCCCCCC	7.77	16945566
201	Ubiquitination	FYQDLCKKPQITTEP HHHHHHCCCCCCCCC	40.95	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
46	S	Phosphorylation	Kinase	PRKG1	Q13976	GPS
64	S	Phosphorylation	Kinase	PRKG1	Q13976	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NINL_HUMAN	NINL	physical	16189514
IBTK_HUMAN	IBTK	physical	17353931
EIF3E_HUMAN	EIF3E	physical	17353931
KGP1_HUMAN	PRKG1	physical	14608379
GNA15_HUMAN	GNA15	physical	12885252
GNAQ_HUMAN	GNAQ	physical	12885252
WDR74_HUMAN	WDR74	physical	16169070
LRFN1_HUMAN	LRFN1	physical	16169070
NIPS1_HUMAN	NIPSNAP1	physical	16169070
VPS29_HUMAN	VPS29	physical	16169070
ARFG1_HUMAN	ARFGAP1	physical	16169070
DYL1_HUMAN	DYNLL1	physical	16169070
PRKN_HUMAN	PARK2	physical	16169070
GLU2B_HUMAN	PRKCSH	physical	16169070
DDR1_HUMAN	DDR1	physical	16169070
HSP7C_HUMAN	HSPA8	physical	16169070
GIT1_HUMAN	GIT1	physical	16169070
GNAI3_HUMAN	GNAI3	physical	9079700
GDE1_HUMAN	GDE1	physical	10760272
GNAS3_HUMAN	GNAS	physical	9794454
GNAS2_HUMAN	GNAS	physical	9794454
ALEX_HUMAN	GNAS	physical	9794454
GNAS1_HUMAN	GNAS	physical	9794454
PRKN_HUMAN	PARK2	physical	21900206
WDR74_HUMAN	WDR74	physical	21900206
TSN15_HUMAN	TSPAN15	physical	21900206
GLU2B_HUMAN	PRKCSH	physical	21900206
DYL1_HUMAN	DYNLL1	physical	21900206
CATB_HUMAN	CTSB	physical	21900206
RAB2A_HUMAN	RAB2A	physical	21900206
DNLI1_HUMAN	LIG1	physical	21900206
BBS10_HUMAN	BBS10	physical	21900206
GIT1_HUMAN	GIT1	physical	21900206
CE126_HUMAN	KIAA1377	physical	21900206
DDR1_HUMAN	DDR1	physical	21900206
REEP5_HUMAN	REEP5	physical	21900206
ZYX_HUMAN	ZYX	physical	21900206
COMT_HUMAN	COMT	physical	21900206
NIPS1_HUMAN	NIPSNAP1	physical	21900206
EIF3L_HUMAN	EIF3L	physical	21900206
TZAP_HUMAN	ZBTB48	physical	21900206
IR3IP_HUMAN	IER3IP1	physical	21900206
ZN579_HUMAN	ZNF579	physical	21900206
MON1A_HUMAN	MON1A	physical	21900206
HSP7C_HUMAN	HSPA8	physical	21900206
HAUS5_HUMAN	HAUS5	physical	21900206
DUS21_HUMAN	DUSP21	physical	21900206
PRAF1_HUMAN	RABAC1	physical	21900206
UBC_HUMAN	UBC	physical	21900206
LRFN1_HUMAN	LRFN1	physical	21900206
CHD3_HUMAN	CHD3	physical	21900206
RIN3_HUMAN	RIN3	physical	21900206
XRCC6_HUMAN	XRCC6	physical	21900206
TBB2B_HUMAN	TUBB2B	physical	21900206
DPYL1_HUMAN	CRMP1	physical	21900206
MET18_HUMAN	METTL18	physical	21900206
VPS29_HUMAN	VPS29	physical	21900206
MTUS2_HUMAN	MTUS2	physical	25416956
FBX44_HUMAN	FBXO44	physical	25970626
DDB1_HUMAN	DDB1	physical	25970626
NINL_HUMAN	NINL	physical	28514442
MIPO1_HUMAN	MIPOL1	physical	28514442
PTN13_HUMAN	PTPN13	physical	28514442
STXB4_HUMAN	STXBP4	physical	28514442
MAP2_HUMAN	METAP2	physical	28514442
STRP1_HUMAN	STRIP1	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
STK26_HUMAN	STK26	physical	28514442
ZPI_HUMAN	SERPINA10	physical	28514442
TAF2_HUMAN	TAF2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.